Korean J Gastroenterol.  1999 Oct;34(4):528-536.

Clinical Evaluation of the Fecal and Serum Elastase 1 test in the Diagnosis of Chronic Pancreatitis

Abstract

BACKGROUND/AIMS: Indirect pancreatic function tests available currently are unreliable in clinical practice for early chronic pancreatitis because of their low sensitivity in mild and moderate exocrine pancreatic insufficiency. In addition, the measurement of serum amylase and lipase serum levels of levels is not useful in the diagnosis of chronic pancreatitis.
METHODS
We evaluated the sensitivity and specificity of fecal elastase 1 determination in diagnosing pancreatic insufficiency. Concentrations of fecal and serum elastase 1 were measured with enzyme linked immunosorbent assay (ELISA) in 25 patients with chronic pancreatitis, 29 patients with acute pancreatitis and 29 normal controls.
RESULTS
The mean concentration of fecal elastase 1 was 136.8+/-24.7 microgram/g stool in chronic pancreatitis patients, 644.2+/-52.1 microgram/g stool in acute pancreatitis and 649.8+/-56.7 microgram/g stool in control group. When the cut-off value was set at 300 microgram/g stool, the sensitivity and specificity of stool elastase 1 determination were 88% and 94.8%, respectively, in patients with chronic pancreatitis. Significant correlations were found between serum amylase level and serum lipase level (r=0.923, p<0.01). Fecal elastase 1 level was not correlated with serum level of amylase or lipase.
CONCLUSIONS
Fecal elastase 1 determination may be a highly sensitive and specific exocrine pancreatic function test in diagnosing chronic pancreatitis.

Keyword

Chronic pancreatitis; Serum elastase; Fecal elastase 1

MeSH Terms

Amylases
Diagnosis*
Enzyme-Linked Immunosorbent Assay
Exocrine Pancreatic Insufficiency
Humans
Lipase
Pancreatic Elastase*
Pancreatic Function Tests
Pancreatitis
Pancreatitis, Chronic*
Sensitivity and Specificity
Amylases
Lipase
Pancreatic Elastase
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