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Regenerative Medicine of the Bile Duct: Beyond the Myth

Buisson EM, Jeong J, Kim HJ, Choi D

Cholangiopathies are rare diseases of the bile duct with high mortality rates. The current treatment for cholangiopathies is liver transplantation, but there are significant obstacles including a shortage of donors...
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Diabetes and Alzheimer's Disease: Mechanisms and Nutritional Aspects

Lee HJ, Seo HI, Cha HY, Yang YJ, Kwon SH, Yang SJ

Blood glucose homeostasis is well maintained by coordinated control of various hormones including insulin and glucagon as well as cytokines under normal conditions. However, chronic exposure to diabetic environment with...
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Cervical Bronchogenic Cyst Mimicking Thyroid Cyst

Kang SH, Jin SM, Kim HK, Yoon TM

Bronchogenic cysts are rare congenital malformations that result from an abnormal development of the ventral foregut budding of the tracheobronchial tree at the time of organogenesis. They are usually located...
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Genetics of vesicoureteral reflux and congenital anomalies of the kidney and urinary tract

Lee KH, Gee HY, Shin JI

The definition of congenital anomalies of the kidney and urinary tract (CAKUT) is the disease of structural malformations in the kidney and/or urinary tract containing vesicoureteral reflux (VUR). These anomalies...
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A Pregnant Woman with Type 2 Diabetes Unintentionally Exposed to Metformin and Voglibose until the Second Trimester of Pregnancy: A Case Report

Kim YU, Kwak JH, Yeo SH, Moon SS, Lee YS

Use of oral hypoglycemic agents during pregnant women with type 2 diabetes is controversial due to safety issues. Recently, randomized controlled trials support short-term safety of glyburide and metformin for...
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Comparison of teratogenecity induced by nano- and micro-sized particles of zinc oxide in cultured mouse embryos

Jung AY, Jung KY, Lin C, Yon JM, Lee JG, Lee BJ, Yun YW, Nam SY

The increasing uses of zinc oxide nanoparticles (nZnO) in industrial and personal care products raise possible danger of using nZnO in human. To determine whether ZnO induces size-dependent anomalies during...
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Endoplasmic reticulum stress in periimplantation embryos

Michalak M, Gye MC

Stress coping mechanisms are critical to minimize or overcome damage caused by ever changing environmental conditions. They are designed to promote cell survival. The unfolded protein response (UPR) pathway is...
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Role of the CXC12-CXCR4 Axis and CXCL16 in Inflammatory Bowel Disease

Nakase H, Matsuura M, Mikami S, Uza N, Chiba T

Numerous studies of colitis in IBD (inflammatory bowel diseases) patients and in animal models have demonstrated that both inflammatory cytokines and chemokines are up-regulated in settings of active inflammation. Blockade...
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A case of unrecognized pregnancy during chemotherapy in non-small cell lung cancer patient

Park JY, Park JW, Lee DO, Park CW, Park JS, Jun JK, Syn HC

Most chemotherapeutic drugs are known to possess significant teratogenic effects. Although several agents have been proven to be safe for the fetus after organogenesis period, there is limited information on...
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Preconception infection and genetic counseling

Ryu KY, Hoh JK, Park MI

Congenital malformations are a common cause of illness, handicapping conditions, and death. Errors of morphogenesis leading to congenital anomalies have many recognized causes, including specific single-gene mutations, chromosome imbalances, and...
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A Case of Branchio-Otic Syndrome

Kim TY, Eom JW, Kwak HH, Heo KW

Branchio-oto-renal (BOR) syndrome is a clinically heterogeneous autosomal dominant form of syndromic hearing loss characterized by variable hearing impairment, malformations of the pinnae, the presence of branchial arch remnants, and...
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Expression and Cellular Localization of Psx Gene in Rat Placenta

