J Korean Med Sci.  2013 Jun;28(6):965-968. 10.3346/jkms.2013.28.6.965.

Association between Methylenetetrahydrofolate Reductase C677T Polymorphism and Bone Mineral Density: The Dong-gu Study and the Namwon Study

• Shin MH
• Choi JS
• Rhee JA
• Lee YH
• Nam HS
• Jeong SK
• Park KS
• Kim HY
• Ryu SY
• Choi SW
• Song HR
• Kim HN
• Cauley JA
• Kweon SS

• KMID: 2158051
• DOI: http://doi.org/10.3346/jkms.2013.28.6.965

Abstract

The purpose of this study was to examine the association between the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and bone mineral density (BMD). Two large cohort studies were performed: the Dong-gu Study (3,621 men and 5,409 women) and the Namwon Study (3,703 men and 5,672 women). We assessed lumbar spine and femoral neck BMD by dual-energy X-ray absorptiometry. Genotypes were determined by real-time polymerase chain reaction. Multiple linear regression analysis was performed to evaluate the association between MTHFR C677T and BMD, adjusting for age, weight and height. The MTHFR C677T genotype frequencies for CC, CT, and TT genotypes were 34.5, 48.7, and 16.8%, respectively, in the Dong-gu Study and 33.6, 49.2, and 17.2%, respectively, in the Namwon Study. There are no significant differences between the MTHFR C677T genotype and the BMD at the lumbar spine and femoral neck in men or women in both cohorts.

Keyword

Bone Density; Methylenetetrahydrofolate Reductase; Polymorphism, Genetic

MeSH Terms

Absorptiometry, Photon
Aged
Alleles
*Bone Density
Cohort Studies
Female
Femur Neck/radiography
Gene Frequency
Genotype
Humans
Lumbar Vertebrae/radiography
Male
Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
Middle Aged
Polymorphism, Single Nucleotide
Methylenetetrahydrofolate Reductase (NADPH2)

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