J Vet Sci.
2004 Sep;5(3):189-195.
Electroacupuncture ameliorates experimental colitis induced by acetic acid in rat
- Affiliations
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- 1Department of Physiology, College of Veterinary Medicine, Seoul National University, Seoul 151-742, Korea. isyang@snu.ac.kr
- 2Department of Physiology, College of Veterinary Medicine, Kyungpuk National University, Daegu 712-715, Korea.
- 3Institute of Bioscience and Biotechnology, Daewoong Pharm Co. LTD., Yongin 449-814, Korea.
Abstract
- The effect of electroacupuncture (EA) on experimental colitis was investigated in Sprague-Dawley rats. Colitis was induced by intracolonic instillation of 4% acetic acid. EA (2 Hz, 0.05 ms, 2 V for 20min) was applied to bilateral Hoku (LI-4) and Zusanli (ST-36) on 12 hrs and 36 hrs after induction of colitis. EA-treatment significantly reduced the macroscopic damage and the myeloperoxidase activity of colonic samples at 3 days post-induction of colitis. Colitic colon showed a decreased in vitro motility. However, colonic motility of EAtreated group was not significantly different from that of normal group. The anti-inflammatory effect of EA was not inhibited by a glucocorticoid receptor antagonist, RU-486, but suppressed by a beta-adrenoceptor antagonist, propranonol. These results suggest that EA-treatment has a beneficial effect on colitis, and its anti-inflammatory effect is mediated by beta-adrenoceptor activation but not by endogenous glucocorticoiddependent mechanism.
Keyword
MeSH Terms
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Acetic Acid
Adrenergic beta-Antagonists/pharmacology
Animals
Carbachol/pharmacology
Cholinergic Agonists/pharmacology
Colitis/chemically induced/enzymology/pathology/*therapy
Electroacupuncture/*veterinary
Enzyme Inhibitors/metabolism
Gastrointestinal Motility/physiology
Hormone Antagonists/pharmacology
Male
Mifepristone/pharmacology
Muscle Contraction/physiology
Muscle, Smooth/drug effects/physiology
NG-Nitroarginine Methyl Ester/pharmacology
Peroxidase/metabolism
Propranolol/pharmacology
Rats
Rats, Sprague-Dawley
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