- Regulation of Protein Degradation by Proteasomes in Cancer
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Jang HH
- KMID: 2447446
- J Cancer Prev.
- 2018 Dec;23(4):153-161.
- doi: 10.15430/JCP.2018.23.4.153
Imbalance of protein homeostasis (proteostasis) is known to cause cellular malfunction, cell death, and diseases. Elaborate regulation of protein synthesis and degradation is one of the important processes in maintaining... -
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- Proteolytic Regulation of Retinoblastoma Family Protein p107 by Ubiquitin - proteasome Pathway
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Jang JS, Park BK, Hwang SG
- KMID: 2175114
- J Korean Cancer Assoc.
- 2000 Apr;32(2):417-421.
PURPOSE: Proteolysis is an important way to regulate cell cycle regulatory proteins. Ubiquitin- proteasome pathway regards as highly selective proteolytic machinary mostly in physiological state. We investigated the role of ubiquitin-proteasome pathway... -
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- Changes in expression of proteasome in rats at different stages of atherosclerosis
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Ismawati , Oenzil F, Yanwirasti , Yerizel E
- KMID: 2308916
- Anat Cell Biol.
- 2016 Jun;49(2):99-106.
- doi: 10.5115/acb.2016.49.2.99
It has been suggested that proteasome system has a role in initiation, progression, and complication stages of atherosclerosis. Although there is still controversy, there has been no research that compares... -
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- Inhibition of the 26S and 20S Proteasomes by the Site-specific Inhibitors
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Woo KM
- KMID: 2437766
- Soonchunhyang Med Sci.
- 2018 Jun;24(1):47-54.
- doi: 10.0000/sms.2018.24.1.47
OBJECTIVE: The study was performed to establish the purification processes of both 26S and 20S proteasomes, also to investigate the inhibitory properties and patterns of two different proteasome inhibitors on... -
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- Etiology and Pathogenesis of Parkinson's Disease
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Kim YJ
- KMID: 2137931
- J Korean Neurol Assoc.
- 2004 Oct;22(5):421-432.
Efforts to find etiologies and understand pathogenesis of Parkinson's disease (PD) have progressed over decades from epidemiological studies or biochemical studies on brain tissues of PD to discovering genes responsible... -
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- The Ubiquitin-Proteasome System and F-box Proteins in Pathogenic Fungi
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Liu TB, Xue C
- KMID: 2312649
- Mycobiology.
- 2011 Dec;39(4):243-248.
The ubiquitin-proteasome system is one of the major protein turnover mechanisms that plays important roles in the regulation of a variety of cellular functions. It is composed of E1 (ubiquitin-activating... -
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- Changes in Proteasome Concentrations in Whole Blood and Packed Red Blood Cell Units during Storage
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Kim YK, Suh JS
- KMID: 1440718
- Korean J Blood Transfus.
- 2012 Apr;23(1):20-27.
BACKGROUND: Proteasomes are multi-subunit enzyme complexes present in the cytoplasm and nucleus of eukaryotic cells. Proteasomes are involved in the pathophysiological process resulting in development of many diseases. Release of... -
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- Effect of Lactacystin on the Sulindac-Induced Apoptosis Mechanisms in HT-29 Cells
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Kim JM, Park KJ, Kim SH, Choi HJ
- KMID: 2334296
- J Korean Soc Coloproctol.
- 2003 Apr;19(2):61-66.
PURPOSE: One of possible mechanisms of the antineoplastic effect by nonsteroidal anti-inflammatory drugs (NSAIDs) is an induction of apoptosis. The NSAIDs-induced apoptosis appears to be caspase- and mitochondria-dependent. The ubiquitin-proteasome... -
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- Inhibitory Effect of Apocynin on Proteasome Inhibition-Induced Apoptosis in Differentiated PC12 Cells
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Kang JH, Han SW, Han JH, Kim DE, Lee CS
- KMID: 2163256
- J Korean Neurol Assoc.
- 2016 May;34(2):116-123.
- doi: 10.17340/jkna.2016.2.5
BACKGROUND: The dysfunction of the proteasome system has been implicated in neuronal degeneration. Apocynin, a specific inhibitor for nicotinamide adenine dinucleotide phosphate oxidase, has anti-inflammatory and anti-oxidant effects. However, the... -
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- Apoptotic Effect of Combination Treatment with a Proteasome Inhibitor, Lactacystin, and a Histone Deacetylase Inhibitor, Trichostatin A, on MCF-7 Cells
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Kim GC, Shin YJ, Kim IR, Lee MH, Hwang YS, Gil YG, Park BS
- KMID: 1510218
- Korean J Anat.
- 2006 Dec;39(6):443-452.
Although much information has been accumulated about the synergistic interaction of proteasome inhibitors and HDAC inhibitors to induce apoptosis in a certain type of cells, much less is known currently... -
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- The Mechanism of Proteasome Inhibitor-Induced Apoptosis in Lung Cancer Cells
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Kim CH, Lee KH, Lee CT, Kim YW, Han SK, Shim YS, Yoo CG
- KMID: 2318413
- Tuberc Respir Dis.
