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Role of the ABCB1 Drug Transporter Polymorphisms in the Pharmacokinetics of Oseltamivir in Humans: a Preliminary Report

Cha YJ, Ghim JL

Oseltamivir is a substrate of P-glycoprotein, an efflux drug transporter encoded by ABCB1. The objective of this study was to assess the role of ABCB1 (c.1236C>T, c.2677G>T/A, and c.3435C>T) polymorphisms...
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Acute Hemorrhagic Colitis Associated with the Use of Oseltamivir

Chung DW, Son HS, Park JH, Jung MK, Jeon SW, Cho CM, Kim SK

  • KMID: 2258866
  • Korean J Med.
  • 2011 Jun;80(Suppl 2):S87-S90.
Oseltamivir is a potent selective neuraminidase enzyme inhibitor and effective against nearly all strains of influenza A and B. The importance of treating influenza has been recognized, and oseltamivir has...
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A Case of Auditory Hallucination after Intake of Oseltamivir for H1N1 Treatment

Kim HG, Kim HJ, Cho YS

  • KMID: 2332761
  • J Korean Soc Emerg Med.
  • 2010 Jun;21(3):402-404.
Unusual neuropsychiatric events related to oseltamivir are very rare but some cases have been reported, mainly in the United States and Japan. Here we present a rare case of auditory...
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Psychiatric Symptoms in a Patient with Influenza A (H1N1) Treated with Oseltamivir (Tamiflu): A Case Report

Jeon SW, Han C

Oseltamivir is the most common antiviral drug used to treat and prevent influenza. Epidemiological studies performed in Japan, the United States, and the United Kingdom indicate that oseltamivir may cause...
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A Case of Bilateral Vestibular Hypofunction Following Oseltamivir Medication

Kim HY, Ahn SK, Hur DG

  • KMID: 1426906
  • Res Vestib Sci.
  • 2013 Mar;12(1):27-30.
The threat of pandemic influenza has focused attention and resources on virus surveillance, prevention, and containment. The World Health Organization has strongly recommended the use of the antiviral drug, Oseltamivir...
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Clinical Use of Tamiflu (Oseltamivir)

Chang MS, Woo JH

Oseltamivir (Tamiflu, the trade name) is a neuraminidase inhibitor used for the treatment and prevention of influenza virus infection as well as those of avian influenza infection. The mechanism of...
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Oseltamivir (Tamiflu) Induced Depressive Episode in a Female Adolescent

Chung S, Joung YS

  • KMID: 2315919
  • Psychiatry Investig.
  • 2010 Dec;7(4):302-304.
Oseltamivir was developed for prophylactic and therapeutic use against influenza, specifically targeting the viral enzyme's highly-conserved active site. In recent years, there have been case reports of neuropsychiatric events during...
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A Case of Oseltamivir-Resistant Pandemic Influenza (H1N1 2009)

Hong HL, Kim JH, Yi HJ, Kwon HH

  • KMID: 2406172
  • Infect Chemother.
  • 2010 Apr;42(2):103-106.
In April 2009, the first swine origin pandemic influenza (H1N1 2009) infection was reported in Mexico and United states and has since spread rapidly worldwide. Finally on June 11, 2009,...
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Psychiatric Symptoms after Taking Oseltamivir in a Child and Its Causality Assessment

Son P, Choi J, Lee S, Park SS, Choi E, Yoo BK, Ji E

Oseltamivir is an antiviral medication prescribed to prevent and treat influenza A and B. A case from a community pharmacy in Korea was reported for an adverse event associated with...
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A Case of Oseltamivir-Resistant Pandemic Influenza (H1N1 2009) in a Patient with Acute Myeloid Leukemia

Lee YH, Kim HY, Kim HS, Uh Y, Kim YK, Kim BR, Jung HY, Kim WT, Yi H

  • KMID: 2406173
  • Infect Chemother.
  • 2010 Apr;42(2):107-111.
Oseltamivir is the drug of choice for patients with pandemic influenza (H1N1 2009). However, sporadic cases of oseltamivir resistance have been described worldwide. Up to March 2010, a total of...
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Acute Hemorrhagic Colitis Induced by Oral Administration of Oseltamivir

