- Ardipusilloside-I stimulates gastrointestinal motility and phosphorylation of smooth muscle myosin by myosin light chain kinase
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Xu Z, Liang H, Zhang M, Tao X, Dou D, Hu L, Kang T
- KMID: 2395255
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):609-616.
- doi: 10.4196/kjpp.2017.21.6.609
Ardipusilloside-I is a natural triterpenoid saponin, which was isolated from Ardisia pusilla A. DC. The aim of the study was to evaluate the stimulation of ardipusilloside-I on gastrointestinal motility in... -
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- Calcium Sensitization Mechanisms in Gastrointestinal Smooth Muscles
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Perrino BA
- KMID: 2203574
- J Neurogastroenterol Motil.
- 2016 Apr;22(2):213-225.
- doi: 10.5056/jnm15186
An increase in intracellular Ca2+ is the primary trigger of contraction of gastrointestinal (GI) smooth muscles. However, increasing the Ca2+ sensitivity of the myofilaments by elevating myosin light chain phosphorylation... -
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- Pulse exposure to ethanol augments vascular contractility through stress response
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Yang EK, Kim IK
- KMID: 1606838
- Korean J Physiol Pharmacol.
- 2001 Feb;5(1):47-53.
Drinking excessive alcohol has been recognized as a risk factor for hypertension. However, the mechanism by which alcohol intake causes hypertension still remains elusive. We tested the hypothesis that ethanol itself acts as... -
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- Ca2+ Sensitization Mechanism in Stretch-induced Myogenic Tone
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Kim JS, Ryu SK, Ahn DS, Kang BS, Lee YH
- KMID: 1614857
- Korean J Physiol Pharmacol.
- 2002 Feb;6(1):33-40.
It has been suggested that Ca2+ sensitization mechanisms might contribute to myogenic tone, however, specific mechanisms have not yet been fully identified. Therefore, we investigated the role of protein kinase... -
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- Ameliorative effects of atractylodin on intestinal inflammation and co-occurring dysmotility in both constipation and diarrhea prominent rats
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Yu C, Xiong Y, Chen D, Li Y, Xu B, Lin Y, Tang Z, Jiang C, Wang L
- KMID: 2371062
- Korean J Physiol Pharmacol.
- 2017 Jan;21(1):1-9.
- doi: 10.4196/kjpp.2017.21.1.1
Intestinal disorders often co-occur with inflammation and dysmotility. However, drugs which simultaneously improve intestinal inflammation and co-occurring dysmotility are rarely reported. Atractylodin, a widely used herbal medicine, is used to... -
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- Olanzapine May Inhibit Colonic Motility Associated with the 5-HT Receptor and Myosin Light Chain Kinase
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Zhang J, Qiao Y, Le J, Sun D, Guan Y, Li Z
- KMID: 2316621
- Psychiatry Investig.
- 2016 Mar;13(2):232-238.
- doi: 10.4306/pi.2016.13.2.232
OBJECTIVE: To study whether the effects of olanzapine on gastrointestinal motility is related to the serotonin antagonism and myosin light chain kinase. METHODS: Male Sprague-Dawley rats were randomly divided into four... -
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- Flavone Attenuates Vascular Contractions by Inhibiting RhoA/Rho Kinase Pathway
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Baek I, Jeon SB, Song MJ, Yang E, Sohn UD, Kim IK
- KMID: 2071672
- Korean J Physiol Pharmacol.
- 2009 Jun;13(3):201-207.
- doi: 10.4196/kjpp.2009.13.3.201
Our previous study demonstrated that flavone inhibits vascular contractions by decreasing the phosphorylation levelof the myosin phosphatase target subunit (MYPT1). In the present study, we hypothesized that flavone attenuates vascular... -
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- Myoplasmic [Ca2+], Crossbridge Phosphorylation and Latch in Rabbit Bladder Smooth Muscle
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Kim YD, Cho MH, Kwon SC
- KMID: 1448921
- Korean J Physiol Pharmacol.
- 2011 Jun;15(3):171-177.
- doi: 10.4196/kjpp.2011.15.3.171
Tonic smooth muscle exhibit the latch phenomenon: high force at low myosin regulatory light chains (MRLC) phosphorylation, shortening velocity (Vo), and energy consumption. However, the kinetics of MRLC phosphorylation and... -
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- Screening and Selection of Proteins Interacting with Myocilin
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Cho MK, Son SS, Kee CW
- KMID: 2337332
- J Korean Ophthalmol Soc.
- 2006 Apr;47(4):637-642.
PURPOSE: To identify novel proteins which bind to myocilin, using a yeast two-hybrid screening system. METHODS: A bait plasmid of myocilin was constructed, and then transformed into yeast AH109. The transformed... -
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- Staurosporine and cytochalasin D induce chondrogenesis by regulation of actin dynamics in different way
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Kim M, Song K, Jin EJ, Sonn J
- KMID: 1389731
- Exp Mol Med.
- 2012 Sep;44(9):521-528.
Actin cytoskeleton has been known to control and/or be associated with chondrogenesis. Staurosporine and cytochalasin D modulate actin cytoskeleton and affect chondrogenesis. However, the underlying mechanisms for actin dynamics regulation... -
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- α-Isocubebene modulates vascular tone by inhibiting myosin light chain phosphorylation in murine thoracic aorta
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Ye BH, Kim EJ, Baek SE, Choi YW, Park SY, Kim CD
- KMID: 2414268
- Korean J Physiol Pharmacol.
- 2018 Jul;22(4):437-445.
