- Organotypic slice culture of the hypothalamic paraventricular nucleus of rat
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Cho ES, Lee SY, Park JY, Hong SG, Ryu PD
- KMID: 1104231
- J Vet Sci.
- 2007 Mar;8(1):15-20.
- doi: 10.4142/jvs.2007.8.1.15
Organotypic slice cultures have been developed as an alternative to acute brain slices because the neuronal viability and synaptic connectivity in these cultures can be preserved well for a prolonged... -
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- In vitro neuronal and osteogenic differentiation of mesenchymal stem cells from human umbilical cord blood
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Park KS, Lee YS, Kang KS
- KMID: 1089481
- J Vet Sci.
- 2006 Dec;7(4):343-348.
- doi: 10.4142/jvs.2006.7.4.343
Mesenchymal stem cells (MSCs) have the capabilities for self-renewal and differentiation into cells with the phenotypes of bone, cartilage, neurons and fat cells. These features of MSCs have attracted the... -
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- Neuronal autophagy and neurodegenerative diseases
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Son JH, Shim JH, Kim KH, Ha JY, Han JY
- KMID: 1120127
- Exp Mol Med.
- 2012 Feb;44(2):89-98.
- doi: 10.3858/emm.2012.44.2.031
Autophagy is a dynamic cellular pathway involved in the turnover of proteins, protein complexes, and organelles through lysosomal degradation. The integrity of postmitotic neurons is heavily dependent on high basal... -
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- Bone morphogenetic protein 4 stimulates neuronal differentiation of neuronal stem cells through the ERK pathway
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Moon BS, Yoon JY, Kim MY, Lee SH, Choi T, Choi KY
- KMID: 1109434
- Exp Mol Med.
- 2009 Feb;41(2):116-125.
- doi: 10.3858/emm.2009.41.2.014
Bone morphogenic protein 4 (BMP4), a member of the TGF-beta superfamily, induced neural differentiation of neural stem cells (NSCs) grown in a medium containing basic fibroblast growth factor (bFGF). The... -
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- CDK5-dependent inhibitory phosphorylation of Drp1 during neuronal maturation
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Cho B, Cho HM, Kim HJ, Jeong J, Park SK, Hwang EM, Park JY, Kim WR, Kim H, Sun W
- KMID: 2155370
- Exp Mol Med.
- 2014 Jul;46(7):e105.
- doi: 10.1038/emm.2014.36
Mitochondrial functions are essential for the survival and function of neurons. Recently, it has been demonstrated that mitochondrial functions are highly associated with mitochondrial morphology, which is dynamically changed by... -
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- Adaptive Responses Induced by Low Dose Radiation in Dentate Gyrus of Rats
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Kang JO, Hong SE, Kim SK, Kim CJ, Lee TH, Chang HK, Shin MS, Kim H
- KMID: 1713127
- J Korean Med Sci.
- 2006 Dec;21(6):1103-1107.
- doi: 10.3346/jkms.2006.21.6.1103
The purpose of this study is to investigate the mechanism of alternative responses to low dose irradiation for neuronal cell proliferation in the dentate gyrus of rats. To determine the... -
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- Differentiation of Human Dental Pulp Stem Cells into Dopaminergic Neuron-like Cells in Vitro
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Chun SY, Soker S, Jang YJ, Kwon TG, Yoo ES
- KMID: 2360038
- J Korean Med Sci.
- 2016 Feb;31(2):171-177.
- doi: 10.3346/jkms.2016.31.2.171
We investigated the potential of human dental pulp stem cells (hDPSCs) to differentiate into dopaminergic neurons in vitro as an autologous stem cell source for Parkinson's disease treatment. The hDPSCs... -
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- The roles of glycosphingolipids in the proliferation and neural differentiation of mouse embryonic stem cells
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Jung JU, Ko K, Lee DH, Ko K, Chang KT, Choo YK
- KMID: 1099869
- Exp Mol Med.
- 2009 Dec;41(12):935-945.
- doi: 10.3858/emm.2009.41.12.099
Glycosphingolipids including gangliosides play important regulatory roles in cell proliferation and differentiation. UDP-glucose:ceramide glucosyltransferase (Ugcg) catalyze the initial step in glycosphingolipids biosynthesis pathway. In this study, Ugcg expression was reduced... -
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- Endothelin 1 protects HN33 cells from serum deprivation-induced neuronal apoptosis through Ca2+-PKCalpha-ERK pathway
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Park MH, Lee DH
- KMID: 1103592
- Exp Mol Med.
- 2008 Feb;40(1):92-97.
- doi: 10.3858/emm.2008.40.1.92
Endothelins (ETs), which were originally found to be potent vasoactive transmitters, were known to be implicated in nervous system, but the mode of mechanism remains unclear. ETs (ET-1, ET-2, and... -
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- Isolation of neural precursor cells from skeletal muscle tissues and their differentiation into neuron-like cells
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Park JS, Kim S, Han DK, Lee JY, Ghil SH
- KMID: 756071
- Exp Mol Med.
- 2007 Aug;39(4):483-490.