Kim HS, Kim MW, Kim SH, Kim G, Lee JH

Oseltamivir has been used as a worldwide preparation for treatment of influenza A and B including H1N1. Gastrointestinal discomforts as like nausea, vomiting are commonly reported but acute hemorrhagic colitis...
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Effectiveness of double-dose oseltamivir for pediatric patients with severe 2009 pandemic influenza A H1N1

Cho HS, Min SR, Lee JH, Ahn SY, Lee HS, Yang JH, Kim JK

PURPOSE: We aimed to evaluate the use and safety of double dose oseltamivir for patients manifesting severe respiratory symptoms or showing no improvement of clinical symptoms after 72 hours' treatment...
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Differences in Clinical Manifestations and Treatment Responses in Influenza Type A and B in a Single Hospital during 2013 to 2015

Lee SM, Park SK, Kim JH, Lee JH, Na SY, Kim DH, Kang EK, Cho SM, Kim HS

PURPOSE: We suspect there is a difference in the clinical manifestations and treatment response to antiviral drugs for influenza A and B. This study was conducted to investigate this difference. METHODS:...
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The Diagnosis and Treatment of Influenza

Lee CS

Influenza viruses cause annual epidemics and occasional pandemics that have claimed the millions of lives. On December 4th 2009, more than 207 countries and overseas territories have reported laboratory confirmed...
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Clinical Effects of Oseltamivir in Children with Influenza in Busan, in the First Half of 2004

Park SK, Choi SY, Kim SM, Kim GH, Jung JH, Choi IJ, Cho KS

  • KMID: 2279053
  • Korean J Pediatr.
  • 2005 Sep;48(9):976-985.
PURPOSE: Although influenza is one of the most important causes of acute respiratory tract infections in children, effective antiviral therapies are not common and there are only a few clinical...
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Clinical Characteristics of Influenza B Virus in Children and the Efficacy of Oseltamivir: Data from Two University Hospitals

Youn SE, Chun JH, Lee KS, Rha YH, Choi SH

PURPOSE: There has been little research regarding the effectiveness of oseltamivir for influenza B infections. We sought to identify the different clinical manifestations between patients treated with and without oseltamivir. METHODS:...
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Clinical Comparison of Influenza A and B Virus Infection in Hospitalized Children

Jung S, Lee JH, Kang JH, Lee HS, Choi JW, Ma SH, Lee J

PURPOSE: The objective of this study was to compare the clinical characteristics of influenza A and B infections and analyze the effect of oseltamivir in hospitalized children. METHODS: We investigated children...
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First Fatal Oseltamivir-Resistant 2009 Pandemic Influenza A (H1N1) Case in an Adult in Korea

Hong SD, Park SH, Kang SJ, Kwon YS, Kee SJ, Park KH, Jung SI, Jang HC

It has been suggested that oseltamivir-resistant influenza viruses harboring the H274/275Y mutation are less virulent than are those that are oseltamivir-sensitive, and fatality attributed to infection with an oseltamivir-resistant virus...
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A Case of High Dose Oseltamivir Treatment in an Influenza A (H1N1) Infected Patient with Severe Graft Versus Host Disease

Kim AR, Kim ES, Pai KS, Park JE

  • KMID: 2168936
  • Clin Pediatr Hematol Oncol.
  • 2011 Apr;18(1):58-61.
Influenza A (H1N1) infection has been noted to be common in the young and high-risk groups for influenza infection, including transplant candidates and recipients. However, the optimal dosage and duration...
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Acute Hemorrhagic Leukoencephalopathy in a Patient with Influenza A and B Coinfection

Park DY, Yoon DY, Kwon JS, Jhang Y

Acute hemorrhagic leukoencephalopathy is a rare condition associated with the influenza virus, but the role of influenza in this condition has not been clarified. We experienced a patient with influenza...
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