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History and Future of Treatment for Acute Stage Kawasaki Disease

Ishii M, Ebato T, Kato H

Kawasaki disease is a form of vasculitis, mainly in small and medium arteries of unknown origin, occurring frequently in childhood. It is the leading form of childhood-onset acquired heart disease...
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Antioxidant, Anti-Melanogenic and Anti-Wrinkle Effects of Phellinus vaninii

Im KH, Baek SA, Choi J, Lee TS

In this study, the antioxidant, anti-xanthine oxidase, anti-melanogenic and anti-wrinkle effects of methanol (ME) and hot water (HE) extracts from the fruiting bodies of Phellinus vaninii were investigated. The 1,1-diphenyl-2-picryl-hydrazyl...
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Clinical Significance of Inflammatory Biomarkers in Acute Pediatric Diarrhea

Park Y, Son M, Jekarl DW, Choi HY, Kim SY, Lee S

PURPOSE: The aim of this study was to evaluate the clinical significance of inflammatory biomarkers in acute infectious diarrhea among children. METHODS: Clinical parameters including fever, bacterial and viral etiology based...
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Histological Comparison of Papain-induced and Elastase-induced Saccular Aneurysms in Rabbits

Park H, Kim M, Kim SY, Lee SL, Lee HC, Lee WJ, Lee JH

A saccular aneurysm is a localized, pouch arterial abnormality, Varous kinds of experimental saccular aneurysm models have been developed to treat aneurysms, and more effective ways to create aneurysm model...
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The activation of NLRP3-inflammsome by stimulation of diesel exhaust particles in lung tissues from emphysema model and RAW 264.7 cell line

Uh ST, Koo SM, Kim Y, Kim K, Park S, Jang AS, Kim D, Kim YH, Park CS

BACKGROUND/AIMS: Diesel exhaust particles (DEPs) lead to elevation of reactive oxygen species, which can activate the nucleotide-binding oligomerization domain-like receptor (NLR) family members containing the pyrin domain 3 (NLRP3)-inf lammasome....
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Antioxidant and Antiaging Assays of Hibiscus sabdariffa Extract and Its Compounds

Widowati W, Rani AP, Hamzah RA, Arumwardana S, Afifah E, Kusuma HS, Rihibiha D, Nufus H, Amalia A

Skin aging is a complex biological process due to intrinsic and extrinsic factors. Free radical oxidative is one of extrinsic factors that induce activation of collagenase, elastase and hyaluronidase. Natural...
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Oral Administration of Glycine and Leucine Dipeptides Improves Skin Hydration and Elasticity in UVB-Irradiated Hairless Mice

Park JI, Lee JE, Shin HJ, Song S, Lee WK, Hwang JS

Placenta is a special organ that contains many nutrients such as growth factors, minerals, and bioactive peptides. Dipeptides of glycine and leucine are major components of porcine placenta extracts (PPE)...
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Therapeutic effects of adipose-derived stem cells pretreated with pioglitazone in an emphysema mouse model

Hong Y, Kim YS, Hong SH, Oh YM

There is no therapy currently available that influences the natural history of disease progression in patients with chronic obstructive pulmonary disease (COPD). Although stem cell therapy is considered a potential...
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Adenophora remotiflora protects human skin keratinocytes against UVB-induced photo-damage by regulating antioxidative activity and MMP-1 expression

Kim HK

BACKGROUND/OBJECTIVES: Chronic ultraviolet (UV) exposure-induced reactive oxygen species (ROS) are commonly involved in the pathogenesis of skin damage by activating the metalloproteinases (MMP) that break down type I collagen. Adenophora...
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A New Flow-Diverter (the FloWise): In-Vivo Evaluation in an Elastase-Induced Rabbit Aneurysm Model

Kim BM, Kim DJ, Kim DI

OBJECTIVE: We aimed to evaluate the efficacy and safety of a newly developed, partially retrievable flow-diverter (the FloWise) in an elastase-induced rabbit aneurysm model. MATERIALS AND METHODS: We developed a partially...
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Extraction conditions of white rose petals for the inhibition of enzymes related to skin aging

