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Nitric Oxide in the Kidney: Its Physiological Role and Pathophysiological Implications

Lee JU

Nitric oxide has been implicated in many physiologic processes that influence both acute and long-term control of kidney function. Its net effect in the kidney is to promote natriuresis and...
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Influence of Nitric Oxide Donor on the Regulation of ATP-sensitive K+ Channel Activity in Cardiac Myocytes

Ju JM, Shin DH, Lee WS, Park HW, Cho JG, Kim JH

  • KMID: 2116759
  • Chonnam Med J.
  • 2002 Jun;38(2):135-145.
It was investigated that effects of nitric oxide donors on the ATP-sensitive K+ channel (KATP channel) in isolated mouse ventricular cardiac myocytes using patch clamp techniques. In perforated whole-cell patches,...
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Modulation of Cytotoxicity by Nitric Oxide Donors during Treatment of Glioma with Anticancer Drugs

Park JJ, Kang JS, Lee HS, Lee JS, Lee YH, Youm JY

  • KMID: 1882179
  • J Korean Neurosurg Soc.
  • 2005 Nov;38(5):366-374.
OBJECTIVE: Nitric oxide(NO) is implicated in a wide range of biological processes in tumors and is produced in glioma. To investigate the role of NO and its interaction with the...
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Medical and Endoscopic Management of Achalasia

Han JP, Hong SJ

Achalasia is a rare primary esophageal motility disorder. Because its etiology is uncertain, treatment is focused on palliation of symptoms or for decreasing lower esophageal sphincter pressure. Treatment options include...
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Effect of Intrathecal Administration of Nitroglycerine in the Endothelin-1 Induced Rabbit Vasospasm Model

Shin YS, Kyu SH, Lee KS, Lee KC

  • KMID: 2067597
  • J Korean Neurosurg Soc.
  • 1999 Aug;28(8):1106-1114.
OBJECTIVE: Nitric oxide and endothelin-1 are two endothelium derived relaxing and constricting factors probably involved in the pathogenesis of cerebral vasospasm after subarachnoid hemorrhage. The aim of this study is...
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Effect of Nitric Oxide on the Proliferation of Cultured Porcine Trabecular Meshwork Cells

Kim JW, Heo H, Lee HW

To investigate the effect of nitric oxide (NO) on the proliferation of trabecular meshwork (TM) cells, primarily cultured porcine TM cells were exposed to NO donor (SNAP, -nitroso-N-acetyl-D, L-penicillamine) with...
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The Role of Nitric Oxide in Ocular Surface Cells

Kim JC, Park GS, Kim JK, Kim YM

The role of nitric oxide (NO) in the ocular surface remains unknown. We investigated the conditions leading to an increase of NO generation in tear and the main sources of...
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Effect of Nitric Oxide on the Expression of Matrix Metalloproteinase and Its Association with Migration of Cultured Trabecular Meshwork Cells

Kim JW

PURPOSE: To determine the effect of exogenous nitric oxide (NO) on the migration of trabecular meshwork (TM) cells and its association with expression of matrix metalloproteinases (MMPs). METHODS: Primary human TM...
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Effect of Nitric Oxide on the Cryopreservation of Platelets

Lee JH, Kim JT, Cho YG

BACKGROUND: To determine whether nitric oxide (NO) could inhibit activation of platelets stored in a cold or frozen state, we measured platelet P-selectin expression and platelet-bound fibrinogen in platelet-rich...
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New classes of glaucoma medical treatment

Choi JA

Glaucoma is a progressive degenerative disease of the optic nerve head, characterized by a specific pattern of axonal loss and visual field deterioration. This review aims at introducing the different...
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Light-controlled relaxation of the rat penile corpus cavernosum using NOBL-1, a novel nitric oxide releaser

Hotta Y, Ieda N, Fukamoto A, Kataoka T, Kawade Y, Maeda Y, Nakagawa H, Kimura K

PURPOSE: To investigate whether relaxation of the rat penile corpus cavernosum could be controlled with NOBL-1, a novel, light-controllable nitric oxide (NO) releaser. MATERIALS AND METHODS: Fifteen-week-old male Wistar-ST rats were...
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Differentially Expressed Proteins in Nitric Oxide-Stimulated NIH/3T3 Fibroblasts: Implications for Inhibiting Cancer Development

Shim DH, Lim JW, Kim H

PURPOSE: Recent evidence shows that nitric oxide (NO) may exhibit both pro-cancer and anti-cancer activities. The present study aimed to determine the differentially expressed proteins in NO-treated NIH/3T3 fibroblasts in...
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Influence of nitric oxide on in vitro growth, survival, steroidogenesis, and apoptosis of follicle stimulating hormone stimulated buffalo (Bubalus bubalis) preantral follicles

Dubey PK, Tripathi V, Singh RP, Sharma GT

Effect of sodium nitroprusside (SNP), a nitric oxide (NO) donor, on in vitro survival, growth, steroidogenesis, and apoptosis of buffalo preantral follicles (PFs) was investigated. PFs (200~250 microm) were isolated...
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Protective Effect of Heat Shock Protein 70 Against Oxidative Stresses in Human Corneal Fibroblasts

Kim YS, Han JA, Cheong TB, Ryu JC, Kim JC

We evaluated DNA protection effect of heat shock protein (HSP) against cytotoxic effects of exogenous nitric oxide (NO) and reactive oxygen intermediate (ROI). Cultured human corneal fibroblasts were divided into...
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