- 2003 Apr;54(4):403-414.
BACKGROUND: Proteasome inhibitors can promote either cell survival or programmed cell death, depending on both the specific type and proliferative status of the cell. However, it is not well known... -
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- HIF-1alpha Upregulation due to Depletion of the Free Ubiquitin Pool
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Kim J, So D, Shin HW, Chun YS, Park JW
- KMID: 2344170
- J Korean Med Sci.
- 2015 Oct;30(10):1388-1395.
- doi: 10.3346/jkms.2015.30.10.1388
Hypoxia-inducible factor 1alpha (HIF-1alpha), which transactivates a variety of hypoxia-induced genes, is rapidly degraded under nomoxia through the hydroxylation-ubiquitination-proteasome pathway. In this study, we addressed how HIF-1alpha is stabilized by... -
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- Update on the Treatment of Acute and Chronic Antibody-mediated Rejection
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Park KT, Jung CW, Kim MG
- KMID: 1488436
- J Korean Soc Transplant.
- 2013 Mar;27(1):6-14.
- doi: 10.4285/jkstn.2013.27.1.6
Antibody-mediated rejection (AMR) by preformed and/or de novo human leukocyte antigen alloantibodies is a leading cause of early and late allograft loss. In this review, we describe strategic approaches to... -
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- A Comparative Study of Gene Microarray between Normal and Diabetic Keratocyte in Rat Cornea
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Lee JS, Lee JR, Jung SC, Oum BS
- KMID: 2125578
- J Korean Ophthalmol Soc.
- 2003 Jul;44(7):1629-1638.
PURPOSE: To differentiate the genes that are up-regulated or down-regulated and the cellular morphology in the corneal stromal cells between normal and diabetic rat. METHODS: After isolation with trizol (GIBCO,... -
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- Mechanisms of Muscle Wasting in Patients with Sepsis
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Lee GD, Kim HC
- KMID: 2301449
- Korean J Crit Care Med.
- 2010 Mar;25(1):9-15.
- doi: 10.4266/kjccm.2010.25.1.9
Muscle wasting is commonly seen in patients with sepsis as a consequence of the catabolic response in skeletal muscle. Muscle wasting can occur in cases that have an imbalance between... -
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- Role of a 19S Proteasome Subunit- PSMD10(Gankyrin) in Neurogenesis of Human Neural Progenitor Cells
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Sahu I, Nanaware P, Mane M, Mulla SW, Roy S, Venkatraman P
- KMID: 2465887
- Int J Stem Cells.
- 2019 Nov;12(3):463-473.
- doi: 10.15283/ijsc19007
PSMD10(Gankyrin), a proteasome assembly chaperone, is a widely known oncoprotein which aspects many hall mark properties of cancer. However, except proteasome assembly chaperon function its role in normal cell function... -
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- Selective Susceptibility of Human Dopaminergic Neural Stem Cells to Dopamine-Induced Apoptosis
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Jeon SM, Cheon SM, Bae HR, Kim JW, Kim SU
- KMID: 1460760
- Exp Neurobiol.
- 2010 Dec;19(3):155-164.
- doi: 10.5607/en.2010.19.3.155
Dysfunctions of ubiquitin-proteasome system and toxicity of dopamine have been known as the key mechanisms in the pathogenesis of Parkinson's disease (PD) and proteasome inhibitors are widely used in experimental... -
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- A Case of Bortezomib-Associated Cutaneous Lymphocytic Vasculitis
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Lee KJ, Kim JE, Park HJ, Lee JY, Cho BK
- KMID: 2247734
- Korean J Dermatol.
- 2009 Dec;47(12):1392-1396.
Bortezomib (Velcade(R)) is a newly developed chemotherapeutic agent that is mainly used for the treatment of multiple myeloma. It is a selective and reversible inhibitor of proteasome, which is a... -
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- DNA-Damage Inducible 1 is a Property of Human Non-Small Cell Lung Cancer
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Lee JY, Kang E, Lim BJ, Chang YS, Kim SK
- KMID: 2319731
- Tuberc Respir Dis.
- 2012 Feb;72(2):124-131.
BACKGROUND: DNA damage-inducible 1 (Ddi1), one of the ubiquitin-like and ubiquitin-associated family of proteins, may function in the regulation of the ubiquitin-proteasome pathway, which has been validated as a target... -
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- Effects of a Proteasome Inhibitor on Cardiomyocytes in a Pressure-Overload Hypertrophy Rat Model: An Animal Study
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Kim IS, Jo WM
- KMID: 2381896
- Korean J Thorac Cardiovasc Surg.
- 2017 Jun;50(3):144-152.
- doi: 10.5090/kjtcs.2017.50.3.144
BACKGROUND: The ubiquitin-proteasome system (UPS) is an important pathway of proteolysis in pathologic hypertrophic cardiomyocytes. We hypothesize that MG132, a proteasome inhibitor, might prevent hypertrophic cardiomyopathy (CMP) by blocking the... -
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