- Heme Oxygenase-1 Induced by Aprotinin Inhibits Vascular Smooth Muscle Cell Proliferation Through Cell Cycle Arrest in Hypertensive Rats
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Choi HC, Lee KY, Lee DH, Kang YJ
- KMID: 2071686
- Korean J Physiol Pharmacol.
- 2009 Aug;13(4):309-313.
- doi: 10.4196/kjpp.2009.13.4.309
Spontaneous hypertensive rats (SHR) are an established model of genetic hypertension. Vascular smooth muscle cells (VSMC) from SHR proliferate faster than those of control rats (Wistar-Kyoto rats; WKY). We tested... -
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- Aprotinin Inhibits Vascular Smooth Muscle Cell Inflammation and Proliferation via Induction of HO-1
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Lee DH, Choi HC, Lee KY, Kang YJ
- KMID: 2071661
- Korean J Physiol Pharmacol.
- 2009 Apr;13(2):123-129.
- doi: 10.4196/kjpp.2009.13.2.123
Aprotinin is used clinically in cardiopulmonary bypass surgery to reduce transfusion requirements and the inflammatory response. The mechanism of action for the anti-inflammatory effects of aprotinin is still unclear.... -
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- Effect of quercetin on the production of nitric oxide in murine macrophages stimulated with lipopolysaccharide from Prevotella intermedia
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Cho YJ, Kim SJ
- KMID: 2027815
- J Periodontal Implant Sci.
- 2013 Aug;43(4):191-197.
- doi: 10.5051/jpis.2013.43.4.191
PURPOSE: Nitric oxide (NO) is a short-lived bioactive molecule that is known to play an important role in the pathogenesis of periodontal disease. In the current study, we investigated the... -
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- The Significance of Perfusion Defect at Myocardial Perfusion MR Imaging in a Cat Model of Acute Reperfused Myocardial Infarction
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Goo HW, Kim DH, Lee SS, Park SB, Lim TH
- KMID: 1118790
- Korean J Radiol.
- 2002 Dec;3(4):235-239.
- doi: 10.3348/kjr.2002.3.4.235
OBJECTIVE: To determine whether the size of a perfusion defect seen at myocardial perfusion MR imaging represents the extent of irreversibly damaged myocardium in acute reperfused myocardial infarction. MATERIALS AND... -
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- Evaluation by Contrast-Enhanced MR Imaging of the Lateral Border Zone in Reperfused Myocardial Infarction in a Cat Model
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Jeong AK, Choi SI, Kim DH, Park SB, Lee SS, Choi SH, Lim TH
- KMID: 754119
- Korean J Radiol.
- 2001 Mar;2(1):21-27.
- doi: 10.3348/kjr.2001.2.1.21
OBJECTIVE: To identify and evaluate the lateral border zone by comparing the size and distribution of the abnormal signal area demonstrated by MR imaging with the infarct area revealed by... -
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- Effects of Heme Oxygenase-1 Inducer and Inhibitor on Experimental Autoimmune Uveoretinitis
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Jang JU, Lee SH, Choi CU, Bahk SC, Chung HT, Yang YS
- KMID: 754643
- Korean J Ophthalmol.
- 2007 Dec;21(4):238-243.
- doi: 10.3341/kjo.2007.21.4.238
PURPOSE: Experimental autoimmune uveoretinitis (EAU) is an animal model of posterior uveitis and heme oxygenase-1 (HO-1) is a well-known anti-oxidant factor. However, there is no report a protective role... -
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- Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells
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Pae HO, Jeong GS, Jeong SO, Kim HS, Kim SA, Kim YC, Yoo SJ, Kim HD, Chung HT
- KMID: 1047077
- Exp Mol Med.
- 2007 Jun;39(3):267-277.
In vascular smooth muscle cells (VSMCs), induction of the heme oxygenase-1 (HO-1) confers vascular protection against cellular proliferation mainly via its up-regulation of the cyclin-dependent kinase inhibitor p21(WAF1/CIP1) that is... -
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