- Effect of trypsin on hepatocyte membrane deformity induced by phalloidine
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Ahn BM, Yang JM, Kim JK, Han NI, Suh JM, Shim KS, Lee YS, Chung KW, Kim HM, Oh GT
- KMID: 1696443
- Korean J Gastroenterol.
- 1993 Apr;25(2):330-336.
No abstract available. -
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- The Role of Macrophage Lipophagy in Reverse Cholesterol Transport
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Jeong SJ, Lee MN, Oh GT
- KMID: 2413285
- Endocrinol Metab.
- 2017 Mar;32(1):41-46.
- doi: 10.3803/EnM.2017.32.1.41
Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step... -
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- The Roles of CD137 Signaling in Atherosclerosis
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Jung IH, Oh GT
- KMID: 2355448
- Korean Circ J.
- 2016 Nov;46(6):753-761.
- doi: 10.4070/kcj.2016.46.6.753
The tumor necrosis factor receptor superfamily (TNFRSF), which includes CD40, LIGHT, and OX40, plays important roles in the initiation and progression of cardiovascular diseases, involving atherosclerosis. CD137, a member of... -
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- The Role of Autophagy in the Pathogenesis of Atherosclerosis
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Hur SK, Park SH, Oh GT
- KMID: 2328833
- J Lipid Atheroscler.
- 2016 Jun;5(1):1-10.
- doi: 10.12997/jla.2016.5.1.1
Autophagy is a life-sustaining process by which cytoplasmic constituents are segregated in double-lipid bilayer membrane vesicles and undergo degradation into lysosomes. In recent studies, the basal autophagy is an indispensable... -
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- Unbalanced Redox With Autophagy in Cardiovascular Disease
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Jeong SJ, Oh GT
- KMID: 2542818
- J Lipid Atheroscler.
- 2023 May;12(2):132-151.
- doi: 10.12997/jla.2023.12.2.132
Precise redox balance is essential for the optimum health and physiological function of the human body. Furthermore, an unbalanced redox state is widely believed to be part of numerous diseases,... -
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- Peroxisomal Fitness: A Potential Protective Mechanism of Fenofibrate against High Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice
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Jiang S, Uddin MJ, Yu X, Piao L, Dorotea D, Oh GT, Ha H
- KMID: 2536142
- Diabetes Metab J.
- 2022 Nov;46(6):829-842.
- doi: 10.4093/dmj.2021.0274
Background: Non-alcoholic fatty liver disease (NAFLD) has been increasing in association with the epidemic of obesity and diabetes. Peroxisomes are single membrane-enclosed organelles that play a role in the metabolism... -
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- Dopamine Transporter Genotype Influences the Attention Deficit in Korean Boys with ADHD
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Oh KS, Shin DW, Oh GT, Noh KS
- KMID: 2428344
- Yonsei Med J.
- 2003 Oct;44(5):787-792.
Attention appears to be inheritable, stable and influenced by genetic factors. The use of the Continuous Performance Test (CPT), as an endophenotypic measure, is valuable for genetic studies because it... -
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- Vimentin Deficiency Prevents High-Fat Diet-Induced Obesity and Insulin Resistance in Mice
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Kim S, Kim I, Cho W, Oh GT, Park YM
- KMID: 2514078
- Diabetes Metab J.
- 2021 Jan;45(1):97-108.
- doi: 10.4093/dmj.2019.0198
Background Obesity and type 2 diabetes mellitus are world-wide health problems, and lack of understanding of their linking mechanism is one reason for limited treatment options. We determined if genetic deletion... -
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- Inhibitory effects of tilianin on the expression of inducible nitric oxide synthase in low density lipoprotein receptor deficiency mice
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Nam KH, Choi JH, Seo YJ, Lee YM, Won YS, Lee MR, Lee MN, Park JG, Kim YM, Kim HC, Lee CH, Lee HK, Oh SR, Oh GT
- KMID: 1110129
- Exp Mol Med.
- 2006 Aug;38(4):445-452.
We investigated the effect of tilianin upon inducible nitric oxide synthesis in the plasma of low-density lipoprotein receptor knock-out (Ldlr-/-) mice fed with high cholesterol diet and in primary peritoneal... -
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- Effects of Fluoxetine on Membrane Potential and Ionic Currents in RINm5F Insulinoma Cells
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Park KC, Oh GT, Cha SK, Lee KI, Park KS, Jeong SW, Kong ID, Lee JW
- KMID: 2286921
- Korean J Psychopharmacol.
- 2001 Sep;12(3):233-241.
OBJECTIVE: The purpose of this study was to investigate the effects of fluoxetine (Prozac) on membrane potential and ionic currents in RINm5F insulinoma cells. METHODS: Membrane potential and ionic currents... -
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- Induction of hepatic inducible nitric oxide synthase by cholesterol in vivo and in vitro
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Kim JW, Kang KW, Oh GT, Song J, Kim ND, Pak YK
- KMID: 1081463
- Exp Mol Med.
- 2002 May;34(2):137-144.
