J Korean Ophthalmol Soc.  2003 Sep;44(9):2137-2143.

The Development of Injectable Intraocular Lens Using Thermosensitive Polymeric Hydrogel in Vitro and in Vivo

• Han YK
• Kwon JW
• Kim HY
• Kim JS
• Cho CS
• Wee WR
• Lee JH

Abstract

PURPOSE
To evaluate the compatibility of poloxamer hydrogel as a material for the injectable intraocular lens in in vivo and in vitro model. METHODS: We determined the appropriate concentration of poloxamer hydrogel for injection through the examination of transparency and gelling temperature of this material and assess the technique of refilling the lens capsule and the postoperative findings.
RESULTS
Poloxamer hydrogel showed excellent transparency compared with balanced salt solution(BSS) in air vinyl and 20% was identified as an appropriate concentration for direct lens refilling material. In vivo study, we injected poloxamer into the capsular bag after performing endocapsular phacoemulsification through the small anterior capsulotomy site. At 3 months follow up, we confirmed the excellent transparency and biocompatibility of poloxamer hydrogel.
CONCLUSIONS
Poloxamer hydrogel was identified as an appropriate material for direct lens refilling material.

Keyword

Direct lens refilling material; Injectable intraocular lens; Poloxamer hydrogel

MeSH Terms

Follow-Up Studies
Hydrogel*
Lenses, Intraocular*
Phacoemulsification
Poloxamer
Polymers*
Hydrogel
Poloxamer
Polymers