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Clostridium botulinum toxin A significantly inhibits uterine contractions in rats undergoing mifepristone-induced preterm labor

Jang HY, Lee KM, Park YS, Moon MJ, Hahn WB, Ahn EH

OBJECTIVE: We investigated the in vivo tocolytic effect of Clostridium botulinum toxin A (BoNT/A) on mifepristone-induced preterm labor in rats. METHODS: On day 17 of gestation, an incision was made to...
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Influence of Estrogen and Polyamines on Mifepristone-induced Apoptosis in Prostate Cancer Cells

Choi EK, Song HJ, Park MS, Kim BG

  • KMID: 1807312
  • Cancer Res Treat.
  • 2004 Feb;36(1):85-90.
PURPOSE: Although androgens are the main steroids controlling the growth of prostate glands, estrogens are also important in the regulation of its growth. Prostate cancer cells, like other cancer cells,...
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Postcoital Contraceptive Pills

Lee JP

Postcoital contraception or emergency contraception(EC), commonly known as the "morning after pills", prevents pregnancy after unprotected intercourse. A comprehensive definition of EC is as follows : "specific contraceptive methods that...
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Effect of ovarian on FSH release and subunit synthesis in rat anterior pituitary cells in culture

Kim YK, Kim KH

  • KMID: 2261258
  • Korean J Obstet Gynecol.
  • 1999 Jan;42(1):41-47.
OBJECTIVE: to determine whether ovarian steroids directly regulate FSH release and B subunit synthesis at the pituitary level METHODS: In vitro study. After applying ovarian steroids in cultured rat anterior...
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The Effect of Bacterial Lipopolysaccharide on the Lymphokine Production of the T Lymphocytes

Moon HB, Yun KJ, Han WC, Lim CW, Kwon HN, Park YS

  • KMID: 1725230
  • Korean J Pathol.
  • 1997 Mar;31(3):244-251.
It is well known that the murine T helper cell clones are divided by their lymphokine secretory activities. One is the Th-1 cell, producing IL-2 and IFN after...
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The Effects of Steroid and Steroid Receptor Blocker in Initial Polyp Formation

Park CH, Na SK, Lim HJ, Jung YG

  • KMID: 2274785
  • Korean J Otolaryngol-Head Neck Surg.
  • 2000 Dec;43(12):1312-1317.
BACKGROUND AND OBJECTIVES: The epithelial rupture theory for the polyp formation has been well approved. According to Norlander et al., the polyp formation initiated by multifactorial pathophysiological events (infection/inflammation) appears...
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Effect of GRbeta expression on steroid-induced transcriptional activity in airway epithelial cells

Jee YK, Kim YS, Park JS, Lee KY

  • KMID: 2178420
  • J Asthma Allergy Clin Immunol.
  • 2003 Dec;23(4):810-817.
BACKGROUND: It has been known that GRbeta(90 kDa), an alternative splicing variant, can not bind ligand and may act as a domiant negative inhibitor of GRalpha. But there is little...
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Role of Glucocorticoid Receptor on Insulin Secretion and Synthesis in INS-1 Cells

Yang JY, Kang MS, Song TH, Jeong IK, Seo PJ, Kim HJ

  • KMID: 2331791
  • J Korean Diabetes Assoc.
  • 2006 Nov;30(6):428-434.
BACKGROUND: Glucocorticoids play important roles in the regulation of glucose homeostasis. It is well known that glucocorticoids reduce hepatic and peripheral tissue sensitivity to insulin, but the roles of glucocorticoids...
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Vasoactive Intestinal Peptide Induces MUC2/5AC Synthesis in Human Airway Epithelial Cells

Kim YD, Chang KY, Sin JH, Kwak DS, Lee HJ, Song SY, Song KW

  • KMID: 2074510
  • Korean J Otolaryngol-Head Neck Surg.
  • 2004 Jul;47(7):639-644.
BACKGROUND AND OBJECTIVES: Vasointestinal peptide (VIP) is an important neurotransmitter involved in the regulation of mucus secretion, but the relationship of VIP and mucin genes is not clear. This study...
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Budesonide Down-regulates IL-1beta-Mediated MUC2/MUC5AC Genes Expression and Mucin Secretion in Human Airway Epithelial Cells

