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Climate change, air pollution, and biodiversity in Asia Pacific: impact on allergic diseases

Pawankar R

No abstract available.
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Overview on the pathomechanisms of allergic rhinitis

Pawankar R, Mori S, Ozu C, Kimura S

Allergic rhinitis a chronic inflammatory disease of the upper airways that has a major impact on the quality of life of patients and is a socio-economic burden. Understanding the underlying...
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Increased Expression and Role of Thymic Stromal Lymphopoietin in Nasal Polyposis

Kimura S, Pawankar R, Mori S, Nonaka M, Masuno S, Yagi T, Okubo K

PURPOSE: Nasal polyposis is a chronic inflammatory disease of the upper airways often associated with asthma and characterized by markedly increased numbers of eosinophils, Th2 type lymphocytes, fibroblasts, goblet cells...
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Decreased Expression of FOXP3 in Nasal Polyposis

Roongrotwattanasiri K, Pawankar R, Kimura S, Mori S, Nonaka M, Yagi T

PURPOSE: The pathogenesis of nasal polyposis (NP) is unclear. Eosinophils and mast cells are considered to play important roles in this process. In addition, the levels of Th2-type cells are...
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Expression and Roles of MMP-2, MMP-9, MMP-13, TIMP-1, and TIMP-2 in Allergic Nasal Mucosa

Mori S, Pawankar R, Ozu C, Nonaka M, Yagi T, Okubo K

PURPOSE: Allergic rhinitis (AR) and asthma share many characteristics, but structural changes are observed far less often in AR. Matrix metalloproteinases (MMPs) constitute a family of Zn-dependent endopeptidases that can...
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Improvement of Eosinophilic Otitis Media by Optimized Asthma Treatment

Tanaka Y, Nonaka M, Yamamura Y, Tagaya E, Pawankar R, Yoshihara

Eosinophilic otitis media (EOM) shows a very high rate of association with asthma, and intractable otitis media involves marked eosinophil infiltration into the middle ear. The middle ear space is...
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Asia Pacific Association of Allergy Asthma and Clinical Immunology White Paper 2020 on climate change, air pollution, and biodiversity in Asia-Pacific and impact on allergic diseases

Pawankar R, Wang JY, Wang IJ, Thien F, Chang YS, Latiff AH, Fujisawa T, Zhang L, Thong BY, Chatchatee P, Leung TF, Kamchaisatian W, Rengganis , Yoon HJ, Munkhbayarlakh S, Recto MT, Neo AG, Le Pham D, Lan LT, Davies JM, Oh JW

Air pollution, climate change, and reduced biodiversity are major threats to human health with detrimental effects on a variety of chronic noncommunicable diseases in particular respiratory and cardiovascular diseases. The...
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Basophils are increased and express increased levels of interleukin-4 in the parotid lesions of Kimura disease

Nonaka M, Sakitani E, Ono E, Yamamura Y, Seo Y, Shibata N, Pawankar R, Yoshihara

BACKGROUND: Kimura disease (KD) is a systemic soft-tissue disease that leads to formation of painless masses in lymph nodes, with the highest predilection for the head and neck and especially...
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Optimal control of asthma improved eosinophilic otitis media

Seo Y, Nonaka M, Yamamura Y, Pawankar R, Tagaya E

BACKGROUND: Eosinophilic otitis media (EOM) is often associated with comorbid asthma. The middle ear cavity is part of the upper airway. Therefore, EOM and asthma can be considered to be...
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A case of anhidrotic ectodermal dysplasia presenting with pyrexia, atopic eczema, and food allergy

Suzuki T, Tajima H, Migita M, Pawankar R, Yanagihara T, Fujita A, Shima Y, Yanai E, Katsube Y

Anhidrotic ectodermal dysplasia (AED) is a rare hereditary disorder with a triad of sparse hair, dental hypoplasia, and anhidrosis. Here we report a case of AED with food allergy and...
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Climate Change and Air Pollution: Effects on Respiratory Allergy

D'Amato G, Pawankar R, Vitale C, Lanza M, Molino A, Stanziola , Sanduzzi A, Vatrella A, D'Amato M

A body of evidence suggests that major changes involving the atmosphere and the climate, including global warming induced by anthropogenic factors, have impact on the biosphere and human environment. Studies...
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Drug hypersensitivity reactions in Asia: regional issues and challenges

Thong BY, Lucas M, Kang HR, Chang YS, Li PH, Tang MM, Yun J, Fok JS, Kim BK, Nagao M, Rengganis , Tsai YG, Chung WH, Yamaguchi , Rerkpattanapipat T, Kamchaisatian W, Leung TF, Yoon HJ, Zhang L, Latiff AH, Fujisawa T, Thien F, Castells M, Demoly P, Wang JY, Pawankar R

There are geographical, regional, and ethnic differences in the phenotypes and endotypes of patients with drug hypersensitivity reactions (DHRs) in different parts of the world. In Asia, aspects of drug...
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