J Korean Ophthalmol Soc.
2004 Sep;45(9):1535-1540.
IrreVersible Gel Tansformation of Injectavble Intraocular Lens by Photoinitiator and UV Irradiation in Rabbits
- Affiliations
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- 1Department of Ophthalmology, Seoul National University College of Medicine, Korea. wrwee@snu.ac.kr
- 2Seoul Artificial Eye Center, Clinical Research Institute, Seoul National University Hospital, Seoul, Korea.
- 3Department of Ophthalmology, Seoul Municipal Boramae Hospital, Seoul, Korea.
- 4Department of Ophthalmology, Kangnam Sacred Heart Hospital, College of Medicine, Hallym University, Seoul, Korea.
- 5School of Agricultural Biotechnology, Seoul National University, Seoul, Korea.
- 6School of Electrical Engineering and Computer Science, Seoul National University, Seoul, Korea.
Abstract
- PURPOSE
This study was designed to induce irreVersible gel formation of poloxamer, the thermosensitive polymer hydrogel, by using photoinitiator and UV irradiation, and to verify the biocompatibility and usability of poloxamer as an injectable intraocular lens material through long-term observation in vivo. METHODS: Endocapsular phacoemulsification of lens was performed in rabbits and 25% poloxamer mixed with various concentrations of photoinitiator was injected into the capsular bag through a small capsulorhexis site. Then, the whole eye was irradiated with UV light for 5 minutes. The irreversibility and transparency of the post-operative poloxamer and the effects on the conjunctiva, cornea, iris, vitreous humor and retina were observed. RESULTS: As the results of this experiment using poloxamer 25% and photoinitiator 0.01%, the poloxamer remained transparent in the lens capsule for more than six months after the operation. No inflammatory response or toxicity was observed on the conjunctiva, cornea, iris, vitreous humor or retina. CONCLUSIONS: This study demonstrated the possibility of poloxamer as a new material for the injectable intraocular lens. Further study, however, is necessary.
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