Skeletal muscle contains several precursor cells that generate muscle, bone, cartilage and blood cells. Although there are reports that skeletal muscle-derived cells can trans-differentiate into neural-lineage cells, methods for isolating... -
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- Neuronal loss in primary long-term cortical culture involves neurodegeneration-like cell death via calpain and p35 processing, but not developmental apoptosis or aging
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Kim MJ, Oh SJ, Park SH, Kang HJ, Won MH, Kang TC, Park JB, Kim JI, Kim J, Lee JY
- KMID: 1103677
- Exp Mol Med.
- 2007 Feb;39(1):14-26.
Primary neuronal culture is a powerful tool to study neuronal development, aging, and degeneration. However, cultured neurons show signs of cell death after 2 or 3 weeks. Although the mechanism... -
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- Neuroprotection signaling pathway of nerve growth factor and brain-derived neurotrophic factor against staurosporine induced apoptosis in hippocampal H19-7 cells
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Nguyen TL, Kim CK, Cho JH, Lee KH, Ahn JY
- KMID: 1104385
- Exp Mol Med.
- 2010 Aug;42(8):583-595.
- doi: 10.3858/emm.2010.42.8.060
Neurotrophins protect neurons against excitotoxicity; however the signaling mechanisms for this protection remain to be fully elucidated. Here we report that activation of the phosphatidyl inositol 3 kinase (PI3K)/Akt pathway... -
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- Dynamic changes of gangliosides expression during the differentiation of embryonic and mesenchymal stem cells into neural cells
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Kwak DH, Yu K, Kim SM, Lee DH, Kim SM, Jung JU, Seo JW, Kim N, Lee SK, Jung KY, You H, Kim HA, Choo YK
- KMID: 1115945
- Exp Mol Med.
- 2006 Dec;38(6):668-676.
Stem cells are used for the investigation of developmental processes at both cellular and organism levels and offer tremendous potentials for clinical applications as an unlimited source for transplantation. Gangliosides,... -
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- Migration of human neural stem cells toward an intracranial glioma
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Jeon JY, An JH, Kim SU, Park HG, Lee MA
- KMID: 1103591
- Exp Mol Med.
- 2008 Feb;40(1):84-91.
- doi: 10.3858/emm.2008.40.1.84
Many in vivo and in vitro studies have demonstrated the targeted migration of neural stem cells (NSC) to infiltrating brain tumors, including malignant glioma, highlighting a potential therapeutic approach. However,... -
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- CD99 type II is a determining factor for the differentiation of primitive neuroectodermal cells
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Lee EJ, Lee HG, Park SH, Choi EY, Park SH
- KMID: 1093617
- Exp Mol Med.
- 2003 Oct;35(5):438-447.
CD99 is a 32-kDa cell surface molecule present on thymocytes, peripheral T cells, many other hematopoietic stem cells and somatic cells were implicated in cell-cell adhesion and cell-activation phenomena. Two... -
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- Functional recovery and neural differentiation after transplantation of allogenic adipose-derived stem cells in a canine model of acute spinal cord injury
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Ryu HH, Lim JH, Byeon YE, Park JR, Seo MS, Lee YW, Kim WH, Kang KS, Kweon OK
- KMID: 1726898
- J Vet Sci.
- 2009 Dec;10(4):273-284.
- doi: 10.4142/jvs.2009.10.4.273
In this study, we evaluated if the implantation of allogenic adipose-derived stem cells (ASCs) improved neurological function in a canine spinal cord injury model. Eleven adult dogs were assigned to... -
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- Neuron-Like Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells
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Bae KS, Park JB, Kim HS, Kim DS, Park DJ, Kang SJ
- KMID: 1777011
- Yonsei Med J.
- 2011 May;52(3):401-412.
- doi: 10.3349/ymj.2011.52.3.401
PURPOSE: Mesenchymal stem cells (MSCs) are multipotent and give rise to distinctly differentiated cells from all three germ layers. Neuronal differentiation of MSC has great potential for cellular therapy. We... -
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- Induction of unfolded protein response during neuronal induction of rat bone marrow stromal cells and mouse embryonic stem cells
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Cho YM, Jang YS, Jang YM, Chung SM, Kim HS, Lee JH, Jeong SW, Kim IK, Kim JJ, Kim KS, Kwon OJ
- KMID: 756236
- Exp Mol Med.
- 2009 Jun;41(6):440-452.
- doi: 10.3858/emm.2009.41.6.049
When we treated rat bone marrow stromal cells (rBMSCs) with neuronal differentiation induction media, typical unfolded protein response (UPR) was observed. BIP/GRP78 protein expression was time-dependently increased, and three branches... -
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- Mass spectrometry based proteomic analysis of human stem cells: a brief review
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Choi MY, An YJ, Kim SH, Roh SH, Ju HK, Hong SS, Park JH, Cho KJ, Choi DW, Kwon SW
- KMID: 1091063
- Exp Mol Med.
- 2007 Dec;39(6):690-695.
Stem cells can give rise to various cell types and are capable of regenerating themselves over multiple cell divisions. Pluripotency and self-renewal potential of stem cells have drawn vast interest... -
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