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The Development of Injectable Intraocular Lens Using Thermosensitive Polymeric Hydrogel in Vitro and in Vivo

Han YK, Kwon JW, Kim HY, Kim JS, Cho CS, Wee WR, Lee JH

  • KMID: 2206692
  • J Korean Ophthalmol Soc.
  • 2003 Sep;44(9):2137-2143.
PURPOSE: To evaluate the compatibility of poloxamer hydrogel as a material for the injectable intraocular lens in in vivo and in vitro model. METHODS: We determined the appropriate concentration of...
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IrreVersible Gel Tansformation of Injectavble Intraocular Lens by Photoinitiator and UV Irradiation in Rabbits

Kwon JW, Han YK, Lee W, Kim HY, Kim JS, Cho CS, Paik SJ, Byun SW, Cho DI, Lee JH, Wee WR

  • KMID: 2337149
  • J Korean Ophthalmol Soc.
  • 2004 Sep;45(9):1535-1540.
PURPOSE: This study was designed to induce irreVersible gel formation of poloxamer, the thermosensitive polymer hydrogel, by using photoinitiator and UV irradiation, and to verify the biocompatibility and usability of...
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An Experimental Study on the Wound Healing Effects of Recombinant Human Epidermal Growth Factors According to Poloxamer Concentrations in Full-thickness Excisional Wound Models of Rats

Baek RM, Chung WJ, Lee YJ, Lee JH, Im TG, Yoon BH

  • KMID: 2098271
  • J Korean Soc Plast Reconstr Surg.
  • 2003 Mar;30(2):209-216.
This study was designed to investigate the optimal poloxamer concentration in the mixed solution of recombinant human epidermal growth factor and poloxamer which can be effective in the wound healing...
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Anti-adhesive Effect of Poloxamer/Alginate/CaCl2 Mixture in the Rat Model

Kwon SW, Lim SH, Lee YW, Lee YG, Chu BY, Lee JH, Lee YM

  • KMID: 1844904
  • J Korean Surg Soc.
  • 2006 Oct;71(4):280-287.
PURPOSE: The occurrence of post-surgical adhesion is still a major cause of postoperative morbidity due to the lack of satisfactory treatment or prophylaxis. Several adhesion barriers have been developed in...
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The Effect of Poloxamer 407-Based Hydrogel on the Osteoinductivity of Demineralized Bone Matrix

Lee JH, Baek HR, Lee KM, Lee HK, Im SB, Kim YS, Lee JH, Chang BS, Lee CK

BACKGROUND: Demineralized bone matrix (DBM) is used for bone healing due to its osteoinductivity, but it requires a carrier for clinical application. Here, we report the effects on the osteoinductivity...
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Berberine Ameliorates Brain Inflammation in Poloxamer 407-Induced Hyperlipidemic Rats

Kim M, Kim TW, Kim CJ, Shin MS, Hong M, Park HS, Park SS

PURPOSE: Hyperlipidemia, which promotes the development of atherosclerosis, ischemic stroke, and other forms of brain injury, can be induced by poloxamer-407. Berberine is a primary pharmacological active component of Coptidis...
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The cardioprotective effect of microemulsion propofol against ischemia and reperfusion injury in isolated rat heart

Hur MJ, Kim H, Lee DK, Lim SH

BACKGROUND: Lipid-emulsion propofol (LP) has cardioprotective effects against ischemia-reperfusion injury, but it has lipid-related side effects. Microemulsion propofol (MP) is a lipid-free propofol emulsified with 10% purified poloxamer 188 (PP188)....
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Poloxamer 407 Hydrogels for Intravesical Instillation to Mouse Bladder: Gel-Forming Capacity and Retention Performance

Kim SH, Kim SR, Yoon HY, Chang IH, Whang YM, Cho MJ, Kim MJ, Kim SY, Lee SJ, Choi YW

PURPOSE: Poloxamer 407 (P407) thermo-sensitive hydrogel formulations were developed to enhance the retention time in the urinary bladder after intravesical instillation. MATERIALS AND METHODS: P407 hydrogels (P407Gels) containing 0.2 w/w% fluorescein...
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Platelet-Derived Growth Factor-BB-Immobilized Asymmetrically Porous Membrane for Enhanced Rotator Cuff Tendon Healing

Min HK, Kwon OS, Oh SH, Lee JH

Rotator cuff tear is a common musculoskeletal disease that often requires surgical repair. Despite of recent advances in surgical techniques, the re-tear rate of the rotator cuff tendon is very...
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Experimental Transscleral Ocular Drug Delivery: Use of Pluronic F-127 Gel and Fibrin Glue as a Sustained Release System

Lee SB, Kwon JY, Edelhauser HF

  • KMID: 2206121
  • J Korean Ophthalmol Soc.
  • 2002 Jul;43(7):1276-1286.
PURPOSE: The purpose of this study was to evaluate the effect of two sustained release systems (Pluronic F-127 gel and Fibrin glue) on the diffusion of dexamethasone across the human...
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Injectable Cartilage Tissue Engineering Techniques Utilizing Fibrin Glue, Liquid Alginate and Pluronic F-127

Jeong JH, Kim KH, Kim HH, Moon YM, Lee DJ, Choi JH, Kim SY

  • KMID: 2322317
  • J Korean Soc Plast Reconstr Surg.
  • 2003 Jul;30(4):465-473.
Recently, a cartilage tissue utilizing the scaffold with liquid has been introduced for clinical application. In this study, three different bio-materials--fibrin glue, liquid alginate, and Pluronic F-112--were used to observe...
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Efficacy of a Multiplex Paclitaxel Emission Stent Using a Pluronic® Mixture Membrane versus a Covered Metal Stent in Malignant Biliary Obstruction: A Prospective Randomized Comparative Study

Jang SI, Lee SJ, Jeong S, Lee DH, Kim MH, Yoon HJ, Lee DK

BACKGROUND/AIMS: A drug-eluting stent for unresectable malignant biliary obstruction was developed to increase stent patency by preventing tumor ingrowth. The safety and efficacy of a new generation of metallic stents...
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Human Urine-derived Stem Cells Seeded Surface Modified Composite Scaffold Grafts for Bladder Reconstruction in a Rat Model

Lee JN, Chun SY, Lee HJ, Jang YJ, Choi SH, Kim DH, Oh SH, Song PH, Lee JH, Kim JK, Kwon TG

We conducted this study to investigate the synergistic effect of human urine-derived stem cells (USCs) and surface modified composite scaffold for bladder reconstruction in a rat model. The composite scaffold...
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