Yonsei Med J.  1982 Jun;23(1):1-7. 10.3349/ymj.1982.23.1.1.

Effects of Drugs on the Interaction of Calcium and Cardiac Muscle Memberane Fragments

• Kang DH
• Lee JW
• Chung KS

• KMID: 1729486
• DOI: http://doi.org/10.3349/ymj.1982.23.1.1

Abstract

The effect of drugs on calcium-binding to cardiac muscle membrane fragments and its turnover rate was studied. Ouabian, acetylcholine, isoproterenol and norepinephrine did not have any effect either on calcium-binding to membrane fragments or an washout ahnd release curves of previously bound calcium. Local anesthetics inhibited the calcium-binding. Tetracaine at concentrations of 1 and 10 mM inhibited the calcium-binding by 30% and 54%, respectively, while 10 mM lidocaine inhibited it by 17%. Propranolol, a well-known adrenergic beta-blocker, also inhibited calcium-binding at the external calcium concentration of 10(-3) M. This effect of propranolol may be attributed to its local anesthetic-like action, rather than to the adrenergic blocking effect.

Keyword

Cardiac muscle membrane; calcium ion; cardioactive drugs

MeSH Terms

Anesthetics, Local/pharmacology*
Animal
Calcium/metabolism*
Cardiotonic Agents/pharmacology*
Cell Membrane/metabolism
In Vitro
Myocardium/metabolism*