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Detection of Myocardial Metabolic Abnormalities by 18F-FDG PET/CT and Corresponding Pathological Changes in Beagles with Local Heart Irradiation

Yan R, Song J, Wu Z, Guo M, Liu J, Li J, Hao X, Li S

OBJECTIVE: To determine the efficacy of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in the detection of radiation-induced myocardial damage in beagles by comparing two pre-scan preparation protocols as well...
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Time-Dependent Expression Patterns of Cardiac Aquaporins Following Myocardial Infarction

Zhang HZ, Kim MH, Lim JH, Bae HR

Aquaporins (AQPs) are expressed in myocardium and the implication of AQPs in myocardial water balance has been suggested. We investigated the expression patterns of AQP subtypes in normal myocardium and...
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Post-mortem re-cloning of a transgenic red fluorescent protein dog

Hong SG, Koo OJ, Oh HJ, Park JE, Kim M, Kim GA, Park EJ, Jang G, Lee BC

Recently, the world's first transgenic dogs were produced by somatic cell nuclear transfer. However, cellular senescence is a major limiting factor for producing more advanced transgenic dogs. To overcome this...
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Involvement of GADD153 and cardiac ankyrin repeat protein in cardiac ischemia-reperfusion injury

Lee MJ, Kwak YK, You KR, Lee BH, Kim DG

Oxidative stress is critical for causing cardiac injuries during ischemia-reperfusion (IR), yet the molecular mechanism for this remains unclear. In the present study, we observe that hypoxia and reoxygenation, a...
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In vivo targeting of ERGpotassiumchannels inmice and dogs by a positron-emitting analogue of fluoroclofilium

Kim SW, Yang SD, Ahn BJ, Park JH, Lee DS, Gessner G, Heinemann , Herdering , Yu KH

  • KMID: 1093461
  • Exp Mol Med.
  • 2005 Aug;37(4):269-275.
The antiarrhythmic clofilium is an efficient blocker of hERG1 potassium channels that are strongly expressed in the heart. Therefore, derivatives of clofilium that emit positrons might be useful tools for...
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Gene expression profiling of oxidative stress on atrial fibrillation in humans

Kim YH, Lee JH, Lim DS, Shim WJ, Ro YM, Park GH, Becker KG, Cho-Chung , Kim MK

  • KMID: 1093605
  • Exp Mol Med.
  • 2003 Oct;35(5):336-349.
Atrial Fibrillation (AF) is thought be caused by oxidative stress. Oxidative stress at the cellular level results from many factors, including exposure to alcohol, medications, cold, toxins or radiation. In...
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Assessment of myocardial metaiodobenzylguanidine uptake and its relation to left ventricular systolic and diastolic functional parameters in dilated cardiomyopathy

Ha JW, Lee JD, Chung N, Jang Y, Cho SH, Kim BS, Rim SJ, Shim WH, Cho SY, Kim SS

The purpose of this study was to assess the relation between myocardial metaiodobenzylguanidine (MIBG) uptake and left ventricular systolic and diastolic functional parameters, both of which are known...
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Time-dependent expression of ICAM-1 & VCAM-1 on coronaries of the heterotopically transplanted mouse heart

Lee JR, Huh JH, Seo JW, Suk CJ, Jeong HM, Kim EK

To investigate the pathogenesis of accelerated graft atherosclerosis after rdiac transplantation, a genetically well-defined and reproducible animal del is required. We performed heterotopic intraabdominal heart transplantation tween the two inbred...
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Fluoxetine inhibits L-type Ca2+ and transient outward K+ currents in rat ventricular myocytes

Park KS, Kong ID, Park KC, Lee JW

The most common cardiovascular side effects of antidepressants are cardiac arrhythmias and orthostatic hypotension. Little is known, however, about the mechanisms by which these adverse reactions may occur,...
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Increased expression of Galphaq protein in the heart of streptozotocin-induced diabetic rats

Yang JM, Cho CH, Kong KA, Jang IS, Kim HW, Juhnn YS

  • KMID: 1029924
  • Exp Mol Med.
  • 1999 Dec;31(4):179-184.
Heart disease is one of the major cause of death in diabetic patients, but the thogenesis of diabetic cardio-myopathy remains unclear. In this experiment, to sess the significance...
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Cardioprotective drugs decrease the Na+ background current

Park SR, Ryu GH, Suh CK

Cardiac dysfunctions such as myocardial functional failure and ventricular arrhythmia have been largely attributed to intracellular Ca2+ overload. One of the mechanisms of intracellular Ca2+ overload involves a rapid influx...
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Relation between ischemic preconditioning and the duration of sustained ischemia

Kim DJ, Kim H, Park JI, Shim TS, Rah BJ, Kim HD

It has been reported that repetitive brief periods of ischemia and reperfusion (ischemic preconditioning, IP) cause a significant reduction in the extent of myocardial necrosis or in the incidence of...
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Effects of Drugs on the Interaction of Calcium and Cardiac Muscle Memberane Fragments

Kang DH, Lee JW, Chung KS

The effect of drugs on calcium-binding to cardiac muscle membrane fragments and its turnover rate was studied. Ouabian, acetylcholine, isoproterenol and norepinephrine did not have any effect either on calcium-binding...
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Kanamycin as a Ca++ Antagonist

Lee JW, Kang BS, Kang DH

In order to elucidate mechanisms of Ca++ antagonistic action of kanamycin in the biological system, the effects of kanamycin on Ca++ transport in sarcoplasmic reticulum of rabbit skeletal muscle and...
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Effect of Thyroxine on the Cardiac Uptake of Catecholamines

Yoo CS, Chu YM, Lee WC

The influence of thyroxine upon n the cardiac uptake of catecholamines was investigated in rabbits. A single injection of thyroxine(1.0m/kg) into rabbits did not affect the concentration of myocardial catecholamines....
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Effect of Hypophysectomy, Adrenalectomy, and Thyroidectomy on the Beta-Cells of the Islets of Langerhans of the Pancreas

Lee HJ, Lee YB, Kim DS

Prolonged administration of anterior hypophyseal, adrenocortical, or thyroid hormones is known to cause degeneration, degranulation and necrosis of the beta-cells in the Langerhans islets of the pancreas. However, the effects...
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