- Luteolin 5-O-glucoside from Korean Milk Thistle, Cirsium maackii, Exhibits Anti-Inflammatory Activity via Activation of the Nrf2/HO-1 Pathway
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Jung HA, Roy A, Abdul QA, Kim HR, Park HJ, Choi JS
- KMID: 2393799
- Nat Prod Sci.
- 2017 Sep;23(3):183-191.
- doi: 10.20307/nps.2017.23.3.183
Luteolin 5-O-glucoside is the major flavonoid from Korean thistle, Cirsium maackii. We previously reported the anti-inflammatory activities of luteolin 5-O-glucoside in lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. In this study, we... -
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- Silymarin Inhibits Cytokine-Stimulated Pancreatic Beta Cells by Blocking the ERK1/2 Pathway
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Kim EJ, Kim J, Lee MY, Sudhanva M, Devakumar , Jeon YJ
- KMID: 2170620
- Biomol Ther.
- 2014 Jul;22(4):282-287.
We show that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibits cytokine mixture (CM: TNF-alpha, IFN-gamma, and IL-1beta)-induced production of nitric oxide (NO) in the pancreatic beta... -
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- Silymarin Inhibits Morphological Changes in LPS-Stimulated Macrophages by Blocking NF-kappaB Pathway
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Kim EJ, Lee MY, Jeon YJ
- KMID: 1791421
- Korean J Physiol Pharmacol.
- 2015 May;19(3):211-218.
- doi: 10.4196/kjpp.2015.19.3.211
The present study showed that silymarin, a polyphenolic flavonoid isolated from milk thistle (Silybum marianum), inhibited lipopolysaccharide (LPS)-induced morphological changes in the mouse RAW264.7 macrophage cell line. We also showed... -
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- Inhibition of Wnt Signaling by Silymarin in Human Colorectal Cancer Cells
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Eo HJ, Park GH, Jeong JB
- KMID: 2351686
- Biomol Ther.
- 2016 Jul;24(4):380-386.
- doi: 10.4062/biomolther.2015.154
Silymarin from milk thistle (Silybum marianum) has been reported to show an anti-cancer activity. In previous study, we reported that silymarin induces cyclin D1 proteasomal degradation through NF-κB-mediated threonine-286 phosphorylation.... -
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- Protective Effects of Silibinin and Its Possible Mechanism of Action in Mice Exposed to Chronic Unpredictable Mild Stress
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Yan WJ, Tan YC, Xu JC, Tang XP, Zhang C, Zhang PB, Ren ZQ
- KMID: 2380334
- Biomol Ther.
- 2015 May;23(3):245-250.
- doi: 10.4062/biomolther.2014.138
Silibinin, a natural flavonoid antioxidant isolated from extracts of the milk thistle herb, has recently been identified as having anti-hepatotoxic and anticancer properties. In this paper, we investigated the effects... -
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- Inhibition of ERK1/2 by silymarin in mouse mesangial cells
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Youn CK, Cho SI, Lee MY, Jeon YJ, Lee SK
- KMID: 2371075
- Korean J Physiol Pharmacol.
- 2017 Jan;21(1):117-124.
- doi: 10.4196/kjpp.2017.21.1.117
The present study aimed to show that pro-inflammatory cytokines [tumor necrosis factor (TNF)-α, interferon (IFN)-γ, and interleukin (IL)-1β] synergistically induce the production of nitric oxide (NO) production in mouse mesangial... -
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- Silibinin Enhances Ultraviolet B-Induced Apoptosis in MCF-7 Human Breast Cancer Cells
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Noh EM, Yi MS, Youn HJ, Lee BK, Lee YR, Han JH, Yu HN, Kim JS, Jung SH
- KMID: 2175636
- J Breast Cancer.
- 2011 Mar;14(1):8-13.
- doi: 10.4048/jbc.2011.14.1.8
PURPOSE: Chemotherapies for breast cancer generally have strong cellular cytotoxicity and severe side effects. Thus, significant emphasis has been placed on combinations of naturally occurring chemopreventive agents. Silibinin is a... -
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- Silibinin Inhibits LPS-Induced Macrophage Activation by Blocking p38 MAPK in RAW 264.7 Cells
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Youn CK, Park SJ, Lee MY, Cha MJ, Kim OH, You HJ, Chang IY, Yoon SP, Jeon YJ
- KMID: 2170670
- Biomol Ther.
- 2013 Jul;21(4):258-263.
We demonstrate herein that silibinin, a polyphenolic flavonoid compound isolated from milk thistle (Silybum marianum), inhibits LPS-induced activation of macrophages and production of nitric oxide (NO) in RAW 264.7 cells.... -
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- Protective and therapeutic effects of an extract mixture of alder tree, labiate herb, milk thistle green bean-rice bran fermentation, and turnip against ethanol-induced toxicity in the rat
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Baek MW, Seok SH, Lee HY, Kim DJ, Lee BH, Ahn YT, Lim KS, Huh CS, Park JH
- KMID: 1102951
- J Vet Sci.
- 2008 Mar;9(1):31-37.
- doi: 10.4142/jvs.2008.9.1.31
An herbal extract mixture and yogurt added to the herbal extract mixture were tested for their protective and therapeutic effects on ethanol-induced liver injury. The herbal extract mixture, yogurt and... -
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- Beneficial Effects of Silibinin Against Kainic Acid-induced Neurotoxicity in the Hippocampus in vivo
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Kim S, Jung UJ, Oh YS, Jeon MT, Kim HJ, Shin WH, Hong J, Kim SR
- KMID: 2398431
- Exp Neurobiol.
- 2017 Oct;26(5):266-277.
- doi: 10.5607/en.2017.26.5.266
Silibinin, an active constituent of silymarin extracted from milk thistle, has been previously reported to confer protection to the adult brain against neurodegeneration. However, its effects against epileptic seizures have... -
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- Determination of Silybin B in the Different Parts of Silybum marianum using HPLC-UV
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Rodriguez , Quilantang NG, Lee JS, Lee JM, Kim HY, Shim JS, Lee S
- KMID: 2416066
- Nat Prod Sci.
- 2018 Jun;24(2):82-87.
- doi: 10.20307/nps.2018.24.2.82
Silymarin is the standardized extract from Silybum marianum which consists mainly of flavonoids and polyphenols. It is highly regarded for its hepatoprotective ability. Silybin B is a flavonolignan and one... -
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- Protective effect of the aerial parts of Silybum marianum against amyloid β protein (25-35)-induced neuronal death in cultured neurons
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Lee HM, Jang JY, Seong YH
- KMID: 2368692
- J Biomed Transl Res.
- 2016 Dec;17(4):109-114.
- doi: 10.12729/jbtr.2016.17.4.109
Alzheimer's disease (AD), a progressive neurodegenerative disorder that deprives the patient of memory, is associated mainly with extracellular senile plaque induced by the accumulation of amyloid β protein (Aβ). Silybum... -
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- Picroside II attenuates fatty acid accumulation in HepG2 cells via modulation of fatty acid uptake and synthesis
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Dhami-Shah H, Vaidya R, Udipi S, Raghavan S, Abhijit S, Mohan V, Balasubramanyam M, Vaidya A
- KMID: 2429085
- Clin Mol Hepatol.
- 2018 Mar;24(1):77-87.
- doi: 10.3350/cmh.2017.0039
BACKGROUND/AIMS: Hepatic steatosis is caused by an imbalance between free fatty acids (FFAs) uptake, utilization, storage, and disposal. Understanding the molecular mechanisms involved in FFAs accumulation and its modulation could... -
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