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Spinal Nitric Oxide Synthase Type II Increases Neurosteroid-metabolizing Cytochrome P450c17 Expression in a Rodent Model of Neuropathic Pain

Choi SR, Beitz AJ, Lee JH

We have previously demonstrated that the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces functional potentiation of N-methyl-D-aspartate (NMDA) receptors via increases in phosphorylation of NMDA receptor GluN1 subunit (pGluN1). However, the modulatory...
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Inhibitory Effect of a Sesquiterpene from Artemisia iwayomogi on Expression of Inducible Nitric Oxide Synthase by Suppression of I-κBα Degradation in LPS-stimulated RAW 264.7 Cells

Kim NY, Koh HJ, Li H, Lee HJ, Ryu JH

A sesquiterpene was purified from Artemisia iwayomogi methanolic extract during the course of searching anti-inflammatory principle from medicinal plants. A sesquiterpene identified as armefolin inhibited the production of nitric oxide...
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Inducible Nitric Oxide Synthase (iNOS) Expression in the Hypoxic Injury to Pancreatic Beta (MIN6) Cells

Ko SH, Kim SB, Ryu KR, Kim JW, Ahn YB, Moon SD, Kim SR, Lee JM, Kwon HS, Yoon KH, Song KH

BACKGROUND: Islet transplantation is an alternative potential strategy to cure type 1 diabetes mellitus. However, two or more donors are usually needed for one recipient because a substantial part of...
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The Effect of Hypothermia on Lung Inducible Nitric Oxide Synthase Gene Expression in Intestinal Ischemia-Reperfusion Injury

Kim K, Lee JH, Suh GJ, Youn YK, Kang YJ, Kim MA, Cho SK, Shin HK

  • KMID: 2096952
  • J Korean Soc Traumatol.
  • 2006 Jun;19(1):14-20.
PURPOSE: Although hypothermia has been used in many clinical situations, such as post cardiopulmonary resuscitation, stroke, traumatic brain injury, septic shock, and hemorrhagic shock, the mechanism by which it works...
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Nitric oxide production and inducible nitric oxide synthase expression induced by Porphyromonas gingivalis lipopolysaccharide

Paek EY, Choi EY, Choi JI, Lee JY, Kim SJ

No abstract available.
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Correlation Between Neuronal Apoptosis and Expression of Inducible Nitric Oxide Synthase after Transient Focal Cerebral Ischemia

Yi BY, Hwang SK, Kang KS, Quan HH, Lee YM, Kim JW, Kwak EK, Park JY, Sohn YK

  • KMID: 2277690
  • Korean J Pathol.
  • 2004 Dec;38(6):364-371.
BACKGROUND: Neuronal death in acute-phase cerebral ischemic injury is caused by necrosis. However, neuronal injury after reperfusion can be associated with apoptosis. METHODS: We used Sprague-Dawley rats whose brains were...
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The Effect of Sevoflurane and Propofol on Expression of Inducible Nitric Oxide Synthase in Endotoxemic Rats

Kim CH, Park JH, Baek SH, Baik SW

  • KMID: 2228517
  • Korean J Crit Care Med.
  • 2004 Dec;19(2):106-114.
BACKGROUND: It is a well-known phenomenon that alveolar and peritoneal macrophages exposed to bacterial lipopolysaccharide (LPS) induce a large output of nitric oxide (NO) and an inducible nitric oxide synthase...
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Inhibitory Effect of Inducible Nitric Oxide Synthase Gene Transfer on Intimal Hyperplasia and Fibronectin Expression Induced by Carotid Artery Denudation

Kye BH, Hong SY, Yang KH, Park SC, Park JS

  • KMID: 1941030
  • J Korean Soc Vasc Surg.
  • 2004 Dec;20(2):192-199.
PURPOSE: Intimal hyperplasia is a pathologic condition that is commonly observed with the atherosclerotic change of blood vessels; this condition is usually observed after arterial operation and interventions such as...
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Inhibition of Inducible Nitric Oxide Synthase Expression by YS 49, a Synthetic Isoquinoline Alkaloid, in ROS 17/2.8 Cells Activated with TNF-alpha, IFN-gamma and LPS

Kang YJ, Kang SY, Lee YS, Park MK, Kim HJ, Seo HG, Lee JH, Yun-Choi H, Chang KC

  • KMID: 1611431
  • Korean J Physiol Pharmacol.
  • 2004 Oct;8(5):273-280.
Nitric oxide (NO) has been suggested to act as a mediator of cytokine-induced effects of turn over of bone. Activation of the inducible nitric oxide synthase (iNOS) by inflammation has...
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Expression of Tumor Necrosis Factor-alpha, Interleukin-1beta and Inducible Nitric Oxide Synthase after Stereotaxic Injection of Lipopolysaccharide in Rat Hippocampus

Oh HK, Kang KS, Kim JY, Kwak EK, Kim JW, Park JY, Sohn YK

  • KMID: 2275496
  • Korean J Pathol.
  • 2004 Jun;38(3):157-164.
BACKGROUND: Brain inducible nitric oxide synthase (iNOS) might be detectable in several pathologic conditions, and it is thought to play an important role in their pathophysiology. Tumor necrosis factor (TNF)-alpha...
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Expression of Inducible Nitric Oxide Synthase (iNOS, NOS2) in Osteosarcoma Correlates with Prognosis

