J Korean Med Sci.  2011 Mar;26(3):461-465. 10.3346/jkms.2011.26.3.461.

MTHFR C677T Polymorphism as a Risk Factor for Vascular Calcification in Chronic Hemodialysis Patients

• Lee SY
• Kim HY
• Park KM
• Lee SY
• Hong SG
• Kim HJ
• Yang DH

• KMID: 2157890
• DOI: http://doi.org/10.3346/jkms.2011.26.3.461

Abstract

Polymorphism of 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T is one of the suggested risk factors for atherosclerosis. However, few studies have reported on the relationship between MTHFR C677T polymorphism and vascular calcification (VC) in chronic hemodialysis patients. We investigated the relationship between the MTHFR C677T polymorphism and VC in 152 chronic hemodialysis patients. Patients with a TT genotype exhibited significantly higher VC scores than patients expressing CC and CT (P = 0.002). The prevalence of peripheral vascular disease increased with the incidence of MTHFR C677T mutations for all patients, and the incidence of cerebrovascular accidents also increased with the presence of mutations for young patients (< or = 60 yr) (P < 0.05). Patients with CT and TT genotypes had adjusted odds ratios for VC of 1.39 and 1.58, respectively (P < 0.05). In summary, these data suggest that the MTHFR C677T polymorphism affects the degree of VC in chronic hemodialysis patients.

Keyword

Methylenetetrahydrofolate Reductase (MTHFR); Renal Dialysis; Homocysteine; Vascular Calcification

MeSH Terms

Aged
Calcinosis/*genetics
Genetic Predisposition to Disease
Humans
Kidney Failure, Chronic/*genetics
Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
Middle Aged
*Polymorphism, Single Nucleotide
*Renal Dialysis
Risk Factors
Vascular Diseases/*genetics

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