- Molecular Physiology of Renal Organic Anion Transporters
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Kwon TH
- KMID: 2253307
- Korean J Nephrol.
- 2008 Mar;27(2):171-174.
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- Introduction of Organic Anion Transporters (SLC22A) and a Regulatory Mechanism by Caveolins
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Lee WK, Jung SM, Kwak JO, Cha SH
- KMID: 2052264
- Electrolyte Blood Press.
- 2006 Mar;4(1):8-17.
- doi: 10.5049/EBP.2006.4.1.8
The kidney is an important organ for controlling the volume of body fluids, electrolytic balance and excretion/reabsorption of endogenous and exogenous compounds. Among these renal functions, excretion/reabsorption of endogenous and... -
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- Effects of Increased Uric Acid Intake on the Abundance of Urate-anion exchanger and Organic Anion Transporter Proteins in the Rat Kidney
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Kim S, Lee CH, Kang CM, Kim GH
- KMID: 2052287
- Electrolyte Blood Press.
- 2007 Dec;5(2):62-67.
- doi: 10.5049/EBP.2007.5.2.62
Renal handling of uric acid mainly occurs in the proximal tubule, and bidirectional transport of urate may involve apical absorption via the urate-anion exchanger (URAT1) and basolateral uptake via organic... -
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- Decreased Expression of Na+/K+-ATPase, NHE3, NBC1, AQP1 and OAT in Gentamicin-induced Nephropathy
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Bae WK, Lee JU, Park JW, Bae EH, Ma SK, Kim SH, Kim SW
- KMID: 2285360
- Korean J Physiol Pharmacol.
- 2008 Dec;12(6):331-336.
- doi: 10.4196/kjpp.2008.12.6.331
The present study was aimed to determine whether there is an altered regulation of tubular transporters in gentamicin-induced nephropathy. Sprague-Dawley male rats (200~250 g) were subcutaneously injected with gentamicin (100... -
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- Effects of Losartan Administration on Uric acid Transporters in Rat Kidney
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Kim S, Lee CH, Kang CM, Kim GH
- KMID: 2012309
- J Korean Soc Hypertens.
- 2010 Jun;16(2):19-27.
BACKGROUND: Losartan, an angiotensin II receptor blockade, has been reported to decrease the serum uric acid level through its uricosuric action. However, the mechanism by which losartan affects renal handling... -
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- Bosentan and Rifampin Interactions Modulate Influx Transporter and Cytochrome P450 Expression and Activities in Primary Human Hepatocytes
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Han KM, Ahn SY, Seo H, Yun J, Cha HJ, Shin JS, Kim YH, Kim H, Park HK, Lee YM
- KMID: 2378807
- Biomol Ther.
- 2017 May;25(3):288-295.
- doi: 10.4062/biomolther.2016.153
The incidence of polypharmacy-which can result in drug-drug interactions-has increased in recent years. Drug-metabolizing enzymes and drug transporters are important polypharmacy modulators. In this study, the effects of bosentan and... -
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- Identification of a novel murine organic anion transporter like protein 1 (OATLP1) expressed in the kidney
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Jung SM, Lee WK, Kwak JO, Jung SY, Park J, Kim WY, Kim J, Cha SH
- KMID: 1098082
- Exp Mol Med.
- 2006 Oct;38(5):485-493.
The organic anion transporters (OATs) are expressed in various tissues, primarily in the kidney and liver, but they are also expressed in the placenta, small intestine, and the choroid plexus,... -
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- Association of rOAT1 with Caveolin-1 in Rat Kidney
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Cha SH, Won YJ, Hwang JS, Suh CK
- KMID: 2253308
- Korean J Nephrol.
- 2008 Mar;27(2):175-185.
PURPOSE: A family of organic anion transporters (OAT) has been identified, and several isoforms have been reported. The regulatory mechanisms of OATs functions, however, still remain to be elucidated. The... -
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- Co-localization and interaction of human organic anion transporter 4 with caveolin-1 in primary cultured human placental trophoblasts
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Lee WK, Choi JK, Cha SH
- KMID: 1104804
- Exp Mol Med.
- 2008 Oct;40(5):505-513.
- doi: 10.3858/emm.2008.40.5.505
The human organic anion transporter 4 (hOAT4) has been identified as the fourth isoform of OAT family. hOAT4 contributes to move several negatively charged organic compounds between cells and their... -
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- Polymorphisms of SLC22A9 (hOAT7) in Korean Females with Osteoporosis
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Ahn SK, Suh CK, Cha SH
- KMID: 2285574
- Korean J Physiol Pharmacol.