Choi EH, Jung C, Nam KI, Lee SW, Bae CS, Kim BY, Park SS, Ahn KY

  • KMID: 1982474
  • Korean J Phys Anthropol.
  • 2011 Mar;24(1):51-56.
Homeobox genes seem to play critical roles in regulating morphogenesis, patterning, organogenesis, and differentiation. They have the conserved sequence that codes the DNA-binding domain called homeodomain. The expression and cellular...
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The Pancreatic Tissue Regeneration and Molecular Regulators

Hong SW, Lee S, Park IS

  • KMID: 2092945
  • Korean J Anat.
  • 2008 Dec;41(4):223-230.
Pancreas is a unique organ that produces and secretes digestive enzymes to alimentary tube and supplies endocrine hormones regulating metabolic homeostasis. In the postnatal stage, pancreatic tissue is maintained by...
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Immunohistochemical identification and quantitative analysis of cytoplasmic Cu/Zn superoxide dismutase in mouse organogenesis

Yon JM, Baek IJ, Lee SR, Kim MR, Lee BJ, Yun YW, Nam SY

Cytoplasmic Cu/Zn superoxide dismutase (SOD1) is an antioxidant enzyme that converts superoxide to hydrogen peroxide in cells. Its spatial distribution matches that of superoxide production, allowing it to protect cells...
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Prenatal ultrasonographic diagnosis of Fetus in Fetu at 2nd trimester: A case report

Shim IS, Lee SA, Park MH, Park EA, Kim YJ, Choe GJ, Ahn JJ, Kim JI, Chun SH

  • KMID: 2273121
  • Korean J Obstet Gynecol.
  • 2007 Apr;50(4):673-677.
Fetus in fetu is an very rare condition in which a vertebrate fetus is incorporated within its twin. Although a number of cases were reported at 3rd trimester of gestation...
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Pancreatic Exocrine and Endocrine Cell Differentiation during Pancreatic Regeneration

Lee S, Hong SW, Eom JH, Lim WC, Park IS

  • KMID: 2168083
  • Hanyang Med Rev.
  • 2007 Feb;27(1):49-59.
Pancreatic tissue is maintained by a simple proliferation of the preexisting cells in adulthood, whereas, they are dynamically derived from precursor/ stem cells from ductal epithelia during prenatal life. It...
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Intraductal Papillary Mucinous Neoplasm in a Patient with an Incomplete Pancreatic Divisum

Nam SM, Chung WC, Chin HM, Lee KM, Lee BI, Chang UI, Yang JM, Choi KY, Chung IS

  • KMID: 2415622
  • Korean J Gastrointest Endosc.
  • 2006 Sep;33(3):191-196.
Intraductal papillary mucinous neoplasms (IPMNs) are premalignant lesions that require a surgical resection. IPMN can cause abdominal pain or pancreatitis as a result of either mucin production or a papillary...
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A Case of Fetus in Fetu

Kim JY, Yang SH, Hong SY, Choo DH, Oh HK, Park YC, Chung HL, Kim WT

  • KMID: 2280573
  • Korean J Perinatol.
  • 2006 Jun;17(2):225-230.
Fetus in fetu is an extremely uncommon cause of abdominal mass in the neonate with an incidence of 1 in 500,000 births. This is thought to occur when a monozygotic,...
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A Case of Caudal Regression Syndrome Diagnosed by Prenatal Ultrasonography

Moon Y, Kim JH, Ahn OJ, Jeon SW, Hwang BC

  • KMID: 2272638
  • Korean J Obstet Gynecol.
  • 2005 Jul;48(7):1788-1792.
Caudal regression syndrome is rare malformative syndrome characterized by lower vertebral agenesis, accompanied by abnormalities of the pelvis, lower extremities and urogenital malformation. Although the cause is not clear, hyperglycemia...
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Fetal Organogenesis in a Pregestational Diabetic Mother Who has Taking an Oral Hypoglycemic Agent in Early Pregnancy

Lee CB, Kim SY

  • KMID: 2008181
  • J Korean Diabetes Assoc.
  • 2004 Dec;28(6):530-537.
BACKGROUND: Women with diabetes mellitus are not treated with oral hypoglycemic agents because of the concerns about teratogenicity and neonate complication. There is not enough information about the safety of...
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