Choi EK, Guo H, Choi JK, Jang SK, Shin K, Cha YS, Choi Y, Seo DW, Lee YB, Joo SS, Kim YB

In order to assess inhibitory potentials of white rose petal extracts (WRPE) on the activities of enzymes related to dermal aging according to the extraction conditions, three extraction methods were...
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The Therapeutic Effects of Optimal Dose of Mesenchymal Stem Cells in a Murine Model of an Elastase Induced-Emphysema

Kim YS, Kim JY, Huh JW, Lee SW, Choi SJ, Oh YM

BACKGROUND: Chronic obstructive pulmonary disease is characterized by emphysema, chronic bronchitis, and small airway remodeling. The alveolar destruction associated with emphysema cannot be repaired by current clinical practices. Stem cell...
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Changes of Alpha1-Antitrypsin Levels in Allergen-induced Nasal Inflammation

Shin SY, Choi GS, Lee KH, Kim SW, Won KY, Lee JH, Cho JS, Park HS

  • KMID: 2166459
  • Clin Exp Otorhinolaryngol.
  • 2011 Mar;4(1):33-39.
OBJECTIVES: Alpha1-antitrypsin (AAT) is the main inhibitor of human neutrophil elastase, and plays a role in counteracting the tissue damage caused by elastase in local inflammatory conditions. The study evaluated...
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Effect of bosentan on the production of proinflammatory cytokines in a rat model of emphysema

Gamze K, Mehmet HM, Deveci F, Turgut T, ilhan F, Ozercan I

  • KMID: 1090964
  • Exp Mol Med.
  • 2007 Oct;39(5):614-620.
Endothelin (ET) receptor antagonists have been developed to produce a reduction of ET related effects in various diseases, as well as in animal models of airway inflammation. We aimed to...
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The comparison of IL-6, elastase and alpha1-PI expressions in human chronic periodontitis with type 2 diabetes mellitus

Park JW, Lee JM

No abstract available.
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Pathogenesis and Pathophysiology of Chronic Obstructive Pulmonary Disease (COPD)

Kim WD

  • KMID: 2135206
  • Hanyang Med Rev.
  • 2005 Nov;25(4):15-21.
With the rise in cigarette smoking, COPD has emerged as a critical health problem and unmet medical need worldwide. Much of the information concerning the pathogenesis of COPD comes from...
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The Relationship between Human Neutrophil Elastase and Coronary Arterial Dilatation in Kawasaki Disease

Shim JY, Choi HW, Hong JH, Lee JK, Lee HY

  • KMID: 1607043
  • J Korean Pediatr Soc.
  • 2003 Sep;46(9):903-908.
PURPOSE: Kawasaki disease is notorious for coronary arterial complication which is usually developed as a febrile disease in early childhood. Increased polymorphonucleus(PMN) cell levels in acute phases may be associated...
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The Morphologic Study of Elastic Structures in the Developing Murine Eustachian Tube

Park K, Moon SK, Choung YH, Eum JH, Lee JH

  • KMID: 1923101
  • Korean J Otolaryngol-Head Neck Surg.
  • 2003 Mar;46(3):185-190.
BACKGROUND AND OBJECTIVES: Detailed information on how an epithelial differentiation and elastic structures occurred in the developing eustachian tube would be helpful in understanding both normal physiology and pathology of...
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Effect of Neutrophil Elastase inhibitor, ICI 200,355, on Interleukin-1 Induced acute lung injury in rats

Chung JH, Mun YC, Park HJ, Shin KC, Lee KH

BACKGROUND: Interleukin-1 (IL-1) and neutrophil appear to contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). Elastase, as well as reactive oxygen species released from activated neutrophil, are thought...
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Induced Hypergastrinemia Can Prevent the Pancreatic Atrophy after Pancreatoduodenectomy in Human

Jang JY, Kim SW, Han JK, Park SJ, Park YC, Park YH

  • KMID: 2209426
  • J Korean Surg Soc.
  • 2001 Jul;61(1):95-104.
PURPOSE: Following a pancreatoduodenectomy, atrophy of the distal pancreas commonly occurs. It has been demonstrated that gastrin stimulates the regeneration of the pancreas in animals. This study was undertaken to...
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