- doi: 10.4196/kjpp.2018.22.4.437
α-Iso-cubebene (ICB) is a dibenzocyclooctadiene lignin contained in Schisandra chinensis (SC), a well-known medicinal herb that ameliorates cardiovascular symptoms, but the mechanism responsible for this activity has not been determined.... -
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- Cardiac Hypertrophy in Transgenic Mice with Overexpressed Small-Subunit of Human Myosin Light Chain Phosphatase
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Bae SW, Lee WH, Kim CH, Park HK, Lee SC, Ko YH, Park SW, Arimura T, Kimura A, Park JE
- KMID: 2227250
- Korean Circ J.
- 2003 Dec;33(12):1165-1173.
- doi: 10.4070/kcj.2003.33.12.1165
BACKGROUND AND OBJECTIVES: Recent reports have demonstrated that perturbation of the balance between myo-sin light chain (MLC) phosphorylation and the dephosphorylation status is associated with the development of cardiac hypertrophy.... -
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- Doxorubicin Promotes Migration and Invasion of Breast Cancer Cells through the Upregulation of the RhoA/MLC Pathway
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Liu CL, Chen MJ, Lin JC, Lin CH, Huang WC, Cheng SP, Chen SN, Chang YC
- KMID: 2450114
- J Breast Cancer.
- 2019 Jun;22(2):185-195.
- doi: 10.4048/jbc.2019.22.e22
PURPOSE: Cancer cells develop acquired resistance induced by chemotherapeutic drugs. In this study, we investigated the effects of brief treatment with cytotoxic drugs on the phenotype of breast cancer cells. METHODS:... -
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- Ca2+/Calmodulin-Dependent and -Independent Mechanisms are Involved in Angiotension II-induced Contraction of Rat Aortic Smooth Muscle
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Lee BD, Choi SJ, Kim SJ, Lim SW
- KMID: 1936947
- Korean J Anesthesiol.
- 2005 Jul;49(1):86-95.
- doi: 10.4097/kjae.2005.49.1.86
BACKGROUND: Angiotensin II (Ang II) appears to play important roles in the pathogenesis of hypertension. However, the mechanism by which Ang II induces vascular smooth muscle contraction is not... -
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- A Comparative Study of Gene Expression Patterns of Periodontal Ligament Cells and Gingival Fibroblasts using the cDNA Microarray
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Jeon CY, Park JW, Lee JM, Suh JY
- KMID: 1962491
- J Korean Acad Periodontol.
- 2004 Mar;34(1):205-221.
- doi: 10.5051/jkape.2004.34.1.205
Periodontal ligament(PDL) cells have been known as playing an important roles in periodontal regeneration and gingival fibroblasts are also important to periodontal regeneration by forming connective tissue attachment. There were... -
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- High fat diet confers vascular hyper-contractility against angiotensin II through upregulation of MLCK and CPI-17
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Kim JI
- KMID: 2371073
- Korean J Physiol Pharmacol.
- 2017 Jan;21(1):99-106.
- doi: 10.4196/kjpp.2017.21.1.99
Obesity is a critical risk factor for the hypertension. Although angiotensin II (Ang II) in obese individuals is known to be upregulated in obesity-induced hypertension, direct evidence that explains the... -
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- Effect of Heat Shock on the Vascular Reactivity in Diabetic Rat Aorta
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Koo SM, Lee SH, Han JH, Jeong GY, Kim IK, Kim JG, Ha SW, Kim BW
- KMID: 2177848
- J Korean Diabetes Assoc.
- 2001 Oct;25(5):343-353.
BACKGROUND: Heat shock has been known to change cellular response to noxious stimuli by inducing heat shock proteins (HSP). HSP are expressed in many tissues, and increased expression of... -
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- G protein-coupled receptor signaling in gastrointestinal smooth muscle
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Sohn UD, Kim DS, Murthy KS
- KMID: 2071568
- Korean J Physiol Pharmacol.
- 2001 Aug;5(4):287-297.
Contraction of smooth muscle is initiated by an increase in cytosolic Ca2+ leading to activation of Ca2+/calmodulin-dependnet myosin light chain (MLC) kinase and phosphorylation of MLC. The types of contraction and signaling mechanisms... -
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- Rho-Associated Kinase 2 Polymorphism in Patients With Vasospastic Angina
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Yoo SY, Kim J, Cheong S, Shin DH, Jang J, Lee C, Tahk SJ, Shin JH, Choi SY, Yoon MH
- KMID: 1433860
- Korean Circ J.
- 2012 Jun;42(6):406-413.
- doi: 10.4070/kcj.2012.42.6.406
BACKGROUND AND OBJECTIVES: Recent studies indicate that in response to vasoconstrictor stimuli, the small GTPase RhoA and its down-stream effector, Rho-associated kinase 2 (ROCK)/Rho-kinase, are associated with hypercontraction of the... -
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- Proteomic analyses of cervical cancer tissues by two-dimensional gel electrophoresis and mass spectrometry
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Lee SH, Bae SM, Kim OK, Kim HJ, Park EK, Lee HN, Kim YW, Ro DY, Lee JM, Namkoong S, Cho YL, Nam GH, Han BD, Kim YW, Kim CK, Ahn WS
- KMID: 2272627
- Korean J Obstet Gynecol.
- 2005 Jul;48(7):1686-1697.
OBJECTIVE: Comparison of protein expressions by two-dimensional gel electrophoresis (2-DE) in normal cervix and squamous cell carcinoma tissues in Korean women. METHODS: Normal cervix and squamous cell carcinoma tissues were solubilized... -
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