Jeong J, Kim HS, Kang YK, Kim HS, Lee SH

  • KMID: 2399067
  • J Korean Orthop Assoc.
  • 2003 Oct;38(6):641-645.
PURPOSE: This study was performed to investigate the expression pattern of inducible nitric oxide synthase (iNOS) in osteosarcoma and to determine whether its expression correlates with metastatic potential and prognosis....
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Effect of Inducible Nitric Oxide Synthase Inhibitor on Apoptosis in Hypoxic-Ischemic Injury of the Neonatal Rat Brain: 1H Magnetic Resonance Spectroscopy Study

Hwang HS, Bang JY, Park PH

BACKGROUND: Inducible nitric oxide synthase (iNOS) is expressed during the late stage of ischemia and may play an important role in the delayed progression of ischemic brain injury. This study...
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Inducible Nitric Oxide Synthase (iNOS) is Increased in Diabetic Rat Glomeruli: Role of Angiotensin II (AII)

Choi KH, Noh H, Kim BS, Kang SW, Han DS, Lee HY

  • KMID: 1610172
  • Korean J Nephrol.
  • 2003 Jul;22(4):366-373.
BACKGROUND: This study was designed to examine whether iNOS pathway is pathologically altered in experimental diabetic nephropathy and whether therapy with ACE inhibitor (imidapril: I) or angiotensin II type 1...
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Expression of Cyclooxygenase-2 and Inducible Nitric Oxide Synthase in Colorectal Cancer

Yang KH, Bae BN, Kim JY, Kim KH, Han SH, Kim HJ, Kim YD, Kim HY, Kim SJ

  • KMID: 2025800
  • J Korean Soc Coloproctol.
  • 2003 Jun;19(3):144-150.
PURPOSE: Recently, it has been recognized that both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) produce important endogeneous factors of human tumor progression. The aims of this study is...
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Hemodynamic Change and Hypoxic Inducible Factor-1alpha and Inducible Nitric Oxide Synthase Expression of Ipsilateral Kidney during Acute Stage of Ureteropelvic Junction Obstruction in Adult Rat

Lee SD, Lee CH, Choi EH

  • KMID: 2293340
  • Korean J Urol.
  • 2003 May;44(5):481-489.
Purpose: This study aimed to evaluate the expression of inducible nitric oxide synthase (iNOS) and hypoxic inducible factor-1alpha (HIF-1alpha) and the hemodynamic changes in the renal medulla and cortex, during...
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Expression of Inducible Nitric Oxide Synthase (iNOS) in the Epithelial Cells of the Distended Bile Duct by the Bile Ductal Ligation

Park SS, Jin GB, Park JW, Jang LC, Sung RH, Choi JW

  • KMID: 2004555
  • J Korean Surg Soc.
  • 2003 May;64(5):365-371.
PURPOSE: Recent studies in an obstructive jaundice rat model showed that the bile duct epithelium is also very important in the bile duct dilatation besides the increased luminal pressure. This...
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The Role of Inducible Nitric Oxide Synthase in the Development of Nasal Hyper-responsiveness of the Rhinosinusitis Rat Model

Kim JP, Jeon SY, Ahn SK, Hwang WH, Sung BG, Kim EA

  • KMID: 2275965
  • Korean J Otolaryngol-Head Neck Surg.
  • 2003 Jan;46(1):35-41.
BACKGROUND AND OBJECTIVES: Hyper-responsiveness to nonspecific stimuli is a characteristic finding of all allergic diseases. It is probably due to eosinophil infiltration, release of cytotoxic proteins, and epithelial damage in...
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Role of Inducible Nitric Oxide Synthase as a Mediator of Renal Ischemia/Reperfusion Injury in the Rat

Moon KH, Cho CK, Jung HC, Park TC, Choi HC, Kim YJ, Choi TS

  • KMID: 2292527
  • Korean J Urol.
  • 2002 Dec;43(12):1070-1077.
PURPOSE: This study was undertaken to elucidate if nitric oxide (NO), produced by inducible nitric oxide synthase (iNOS) following renal ischemia/reperfusion (I/R), contributes to renal injury in rats, and if...
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Expression of Inducible Nitric Oxide Synthase and Nitric Oxide Mediated Apoptosis in Neuronal PC12 Cells after Lipopolysaccharide/Tumor Necrosis Factor-/Interferon- Treatment

Kim J, Kim J, Kang K, Kwak E, Park J, Park T, Sohn Y

  • KMID: 1725913
  • Korean J Pathol.
  • 2002 Aug;36(4):249-256.
BACKGROUND: Inducible nitric oxide synthase (iNOS) has been detected in a number of pathologic conditions in the central nervous system. This study was investigated the patterns of iNOS expression in...
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Inhibitory Effects of Paeonia Suffruticosa on the Expression of Inducible Nitric Oxide Synthase Gene in RAW264.7 Macrophages

Son SY, Sul CK, Onyango I

  • KMID: 2292466
  • Korean J Urol.
  • 2002 Jun;43(6):480-485.
PURPOSE: The aim of the present study was to examine the effect of the root cortex of Paeonia suffruticosa, an anti-inflammatory folk medicine, on nitric oxide (NO) synthesis and the...
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