- Pulmonary thromboembolism due to severe hyperhomocysteinemia associated with a methyltetrahydrofolate reductase mutation
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Cho KH, Jeong MH, Sim DS, Hong YJ, Kim JH, Ahn Y, Kang JC
- KMID: 1793229
- Korean J Intern Med.
- 2013 Jan;28(1):112-115.
- doi: 10.3904/kjim.2013.28.1.112
No abstract available. -
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- Influence of Methylenetetrahydrofolate Reductase C677T Polymorphism on the Risk of Lung Cancer and the Clinical Response to Platinum-Based Chemotherapy for Advanced Non-Small Cell Lung Cancer: An Updated Meta-Analysis
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Zhu N, Gong Y, He J, Xia J, Chen X
- KMID: 1798134
- Yonsei Med J.
- 2013 Nov;54(6):1384-1393.
- doi: 10.3349/ymj.2013.54.6.1384
PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) has been implicated in lung cancer risk and response to platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC). However, the results are controversial. We performed... -
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- MTHFR C677T Polymorphism as a Risk Factor for Vascular Calcification in Chronic Hemodialysis Patients
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Lee SY, Kim HY, Park KM, Lee SY, Hong SG, Kim HJ, Yang DH
- KMID: 2157890
- J Korean Med Sci.
- 2011 Mar;26(3):461-465.
- doi: 10.3346/jkms.2011.26.3.461
Polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T is one of the suggested risk factors for atherosclerosis. However, few studies have reported on the relationship between MTHFR C677T polymorphism and vascular calcification... -
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- Association of Methylenetetrahydrofolate Reductase (MTHFR 677C>T and 1298A>C) Polymorphisms and Haplotypes with Silent Brain Infarction and Homocysteine Levels in a Korean Population
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Han IB, Kim OJ, Ahn JY, Oh D, Hong SP, Huh R, Chung SS, Kim NK
- KMID: 1126027
- Yonsei Med J.
- 2010 Mar;51(2):253-260.
- doi: 10.3349/ymj.2010.51.2.253
PURPOSE: Methylenetetrahydrofolate reductase (MTHFR) is the main regulatory enzyme for homocysteine metabolism. In the present study, we evaluated whether the MTHFR 677C>T and 1298A>C gene polymorphisms are associated with SBI... -
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- The C677 Mutation in Methylene Tetrahydrofolate Reductase Gene: Correlation with Uric Acid and Cardiovascular Risk Factors in Elderly Korean men
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Hong YS, Lee MJ, Kim KH, Lee SH, Lee YH, Kim BG, Jeong B, Yoon HR, Nishio H, Kim JY
- KMID: 1733478
- J Korean Med Sci.
- 2004 Apr;19(2):209-213.
- doi: 10.3346/jkms.2004.19.2.209
The C677T mutation in the methylene tetrahydrofolate reductase (MTHFR) gene results in elevated homocysteine levels and, presumably, in increased cardiovascular risk. Moreover, elevated homocysteine levels are reportedly associated with high... -
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- Clinical Significance of Thymidylate Synthase and Methylenetetrahydrofolate Reductase Gene Polymorphism in Korean Patients with Gastric Cancer
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Lee J, Jeong CK, Hong SP, Chong SY, Oh D, Hwang SG, Ahn DH, Kim S, Han JH, Kim NK
- KMID: 1767507
- Korean J Gastroenterol.
- 2005 Jul;46(1):32-38.
BACKGROUND/AIMS: Thymidylate synthase (TS) is a target enzyme of 5-fluorouracil (5-FU) and has a polymorphic 28 bp tandem repeated sequence. TS enhancer region (TSER) polymorphism has been associated with the... -
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- Association between Methylenetetrahydrofolate Reductase C677T Polymorphism and Bone Mineral Density: The Dong-gu Study and the Namwon Study
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Shin MH, Choi JS, Rhee JA, Lee YH, Nam HS, Jeong SK, Park KS, Kim HY, Ryu SY, Choi SW, Song HR, Kim HN, Cauley JA, Kweon SS
- KMID: 2158051
- J Korean Med Sci.
- 2013 Jun;28(6):965-968.
- doi: 10.3346/jkms.2013.28.6.965
The purpose of this study was to examine the association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and bone mineral density (BMD). Two large cohort studies were performed: the Dong-gu... -
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- Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study
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Kweon SS, Lee YH, Jeong SK, Nam HS, Park KS, Choi SW, Kim BH, Kim HN, Choi JS, Shin MH
- KMID: 1786120
- J Korean Med Sci.
- 2014 May;29(5):743-747.
- doi: 10.3346/jkms.2014.29.5.743
The reference interval for plasma total homocysteine (tHcy) and serum folate concentrations were estimated. Total of 3,154 reference individuals (1,029 men and 2,125 women) were selected based on stringent exclusion... -
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- No Association of Functional Polymorphisms in Methlylenetetrahydrofolate Reductase and the Risk and Minor Physical Anomalies of Schizophrenia in Korean Population
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Kim SG, Song JY, Joo EJ, Jeong SH, Kim SH, Lee KY, Lee NY, Ahn YM, Kim YS, Roh MS
- KMID: 1785995
- J Korean Med Sci.
- 2011 Oct;26(10):1356-1363.
- doi: 10.3346/jkms.2011.26.10.1356
Methylenetetrahydrofolate reductase (MTHFR), a critical enzyme in folate metabolism, plays an important role in DNA methylation. It has been suggested that abnormal DNA methylation contributes to the pathogenesis of schizophrenia... -
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- Methylenetetrahydrofolate reductase polymorphism, diet, and breast cancer in Korean women
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Lee SA, Kang D, Nishio H, Lee MJ, Kim DH, Han W, Yoo KY, Ahn SH, Choe KJ, Hirvonen A, Noh DY
- KMID: 1380205
- Exp Mol Med.
- 2004 Apr;36(2):116-121.
To evaluate the interactive effect of methylenetetrahydrofolate reductase (MTHFR) genotype and dietary factors on the development of breast cancer, a hospital based case-control study was conducted in South Korean study... -
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