- Segregation Analysis in Genetic Epidemiology
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Jee SH
- KMID: 2304054
- Korean J Epidemiol.
- 1997 Dec;19(2):95-102.
Genetic epidemiology is an emerging field with diverse interests, one that represents an important interaction between the two parent disciplines: genetics and epidemiology. Segregation analysis was originally designed to test... -
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- Use of Behavioral Analysis in Animal Models for Schizophrenia Research
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Woo Y, Lee S, Jeong J, Park SK
- KMID: 2288295
- Korean J Schizophr Res.
- 2014 Apr;17(1):12-26.
- doi: 10.16946/kjsr.2014.17.1.12
Animal models are useful tools to study the molecular basis of schizophrenia pathophysiology and efficacy of potential therapeutic agents. Schizophrenia animal models can be subdivided into three classes ; drug-induced... -
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- Animal Models of Neurodegenerative Diseases
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Cho SR
- KMID: 1445606
- Brain Neurorehabil.
- 2011 Mar;4(1):30-34.
- doi: 10.12786/bn.2011.4.1.30
Animal models of human diseases are essentially required to investigate the pathophysiological mechanisms of the diseases, and to test potential therapies for the clinics. However, neurodegenerative diseases including Parkinson's disease... -
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- Evolutionary Genetic Models of Mental Disorders
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Park H
- KMID: 2469513
- Korean J Biol Psychiatry.
- 2019 Oct;26(2):33-38.
- doi: 10.0000/kjbp.2019.26.2.33
Psychiatric disorder as dysfunctional behavioural syndrome is a paradoxical phenomenon that is difficult to explain evolutionarily because moderate prevalence rate, high heritability and relatively low fitness are shown. Several evolutionary... -
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- Genetic and Environmental Influences on Birthweight in a Sample of Korean Twins
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Hur YM
- KMID: 1778489
- J Korean Med Sci.
- 2005 Jun;20(3):355-360.
- doi: 10.3346/jkms.2005.20.3.355
This study is the first report of genetic and environmental influences on birthweight using Korean twins. The sample consisted of 255 monozygotic (MZ) and 178 dizygotic (DZ) twin pairs drawn... -
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- Role of Serotonin in the Pathology and Treatment of Violence and Suicide
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Chung IW
- KMID: 2202979
- J Korean Soc Biol Psychiatry.
- 1997 Nov;4(2):188-193.
Along with psychosocial factors of suicide, biological backgrounds of suicide are explored by extensive works mostly on biological markers, neurobiological models, genetic bases, and relationship with aggression and violence. The... -
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- Meta-analysis for genome-wide association studies using case-control design: application and practice
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Shim S, Kim J, Jung W, Shin IS, Bae JM
- KMID: 2380748
- Epidemiol Health.
- 2016;38:e2016058.
- doi: 10.4178/epih.e2016058
This review aimed to arrange the process of a systematic review of genome-wide association studies in order to practice and apply a genome-wide meta-analysis (GWMA). The process has a series... -
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- Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders
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Kim KC, Gonzales E, Lázaro MT, Choi CS, Bahn GH, Yoo HJ, Shin CY
- KMID: 2164215
- Biomol Ther.
- 2016 May;24(3):207-243.
- doi: 10.4062/biomolther.2016.061
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by social and communication impairments, as well as repetitive and restrictive behaviors. The phenotypic heterogeneity of ASD has made it overwhelmingly... -
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- Sample Size and Statistical Power Calculation in Genetic Association Studies
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Hong EP, Park JW
- KMID: 2166494
- Genomics Inform.
- 2012 Jun;10(2):117-122.
- doi: 10.5808/GI.2012.10.2.117
A sample size with sufficient statistical power is critical to the success of genetic association studies to detect causal genes of human complex diseases. Genome-wide association studies require much larger... -
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- Association between a Genetic Variant of CACNA1C and the Risk of Schizophrenia and Bipolar I Disorder Across Diagnostic Boundaries
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Lee B, Baek JH, Cho EY, Yang SY, Choi YJ, Lee YS, Ha K, Hong KS
- KMID: 2423026
- Korean J Schizophr Res.
- 2018 Oct;21(2):43-50.
- doi: 10.16946/kjsr.2018.21.2.43
OBJECTIVES: Genome-wide association studies (GWASs) and meta-analyses indicate that single-nucleotide polymorphisms (SNPs) in the a-1C subunit of the L-type voltage-dependent calcium channel (CACNA1C) gene increase the risk for schizophrenia and... -
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- Association of UCP1 Genetic Polymorphisms with Blood Pressure among Korean Female Subjects
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Cha MH, Kang BK, Suh D, Kim KS, Yang Y, Yoon Y
- KMID: 1783060
- J Korean Med Sci.
- 2008 Oct;23(5):776-780.
- doi: 10.3346/jkms.2008.23.5.776
Recent studies have provided some clues with regard to the relationship existing between uncoupling protein 1 (UCP1) and blood pressure in animal experiments. In an attempt to determine the genetic... -
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- Identification of PSEN1 and APP Gene Mutations in Korean Patients with Early-Onset Alzheimer's Disease
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Park HK, Na DL, Lee JH, Kim JW, Ki CS
- KMID: 1713451
- J Korean Med Sci.
