J Korean Med Sci.  2014 May;29(5):743-747. 10.3346/jkms.2014.29.5.743.

Methylenetetrahydrofolate Reductase 677 Genotype-Specific Reference Values for Plasma Homocysteine and Serum Folate Concentrations in Korean Population Aged 45 to 74 Years: The Namwon Study

• Kweon SS
• Lee YH
• Jeong SK
• Nam HS
• Park KS
• Choi SW
• Kim BH
• Kim HN
• Choi JS
• Shin MH

• KMID: 1786120
• DOI: http://doi.org/10.3346/jkms.2014.29.5.743

Abstract

The reference interval for plasma total homocysteine (tHcy) and serum folate concentrations were estimated. Total of 3,154 reference individuals (1,029 men and 2,125 women) were selected based on stringent exclusion criteria. For plasma tHcy concentration (microM/L), reference values (median [5-95 percentile]) were 7.72 (5.03 to 13.80) and 6.09 (3.95-10.19) in men and women, respectively. For serum folate concentration (nM/L), reference values were 23.71 (11.73-38.44) and 28.95 (15.23-40.44) in men and women, respectively. The tHcy levels of both genders in the present study were lower than those in previous reports from other countries and Korea.

Keyword

Homocysteine; Folic Acid; Reference Intervals; Aged Population

MeSH Terms

Age Factors
Aged
Aging
Cohort Studies
Female
Folic Acid/*blood
Genotype
Homocysteine/*blood
Humans
Male
Methylenetetrahydrofolate Reductase (NADPH2)/*genetics
Middle Aged
Reference Values
Republic of Korea
Sex Factors
Folic Acid
Homocysteine
Methylenetetrahydrofolate Reductase (NADPH2)

Figure

• 

  Fig. 1 Percentile curves of plasma homocysteine and serum folate concentration by genders (n= 3,154).

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