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Obesity and ER Stress

Koo SH

  • KMID: 2270933
  • Korean J Obes.
  • 2011 Jun;20(2):45-50.
Endoplastic reticulum (ER) is one of the cellular organelle found in all eukaryotes. It plays a critical role in the protein folding, lipid and sterol biosynthesis, and the storage of...
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Endoplasmic Reticulum Stress Responses and Apoptosis

Song CH

The endoplasmic reticulum (ER) plays a crucial role in various cellular activities and cell survival. Almost all of the resident proteins usually enter the ER, and are modified with N-linked...
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Endoplasmic Reticulum Stress and the Related Signaling Networks in Severe Asthma

Kim SR, Lee YC

The endoplasmic reticulum (ER) is a specialized organelle that plays a central role in biosynthesis, correct protein folding, and posttranslational modifications of secretory and membrane proteins. Loss of homeostasis in...
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AI, big data, and robots for the evolution of biotechnology

Kim H

Artificial intelligence (AI), big data, and ubiquitous robotic companions —the three most notable technologies of the 4th Industrial Revolution—are receiving renewed attention each day. Technologies that can be experienced in...
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Secondary Amyloidosis in Patient with Spinal Cord Injury: Renal and Thyroid Amyloidosis

Han ST, Kim MS, Yu JM, Yea CJ, Byun JW, Han BG, Choi SO

  • KMID: 2079586
  • Korean J Nephrol.
  • 2006 Jan;25(1):109-113.
Amyloidosis is an acquired or inherited disorder with protein folding and degradation characterizing the deposition of the proteinaceous material in the extracellular matrix of one or several organs. Secondary amyloidosis...
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Implications of aging and the endoplasmic reticulum unfolded protein response on the molecular modality of breast cancer

Minakshi R, Rahman S, Jan AT, Archana A, Kim J

The endoplasmic reticulum (ER) is an important subcellular organelle that is involved in numerous activities required to achieve and maintain functional proteins in addition to its role in the biosynthesis...
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The Expression of Heat Shock Protein 60 kDa in Tissues and Cell Lines of Breast Cancer

You BC, Park SY, Lee YD, Lee JN, Hwang YJ, Park HK

PURPOSE: Breast cancer has been reported as the most common cancer of women in the United States, Western Europe and Korea and about 210,000 and 10,000 women in United States...
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Analysis of structure-function relationship in porcine rotavirus A enterotoxin gene

Saurabh S, Sircar S, Kattoor JJ, Ghosh S, Kobayashi , Banyai K, VinodhKumar OR, De UK, Sahoo NR, Dhama K, Malik YS

Rotavirus (RV)-infected piglets are presumed to be latent sources of heterologous RV infection in humans and other animals. In RVs, non-structural protein 4 (NSP4) is the major virulence factor with...
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Proteomic Signatures in Spermatozoa Reveal the Role of Paternal Factors in Recurrent Pregnancy Loss

Mohanty G, Jena SR, Nayak J, Kar S, Samanta L

PURPOSE: To identify the paternal factors responsible for aberrant embryo development leading to loss of foetus in recurrent pregnancy loss (RPL) through proteomic analysis of ejaculated spermatozoa. MATERIALS AND METHODS: This...
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Gene expression profile analysis of xylitol-sensitive and xylitol-resistant Streptococcus mutans in 0.5% glucose containing TYE media using DNA chip

Im SU, Ahn SH, Park DO, Choi YH, Song KB

  • KMID: 2321390
  • J Korean Acad Oral Health.
  • 2012 Dec;36(4):251-265.
OBJECTIVES: Streptococcus mutans (S. mutans) is the major causative bacteria in dental caries. Xylitol is an effective anticarious natural sugar substitute by inhibiting the virulence of S. mutans. However, long-term...
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Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes

Ly LD, Xu S, Choi SK, Ha CM, Thoudam T, Cha SK, Wiederkehr A, Wollheim C, Lee IK, Park KS

Free fatty acids (FFAs) are important substrates for mitochondrial oxidative metabolism and ATP synthesis but also cause serious stress to various tissues, contributing to the development of metabolic diseases. CD36...
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Role of Endoplasmic Reticulum Stress in Rheumatoid Arthritis Pathogenesis

Park YJ, Yoo SA, Kim WU

Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by abnormal proliferation of synoviocytes, leukocyte infiltration, and angiogenesis. The endoplasmic reticulum (ER) is the site of biosynthesis for all secreted...
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Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells

Cho YM, Jang YS, Jang YM, Chung SM, Kim HS, Lee JH, Jeong SW, Kim IK, Kim JJ, Kim KS, Kwon OJ

When we treated rat bone marrow stromal cells (rBMSCs) with neuronal differentiation induction media, typical unfolded protein response (UPR) was observed. BIP/GRP78 protein expression was time-dependently increased, and three branches...
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Purification and characterization of recombinant murine endostatin in E. coli

You WK, So SH, Lee H, Park SY, Yoon MR, Chang SI, Kim HK, Joe YA, Hong YK, Chung SI

  • KMID: 1029927
  • Exp Mol Med.
  • 1999 Dec;31(4):197-202.
Endostatin, a carboxyl-terminal fragment of collagen XVIII is known as an anti-angiogenic agent, that specifically inhibits the proliferation of endothelial cell and the growth of several primary tumor....
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