- 2008 Apr;23(2):213-217.
- doi: 10.3346/jkms.2008.23.2.213
Although mutations in three genes, amyloid precursor protein (APP), presenilin 1 (PSEN1), and presenilin 2 (PSEN2), have been identified as genetic causes of earlyonset Alzheimer s disease (EOAD), there has... -
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- A Functional Polymorphism in the DRD1 Gene, That Modulates Its Regulation by miR-504, Is Associated with Depressive Symptoms
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Jiménez K, Pereira-Morales AJ, Forero DA
- KMID: 2411393
- Psychiatry Investig.
- 2018 Apr;15(4):402-406.
- doi: 10.30773/pi.2017.10.16.1
OBJECTIVE: The aim of this study was to examine a possible association between depressive symptoms and a functional polymorphism (rs686) that modulates the regulation of DRD1 gene by miR-504. METHODS: A... -
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- Association of Single Nucleotide Polymorphisms in Toll-like Receptor Genes With Asthma Risk: a Systematic Review and Meta-analysis
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Tizaoui K, Kaabachi W, Hamzaoui K, Hamzaoui A
- KMID: 2365541
- Allergy Asthma Immunol Res.
- 2015 Mar;7(2):130-140.
- doi: 10.4168/aair.2015.7.2.130
PURPOSE: Asthma is a complex disease, with contributions from multiple genes, various genetic backgrounds, and environmental factors. Many human epidemiological studies have demonstrated that single nucleotide polymorphisms (SNPs) in Toll-like... -
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- WDR46 is a Genetic Risk Factor for Aspirin-Exacerbated Respiratory Disease in a Korean Population
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Pasaje CF, Bae JS, Park BL, Cheong HS, Kim JH, Uh ST, Park CS, Shin HD
- KMID: 1970708
- Allergy Asthma Immunol Res.
- 2012 Jul;4(4):199-205.
- doi: 10.4168/aair.2012.4.4.199
PURPOSE: The human WD repeat-containing protein 46 (WDR46; also known as C6orf11), located at the disease-relevant centromere side of the class II major histocompatibility complex region, is hypothesized to be... -
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- A clinicogenetic model to predict lymph node invasion by use of genome-based biomarkers from exome arrays in prostate cancer patients
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Oh JJ, Park S, Lee SE, Hong SK, Lee S, Lee HM, Lee JK, Ho JN, Yoon S, Byun SS
- KMID: 2133274
- Korean J Urol.
- 2015 Feb;56(2):109-116.
- doi: 10.4111/kju.2015.56.2.109
PURPOSE: Genetic variations among prostate cancer (PCa) patients who underwent radical prostatectomy (RP) and pelvic lymph node dissection were evaluated to predict lymph node invasion (LNI). Exome arrays were used... -
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- Rh C/c , E/e genotyping by polymerase chain reaction using sequence - specific primers
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Hwang YS, Oh HB, Kim SI, Seo DH
- KMID: 1838435
- J Korean Soc Microbiol.
- 1999 Feb;34(1):21-26.
BACKGROUNDS: With the recent elucidation of genetic basis of Rh blood group, it is now available the molecular genotyping methods for Rh blood typing. These can be used when serological... -
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- Rh C/c, E/e genotyping by polymerase chain reaction using sequence-specific primers
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Seo DH, Oh HB, Hwang YS, Kim SI
- KMID: 1862938
- Korean J Blood Transfus.
- 1999 May;10(1):21-26.
BACKGROUNDS: With the recent elucidation of genetic basis of Rh blood group, it is now available the molecular genotyping methods for Rh blood typing. These can be used when serological... -
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- p22phox C242T gene polymorphism and overt diabetic nephropathy: a meta-analysis of 1,452 participants
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Li YY, Gong G, Geng HY, Qian Y
- KMID: 2396764
- Korean J Intern Med.
- 2017 Nov;32(6):1045-1052.
- doi: 10.3904/kjim.2015.106
BACKGROUND/AIMS: The p22phox C242T gene polymorphism (rs4673) may be linked to an increased susceptibility for overt diabetic nephropathy (ODN), but the study results are still inconclusive. METHODS: To explore the relationship... -
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- LPL gene Pvu II polymorphism and hypertriglyceridemia: a meta-analysis involving 1,640 subjects
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Li YY, Zhou YH, Gong G, Geng HY, Yang XX, Wang XM, Zhou CW, Xu J, Qian Y
- KMID: 2396761
- Korean J Intern Med.
- 2017 Nov;32(6):1018-1024.
- doi: 10.3904/kjim.2016.043
BACKGROUND/AIMS: Although lipoprotein lipase (LPL) gene Pvu II polymorphism has been associated with an increased risk of hypertriglyceridemia (HT), there is no clear consensus within the scientific community. METHODS: A meta-analysis... -
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