Korean J Obstet Gynecol.  2011 Dec;54(12):807-811. 10.5468/KJOG.2011.54.12.807.

A case of unrecognized pregnancy during chemotherapy in non-small cell lung cancer patient

• Park JY
• Park JW
• Lee DO
• Park CW
• Park JS
• Jun JK
• Syn HC

• KMID: 1443947
• DOI: http://doi.org/10.5468/KJOG.2011.54.12.807

Abstract

Most chemotherapeutic drugs are known to possess significant teratogenic effects. Although several agents have been proven to be safe for the fetus after organogenesis period, there is limited information on their use during pregnancy and it is very difficult to establish researches on the effect to human. We report a very unique case of unrecognized pregnancy in lung cancer patient who had been treated with variable agents of chemotherapy. A 25-year-old woman (gravida 0) who had been diagnosed as non-small cell lung cancer 6 years ago and received multiple regimens of chemotherapy presented at full term pregnancy with unknown gestational period. Without knowledge of pregnancy, she received a palliative chemotherapy with Docetaxel during first and second trimesters. Vaginal delivery with induction of labor due to postterm pregnancy was performed after evaluation of her medical condition and fetal surveillance. A 2,450 g female newborn was delivered with no evidence of congenital malformations.

Keyword

Pregnancy; Lung neoplasmas; Antineoplastic combined chemotherapy protocols

MeSH Terms

Adult
Antineoplastic Combined Chemotherapy Protocols
Carcinoma, Non-Small-Cell Lung
Female
Fetus
Humans
Infant, Newborn
Lung Neoplasms
Organogenesis
Pregnancy
Pregnancy Trimester, Second
Taxoids
Taxoids

Figure

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  Fig. 1 (A) Probable metastatic nodule in right post central gyrus and (B) another metastatic nodule left medial temporal lobe were found in brain magnetic resonance imaging taken in October, 2010.

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  Fig. 2 Chest radiograph posterior anterior view shows multiple nodular lesions in both sides of lung before induction of labor.

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