Kim YD, Cho JS, Chang KY, Sin JH, Song SY, Yoon SK

  • KMID: 2141380
  • Korean J Otolaryngol-Head Neck Surg.
  • 2002 Sep;45(9):873-877.
BACKGROUND AND OBJECTIVES: Mucus hypersecretion is a hallmark of many respiratory inflammatory diseases such as asthma, bronchitis and sinusitis. While the current therapeutic pharmacological approaches to reducing mucus hypersecretion are...
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Dexamethasone Inhibits Interleukin-1beta-Induced Matrix Metalloproteinase-9 Expression in Cochlear Cells

Nam SI, Kwon TK

OBJECTIVES: To investigate the effect of interleukin (IL)-1beta on matrix metalloproteinase (MMP)-9 expression in cochlea and regulation of IL-1beta-mediated MMP-9 expression by dexamethasone and the molecular and signaling mechanisms involved. METHODS:...
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Dexamethasone Inhibits TRAIL- and Anti-cancer Drugs-induced Cell Death in A549 Cells through Inducing NF-kappaB-independent cIAP2 Expression

Kim YS, Park JS, Jee YK, Lee KY

  • KMID: 1804569
  • Cancer Res Treat.
  • 2004 Oct;36(5):330-337.
PURPOSE: We have examined that dexamethasone inhibits apoptotic cell death of A549 lung epithelial cells through TRAIL and anti-cancer drugs. The purpose of the study is to determine the roles...
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Regulation of Estrogen Receptor and Progesterone Receptor Expression by Estrogen and Progesterone/Progestogen in Human Umbilical Vein Endothelial Cells

Lee WJ, Cho SH

  • KMID: 1925283
  • Korean J Obstet Gynecol.
  • 2003 Dec;46(12):2352-2359.
OBJECTIVE: Observational studies showed a significant reduction in cardiovascular disease (CVD) among postmenopausal hormone replacement therapy (HRT) users. But recent randomized clinical trial reported that HRT does not decrease, and...
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The Effects of Progesterone on Cell Mediated Immunity to Trophoblast in Women with Recurrent Pregnancy Loss

Choi BC, Hill JA

  • KMID: 2235775
  • Korean J Fertil Steril.
  • 1997 Dec;24(3):399-405.
Progesterone is necessary for successful pregnancy and had immunosuppressive properties. Peripheral blood mononuclear cells (PBMC) from many women with unexplained recurrent spontaneous abortion responded to trophoblast extract in vitro by...
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Direct Corticosteroid Modulation of GABAergic Neurons in the Anterior Hypothalamic Area of GAD65-eGFP Mice

Shin SY, Han TH, Lee SY, Han SK, Park JB, Erdelyi F, Szabo G, Ryu PD

Corticosterone is known to modulate GABAergic synaptic transmission in the hypothalamic paraventricular nucleus. However, the underlying receptor mechanisms are largely unknown. In the anterior hypothalamic area (AHA), the sympathoinhibitory center...
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Expression and regulation of Enpp2 in rat uterus during the estrous cycle

Ahn HJ, Yang H, An BS, Choi KC, Jeung EB

Ectonucleotide pyrophosphatase/phosphodiestrase 2 (Enpp2) isolated from the supernatant of human melanoma cells is a lysophospholipase D that transforms lysophosphatidylcholine into lysophospatidic acid. Although multiple analyses have investigated the function of...
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Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat

Kang JW, Kim TW, La JH, Sung TS, Kim HJ, Kwon YB, Kim JY, Yang IS

  • KMID: 1099831
  • J Vet Sci.
  • 2004 Sep;5(3):189-195.
The effect of electroacupuncture (EA) on experimental colitis was investigated in Sprague-Dawley rats. Colitis was induced by intracolonic instillation of 4% acetic acid. EA (2 Hz, 0.05 ms, 2 V...
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