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Clinical Implications of Social Communication Disorder

Shin SH

Social (pragmatic) communication disorder (SCD) is a new diagnosis included under communication disorders in the neurodevelopmental disorders section of Diagnostic and Statistical Manual of Mental Disorders-5. SCD is defined as...
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Multidisciplinary Approaches in Developing Guideline for Mediating Behavioral Problems in Children and Adolescents with Neurodevelopmental Disorders

Hong K, Song H, Oh M, Oh Y, Park S, Kim Y, Choi S

OBJECTIVES: To initiate and develop a treatment guideline in multidisciplinary approaches for related professions who are either working and/or living with children and adolescents with neurodevelopmental disorders who show behavioral...
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Somatic mutations in disorders with disrupted brain connectivity

Lee JH

Mutations occur during cell division in all somatic lineages. Because neurogenesis persists throughout human life, somatic mutations in the brain arise during development and accumulate with the aging process. The...
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Influence of clozapine on neurodevelopmental protein expression and behavioral patterns in animal model of psychiatric disorder induced by low-level of lead

Lee H, Lee M, Kim HK, Kim YO, Kwon JT, Kim HJ

Exposure to lead during pregnancy is a risk factor for the development of psychiatric disorders in the offspring. In this study, we investigated whether exposure to low levels of lead...
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Socioeconomic disparities and difficulties to access to healthcare services among Canadian children with neurodevelopmental disorders and disabilities

Raouafi S, Achiche S, Raison M

OBJECTIVES: The aims of this study were to identify the associations of levels of severity of neurodevelopmental disorders and disabilities (NDD/D) in children with their household socioeconomic status (SES) and...
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Fine Dust and Dementia: Is Ambient Air Pollution Associated with Cognitive Health?

Han SH

Air pollution is a growing global health concern estimated to contribute to as many as 4.2 million premature deaths worldwide per year. So it poses the greatest environmental risk to...
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Methylphenidate Induced Lip and Tongue Biting

Gokcen C, Karadag M, Aksoy I

Attention deficit hyperactivity disorder (ADHD) is a life-long neurodevelopmental disorder and treatment depends on pharmacotherapy because of its biological origin. Stimulant drugs are the most commonly used treatment for ADHD...
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The Relationship of Clinical Symptoms with Social Cognition in Children Diagnosed with Attention Deficit Hyperactivity Disorder, Specific Learning Disorder or Autism Spectrum Disorder

Şahin B, Karabekiroğlu K, Bozkurt A, Usta MB, Aydın M, Çobanoğlu C

OBJECTIVE: One of the areas of social cognition is Theory of Mind (ToM) is defined as the capacity to interpret, infer and explain mental states underlying the behavior of others....
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The Wnt Signaling Pathway and Related Therapeutic Drugs in Autism Spectrum Disorder

Bae SM, Hong JY

Autism spectrum disorder (ASD) is a series of neurodevelopmental disorder with a large genetic component. However, the pathogenic genes and molecular mechanisms of ASD have not been clearly defined. Recent...
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Early Postnatal Valproic Acid Exposure Increase the Protein Level of Astrocyte Markers in Frontal Cortex of Rat

Mony TJ, Lee JW, Kim SS, Chun W, Lee HJ

OBJECTIVE: In our previous study, it has been reported that valproic acid (VPA) effects gliogenesis and increases the number of glial precursor cells during the early postnatal period. However there...
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Particulate Matter and Cognitive Function

Roh J, Jung HY, Lee KJ

The term “particulate Matter (PM)” refers to the mixture of small-sized solid particles and liquid droplets floating in the air, and is referred to as PM₁₀ ( < 10 µm),...
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T-Type Calcium Channels Are Required to Maintain Viability of Neural Progenitor Cells

Kim JW, Oh HA, Lee SH, Kim KC, Eun PH, Ko MJ, Gonzales E, Seung H, Kim S, Bahn GH, Shin CY

T-type calcium channels are low voltage-activated calcium channels that evoke small and transient calcium currents. Recently, T-type calcium channels have been implicated in neurodevelopmental disorders such as autism spectrum disorder...
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Neonatal Administration of Memantine Enhances Social Cognition in Adult Rats Subjected to Early Maternal Deprivation

Uribe E, Sánchez-Mendoza E, Nieves N, Merchor G

Schizophrenia is considered a neurodevelopmental disorder; however, all the available treatment options are used when the disease becomes clinically significant in adolescence or early adulthood. Using a developmental rat model...
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Use of sugammadex in Rett syndrome: A case report

Kupeli I, Tepe E, Kuyrukluyıldız U

Rett syndrome (RS) is a neurodevelopmental disorder characterized by loss of cognitive, motor, and social skills, epilepsy, autistic behavior, abnormal airway patterns, gastroesophageal reflux, nutritional problems, and severe scoliosis. Although...
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Perfluoroalkyl substances exposure and thyroid hormones in humans: epidemiological observations and implications

Lee JE, Choi K

Thyroid hormones play crucial roles in normal neurodevelopment of fetus and child. Many chemicals can affect control and homeostasis of thyroid hormones, and eventually lead to various adverse health effects...
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Effects of the Female Estrous Cycle on the Sexual Behaviors and Ultrasonic Vocalizations of Male C57BL/6 and Autistic BTBR T+ tf/J Mice

Kim H, Son J, Yoo H, Kim H, Oh J, Han D, Hwang Y, Kaang BK

A primary characteristic of autism, which is a neurodevelopmental disorder, is impaired social interaction and communication. Furthermore, patients with autism frequently show abnormal social recognition. In mouse models of autism,...
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Reliability and Validity of a New Comprehensive Tool for Assessing Challenging Behaviors in Autism Spectrum Disorder

Kim JI, Shin MS, Lee Y, Lee H, Yoo HJ, Kim SY, Kim H, Kim SJ, Kim BN

OBJECTIVE: The purpose of this study was to examine the validity and reliability of the Korean Comprehensive Scale for the Assessment of Challenging Behavior in Developmental Disorders (K-CSCB). METHODS: In total,...
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Valproic Acid Exposure during Early Postnatal Gliogenesis Leads to Autistic-like Behaviors in Rats

Mony TJ, Lee JW, Dreyfus C, DiCicco-Bloom E, Lee HJ

OBJECTIVE: We reported that postnatal exposure of rats to valproic acid (VPA) stimulated proliferation of glial precursors during cortical gliogenesis. However, there are no reports whether enhanced postnatal gliogenesis affects...
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Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders

Kim KC, Gonzales E, Lázaro MT, Choi CS, Bahn GH, Yoo HJ, Shin CY

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and communication impairments, as well as repetitive and restrictive behaviors. The phenotypic heterogeneity of ASD has made it overwhelmingly...
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Pharmacotherapy for attention-deficit/hyperactivity disorder

Kim B

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder defined by impairing levels of inattention, disorganization, and/or hyperactivity-impulsivity. ADHD often persists into adulthood, with resultant impairments of social, academic and occupational functioning....
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