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Prebiotics in the Infant Microbiome: The Past, Present, and Future

Miqdady M, Al Mistarihi J, Azaz A, Rawat D

The latest definition of a prebiotic is “a substrate that is selectively utilized by host microorganisms conferring a health benefit”; it now includes non-food elements and is applicable to extra-intestinal...
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Visceral Pain and Gastrointestinal Microbiome

Chichlowski M, Rudolph C

  • KMID: 2381249
  • J Neurogastroenterol Motil.
  • 2015 Apr;21(2):172-181.
  • doi: 10.5056/jnm15025
A complex set of interactions between the microbiome, gut and brain modulate responses to visceral pain. These interactions occur at the level of the gastrointestinal mucosa, and via local neural,...
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Effect of Diet on the Gut Microbiota Associated with Obesity

Kim B, Choi HN, Yim JE

Obesity is abnormal or excessive fat accumulation that is associated with progression of metabolic diseases including type 2 diabetes mellitus, cardiovascular disease, nonalcoholic fatty liver disease, and cancer. Gut microbiota...
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Pharmabiotic Manipulation of the Microbiota in Gastrointestinal Disorders: A Clinical Perspective

Giron F, Quigley EM

  • KMID: 2417380
  • J Neurogastroenterol Motil.
  • 2018 Jul;24(3):355-366.
  • doi: 10.5056/jnm18004
The advent and widespread availability of high-throughput technology has revolutionized the assessment of the communities of microorganisms that inhabit the gastrointestinal tract––the gut microbiota. As our understanding of the role...
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Gut Microbiota and Metabolic Disorders

Hur KY, Lee MS

Gut microbiota plays critical physiological roles in the energy extraction and in the control of local or systemic immunity. Gut microbiota and its disturbance also appear to be involved in...
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Intestinal Microbiota in Preterm Infants and Probiotics Use for Disease Prevention

Kim ES

Infectious complications such as necrotizing enterocolitis (NEC) or neonatal sepsis are main causes of mortality and disability in very low birth weight infants (VLBWIs). Because preterm infants are exposed to...
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Effects of Soyoligosaccharide Intake on Fecal Bifidobacteria and Lipid Concentration in Korean Young Women

Bang MH, Kim WK

  • KMID: 1991971
  • Korean J Nutr.
  • 2004 Oct;37(8):662-668.
This study investigated the effects of soyoligosaccharide consumption on feces bifidobacteria proliferation and feces lipid profiles in Korean young women. Eight healthy young women (25 - 34 years) were fed...
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Role of Gut Microbiota in Type 2 Diabetes Mellitus and Its Complications: Novel Insights and Potential Intervention Strategies

Woldeamlak B, Yirdaw K, Biadgo B

Type 2 diabetes mellitus has become one of the fastest growing public health problems worldwide. The disease is believed to involve a complex process involving genetic susceptibility and environmental factors....
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Prophylactic efficacy of probiotics on travelers' diarrhea: an adaptive meta-analysis of randomized controlled trials

Bae JM

OBJECTIVES: The 2017 guideline for the prevention of travelers' diarrhea (TD) by the International Society of Travel Medicine suggested that ‘there is insufficient evidence to recommend the use of commercially...
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An update on necrotizing enterocolitis: pathogenesis and preventive strategies

Lee JH

Necrotizing enterocolitis (NEC) is one of the most critical morbidities in preterm infants. The incidence of NEC is 7% in very-low-birth-weight infants, and its mortality is 15 to 30%. Infants...
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Probiotics as Complementary Treatment for Metabolic Disorders

Le Barz M, Anhe FF, Varin TV, Desjardins Y, Levy E, Roy D, Urdaci MC, Marette A

Over the past decade, growing evidence has established the gut microbiota as one of the most important determinants of metabolic disorders such as obesity and type 2 diabetes. Indeed, obesogenic...
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A Synbiotic Infant Formula with High Magnesium Content Improves Constipation and Quality of Life

Xinias I, Analitis A, Mavroudi A, Roilides I, Lykogeorgou M, Delivoria , Milingos V, Mylonopoulou M, Vandenplas Y

PURPOSE: To evaluate the efficacy of synbiotic formula with partial whey hydrolysate and high magnesium content in infants presenting with functional constipation. METHODS: Sixty-five infants with functional constipation were included. Forty...
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Innovative Dietary Intervention Answers to Baby Colic

Xinias I, Analitis A, Mavroudi A, Roilides I, Lykogeorgou M, Delivoria , Milingos V, Mylonopoulou M, Vandenplas Y

PURPOSE: The purpose of this paper is to evaluate the efficacy of a lactose- reduced synbiotic partial whey hydrolysate in formula fed infants presenting with colic and the impact of...
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Safety of a New Synbiotic Starter Formula

Vandenplas Y, Analitis A, Tziouvara , Kountzoglou A, Drakou A, Tsouvalas , Mavroudi A, Xinias I

PURPOSE: Breastfeeding is the best way to feed all infants, but not all infants can be (exclusively) breastfed. Cow's milk based infant formula is the second choice infant feeding. METHODS: The...
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Growth and Tolerance Assessment of a Lutein-fortified Infant Formula

Kon IY, Gmoshinskaya MV, Safronova , Alarcon P, Vandenplas Y

  • KMID: 2315474
  • Pediatr Gastroenterol Hepatol Nutr.
  • 2014 Jun;17(2):104-111.
PURPOSE: To evaluate safety, gastrointestinal tolerance, and growth of a new experimental starter formula (NESF) fortified with lutein, prebiotics, probiotics, nucleotides and beta-carotene, fed to infants within the first months...
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Dosage-Related Prebiotic Effects of Inulin in Formula-Fed Infants

Oswari H, Widodo AD, Handayani , Juffrie M, Sundjaya T, Bindels J, Hegar B

PURPOSE: The aim of this study was to identify the minimally meaningful dosage of inulin leading to a prebiotic effect in Indonesian infants. METHODS: In a randomized controlled double-blinded, parallel, 3-arm...
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Chemopreventive and metabolic effects of inulin on colon cancer development

Hijova E, Szabadosova V, Stofilova , Hrckova G

Prebiotics modulate microbial composition and ensure a healthy gastrointestinal tract environment that can prevent colon cancer development. These natural dietary compounds are therefore potential chemopreventive agents. Thirty Sprague-Dawley rats (4...
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Associations between Dietary Allium Vegetables and Risk of Breast Cancer: A Hospital-Based Matched Case-Control Study

Pourzand A, Tajaddini , Pirouzpanah S, Asghari-Jafarabadi M, Samadi N, Ostadrahimi AR, Sanaat Z

PURPOSE: The protective effect of Allium vegetables against carcinogenesis has been reported in experimental studies particularly focusing on the gut. Therefore, we conducted a hospital-based matched case-control study to explore...
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Effect of dual-type oligosaccharides on constipation in loperamide-treated rats

Han SH, Hong KB, Kim EY, Ahn SH, Suh HJ

BACKGROUND/OBJECTIVES: Constipation is a condition that can result from intestinal deformation. Because humans have an upright posture, the effects of gravity can cause this shape deformation. Oligosaccharides are common prebiotics...
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Microbiota, a key player in alcoholic liver disease

Cassard AM, Ciocan D

Alcoholic liver disease (ALD) is a major cause of morbidity and mortality worldwide. Only 20% of heavy alcohol consumers develop alcoholic liver cirrhosis. The intestinal microbiota (IM) has been recently...
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