Cholesterol-rich diet impairs endothelial NO synthase (eNOS) and enhances inducible NOS (iNOS) expression. In this study, we investigated effects of cholesterol on iNOS expression in high-fat-fed rat models, HepG2 and... -
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- Effects of prostaglandins on ethanol damage in primary cultured rat hepatocytes
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Yang JM, Choi SW, Kim SS, Sun HS, Park DH, Han SB, Oh GT, Kim WM
- KMID: 759062
- Korean J Intern Med.
- 1998 Feb;13(1):1-9.
OBJECTIVES: Several reports demonstrated that ethanol administration impairs the DNA synthesis in rat hepatocytes. Also, it has been demonstrated that prostaglandin (PG) helps prevent membrane damage by hepatotoxic chemicals. In ... -
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- Overexpression of cyclin D1 and cyclin E in 1,2-dimethylhydrazine dihydrochloride-induced rat colon carcinogenesis
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Hur K, Kim JR, Yoon BI, Lee JK, Choi JH, Oh GT, Kim DY
- KMID: 1094650
- J Vet Sci.
- 2000 Dec;1(2):121-126.
Deregulation of G1 cyclins has been reported in several human and rodent tumors including colon cancer. To investigate the expression pattern of G1 cyclins in 1,2- dimethyl-hydrazine dihydrochloride (DMH)-induced rat... -
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- The Effect of Glucose Control on DNA and Collagen Synthesis of Cultured Fibroblasts of Chronic Diabetic Wounds
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Kim JD, Kang NH, Kwon H, Lim P, Oh GT
- KMID: 2119711
- J Korean Soc Plast Reconstr Surg.
- 2001 Jan;28(1):26-31.
Diabetes is accompanied by delayed wound healing and insufficient granulation tissue formation, possibly because of a defect in fibroblast function. Maintaining glucose level at acceptable low level is considered to... -
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- Phenotype of peroxisome proliferator-activated receptor-alpha(PPARalpha)deficient mice on mixed background fed high fat diet
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Kim BH, Won YS, Kim EY, Yoon M, Nam KT, Oh GT, Kim DY
- KMID: 1089604
- J Vet Sci.
- 2003 Dec;4(3):239-244.
Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha(PPARalpha) on obesity. Previous reports demonstrated that PPARalpha is a critical modulator of lipid homeostasis, but the overt, obese phenotypic... -
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- Ginkgo biloba extract (GbE) enhances the anti-atherogenic effect of cilostazol by inhibiting ROS generation
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Jung IH, Lee YH, Yoo JY, Jeong SJ, Sonn SK, Park JG, Ryu KH, Lee BY, Han HY, Lee SY, Kim DY, Lee H, Oh GT
- KMID: 1383792
- Exp Mol Med.
- 2012 May;44(5):311-318.
In this study, the synergistic effect of 6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2(1H)-quinolinone (cilostazol) and Ginkgo biloba extract (GbE) was examined in apolipoprotein E (ApoE) null mice. Co-treatment with GbE and cilostazol synergistically decreased... -
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- Fenofibrate regulates obesity and lipid metabolism with sexual dimorphism
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Yoon MC, Jeong SH, Nicol CJ, Lee HH, Han MY, Kim JJ, Seo YJ, Ryu CY, Oh GT
- KMID: 1121103
- Exp Mol Med.
- 2002 Dec;34(6):481-488.
To determine whether the PPARalpha agonist fenofibrate regulates obesity and lipid metabolism with sexual dimorphism, we examined the effects of fenofibrate on body weight, white adipose tissue (WAT) mass,... -
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- KR-31543 reduces the production of proinflammatory molecules in human endothelial cells and monocytes and attenuates atherosclerosis in mouse model
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Choi JH, Yoo JY, Kim SO, Yoo SE, Oh GT
- KMID: 1402317
- Exp Mol Med.
- 2012 Dec;44(12):733-739.
KR-31543, (2S, 3R, 4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro-2-dimethyoxymethyl-3-hydroxy-2-methyl-2H-1-benz opyran is a new neuroprotective agent for ischemia-reperfusion damage. It has also been reported that KR-31543 has protective effects on lipid peroxidation and H2O2-induced reactive... -
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- 5-(4-Hydroxy-2,3,5-trimethylbenzylidene) thiazolidine-2,4-dione attenuates atherosclerosis possibly by reducing monocyte recruitment to the lesion
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Choi JH, Park JG, Jeon HJ, Kim MS, Lee MR, Lee MN, Sonn S, Kim JH, Lee MH, Choi MS, Park YB, Kwon OS, Jeong TS, Lee WS, Shim HB, Shin DH, Oh GT
- KMID: 1022122
- Exp Mol Med.
- 2011 Aug;43(8):471-478.
- doi: 10.3858/emm.2011.43.8.053
A variety of benzylidenethiazole analogs have been demonstrated to inhibit 5-lipoxygenase (5-LOX). Here we report the anti-atherogenic potential of 5-(4-hydroxy-2,3,5-trimethylbenzylidene) thiazolidin-2,4-dione (HMB-TZD), a benzylidenethiazole analog, and its potential mechanism of... -
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