- 2015 Jul;19(4):319-325.
- doi: 10.4196/kjpp.2015.19.4.319
Among solute carrier proteins, the organic anion transporters (OATs) play an important role for the elimination or reabsorption of endogenous and exogenous negatively charged anionic compounds. Among OATs, SLC22A9 (hOAT7)... -
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- Novel Compound Heterozygote Mutations of the SLC25A13 Gene in an Infant with Neonatal-onset Type II Citrullinemia Detected by Newborn Mass Screening
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Lim HS, Kim H, Kim SS, Kim GH, Yoo HW, Shin YL
- KMID: 2099215
- J Korean Soc Neonatol.
- 2011 Nov;18(2):370-373.
- doi: 10.5385/jksn.2011.18.2.370
Citrin deficiency caused by the SLC25A13 gene mutations is associated with both neonatal-onset type II citrullinemia (CTLN2), also known as neonatal intrahepatic cholestasis caused by citrin deficiency and adult-onset CTLN2.... -
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- Consensus Report of the 4th International Forum for Gadolinium-Ethoxybenzyl-Diethylenetriamine Pentaacetic Acid Magnetic Resonance Imaging
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Lee JM, Zech CJ, Bolondi L, Jonas E, Kim MJ, Matsui O, Merkle EM, Sakamoto M, Choi BI
- KMID: 1783206
- Korean J Radiol.
- 2011 Aug;12(4):403-415.
- doi: 10.3348/kjr.2011.12.4.403
This paper reports on issues relating to the optimal use of gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid magnetic resonance imaging (Gd-EOB-DTPA MR imaging) together with the generation of consensus statements from a working... -
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- Identification of the Mutations in the Prostaglandin Transporter Gene, SLCO2A1 and Clinical Characterization in Korean Patients with Pachydermoperiostosis
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Lee S, Park SY, Kwon HJ, Lee CH, Kim OH, Rhee Y
- KMID: 2373671
- J Korean Med Sci.
- 2016 May;31(5):735-742.
- doi: 10.3346/jkms.2016.31.5.735
Pachydermoperiostosis (PDP), or primary hypertrophic osteoarthropathy, is a rare genetic disease affecting both skin and bones. Both autosomal dominant with incomplete penetrance and recessive inheritance of PDP have been previously... -
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- From DCPD to NTCP: The long journey towards identifying a functional hepatitis B virus receptor
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Li J, Tong S
- KMID: 2351018
- Clin Mol Hepatol.
- 2015 Sep;21(3):193-199.
- doi: 10.3350/cmh.2015.21.3.193
Hepatitis B virus (HBV) is the prototype of hepatotropic DNA viruses (hepadnaviruses) infecting a wide range of human and non-human hosts. Previous studies with duck hepatitis B virus (DHBV) identified... -
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- New perspectives of biomarkers for the management of chronic hepatitis B
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Lin CL, Kao JH
- KMID: 2373145
- Clin Mol Hepatol.
- 2016 Dec;22(4):423-431.
- doi: 10.3350/cmh.2016.0069
With recent advances in molecular and genomic investigations, the impact of hepatitis B viral and host factors on the progression of chronic HBV infection has been explored. For viral factors,... -
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- A Case of Exercise-induced Acute Renal Failure with G774A Mutation in SCL22A12 Causing Renal Hypouricemia
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Kim YH, Cho JT
- KMID: 1779401
- J Korean Med Sci.
- 2011 Sep;26(9):1238-1240.
- doi: 10.3346/jkms.2011.26.9.1238
Acute renal failure with severe loin pain which develops after anaerobic exercise is rare. One of predisposing factors of exercise-induced acute renal failure is renal hypouricemia. Idiopathic renal hypouricemia is... -
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- Neonatal Intrahepatic Cholestasis Caused by Citrin Deficiency in Korean Infants
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Ko JS, Song JH, Park SS, Seo JK
- KMID: 1785752
- J Korean Med Sci.
- 2007 Dec;22(6):952-956.
- doi: 10.3346/jkms.2007.22.6.952
Citrin is a liver-type mitochondrial aspartate-glutamate carrier encoded by the SLC25A13 gene, and its deficiency causes adult-onset type II citrullinemia and neonatal intrahepatic cholestasis caused by citrin deficiency (NICCD). Here,... -
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