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Phagocytosis and Endocytosis of Silver Nanoparticles Induce Interleukin-8 Production in Human Macrophages

Kim S, Choi IH

Phagocytosis or endocytosis by macrophages is critical to the uptake of fine particles, including nanoparticles, in order to initiate toxic effects in cells. Here, our data enhance the understanding of...
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Exendin-4 improves resistance to Listeria monocytogenes infection in diabetic db/db mice

Liu HY, Chung CY, Yang WC, Liang CL, Wang CY, Chang CY, Chang CL

The incidence of diabetes mellitus is increasing among companion animals. This disease has similar characteristics in both humans and animals. Diabetes is frequently identified as an independent risk factor for...
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Protection of Phagocytic Macrophages from Peroxidative Damage by Selenium and Vitamin E

Oh SH, Lee MH, Chung CJ

The Protective effect of vitamin E and selenium against peroxidative damage in white blood cells was studied. Forty-eight male rats (~100g BW) were divided into four groups and were fed...
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Immunomodulatory effects of betulinic acid from the bark of white birch on mice

Yi JE, Obminska-Mrukowicz B, Yuan LY, Yuan H

The objective of this study was to explore the immunomodulatory effects of betulinic acid (BA) extracted from the bark of white birch on mice. Female mice were orally administered BA...
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Guanylyl cyclase C and guanylin reduce fat droplet accumulation in cattle mesenteric adipose tissue

Yasuda M, Kawabata J, Akieda-Asai S, Nasu T, Date Y

Guanylyl cyclase C (GC-C) is a member of a family of enzymes that metabolize GTP to cGMP and was first identified as a receptor for heat-stable enterotoxin. Guanylin (GNY) has...
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B-cell-activating factor is a regulator of adipokines and a possible mediator between adipocytes and macrophages

Kim MY, Kim DH, Do MS

  • KMID: 2154223
  • Exp Mol Med.
  • 2013 Jan;45(1):e4.
3T3-L1 adipocytes express the B-cell-activating factor (BAFF) and three different BAFF receptors (BAFF-Rs). Furthermore, BAFF expression is regulated by inflammatory modulators, such as tumor necrosis factor-alpha and rosiglitazone. Here we...
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Corn silk induces nitric oxide synthase in murine macrophages

Kim KA, Choi SK, Choi HS

  • KMID: 1103321
  • Exp Mol Med.
  • 2004 Dec;36(6):545-550.
Corn silk has been purified as an anticoagulant previously and the active component is a polysaccharide with a molecular mass of 135 kDa. It activates murine macrophages to induce nitric...
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Oxidation-dependent effects of oxidized LDL: proliferation or cell death

Han CY, Kim Pak YM

  • KMID: 1029922
  • Exp Mol Med.
  • 1999 Dec;31(4):165-173.
Oxidized low-density lipoprotein (oxLDL) induces a wide range of cellular responses to produce atherosclerotic lesion, but key factors determining the response are not understood. In this study, purified...
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Inhibitory effect of (-)-epigallocatechin gallate on titanium particle-induced TNF-alpha release and in vivo osteolysis

Jin S, Park JY, Hong JM, Kim TH, Shin HI, Park EK, Kim SY

Tumor necrosis factor-alpha (TNF-alpha) and inflammatory cytokines released from activated macrophages in response to particulate debris greatly impact periprosthetic bone loss and consequent implant failure. In the present study, we...
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Inhibitory effect of red ginseng acidic polysaccharide from Korean red ginseng on phagocytic activity and intracellular replication of Brucella abortus in RAW 264.7 cells

Bernardo Reyes AW, Simborio H, Hop HT, Arayan LT, Min WG, Lee HJ, Rhee MH, Chang HH, Kim S

Korean red ginseng (KRG) has long been used in traditional Korean and Oriental medicine. However, the anti-bacterial mechanism and therapeutic efficiency of KGR for intracellular Brucella infection are still unclear....
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Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice

Oh YB, Ahn M, Lee SM, Koh HW, Lee SH, Kim SH, Park BH

  • KMID: 2154242
  • Exp Mol Med.
  • 2013 May;45(5):e23.
Recent studies have documented that Janus-activated kinase (JAK)-signal transducer and activator of transcription (STAT) pathway can modulate the apoptotic program in a myocardial ischemia/reperfusion (I/R) model. To date, however, limited...
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Mesenchymal stem cells reciprocally regulate the M1/M2 balance in mouse bone marrow-derived macrophages

Cho DI, Kim MR, Jeong HY, Jeong HC, Jeong MH, Yoon SH, Kim YS, Ahn Y

Mesenchymal stem cells (MSCs) have been widely studied for their applications in stem cell-based regeneration. During myocardial infarction (MI), infiltrated macrophages have pivotal roles in inflammation, angiogenesis and cardiac remodeling....
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Reactive oxygen species regulate context-dependent inhibition of NFAT5 target genes

Kim NH, Hong BK, Choi SY, Moo Kwon H, Cho CS, Yi EC, Kim WU

  • KMID: 2154251
  • Exp Mol Med.
  • 2013 Jul;45(7):e32.
The activation of nuclear factor of activated T cells 5 (NFAT5), a well-known osmoprotective factor, can be induced by isotonic stimuli, such as activated Toll-like receptors (TLRs). It is unclear,...
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Antileishmanial and Cytotoxic Effects of Essential Oil and Methanolic Extract of Myrtus communis L.

Mahmoudvand H, Ezzatkhah , Sharififar F, Sharifi I, Dezaki ES

Plants used for traditional medicine contain a wide range of substances that can be used to treat various diseases such as infectious diseases. The present study was designed to evaluate...
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Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils

Jung YS, Lee HY, Kim SD, Park JS, Kim JK, Suh PG, Bae YS

  • KMID: 2154246
  • Exp Mol Med.
  • 2013 Jun;45(6):e27.
Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (beta-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils...
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Downstream components of RhoA required for signal pathway of superoxide formation during phagocytosis of serum opsonized zymosans in macrophages

Kim JS, Kim JG, Jeon CY, Won HY, Moon MY, Seo JY, Kim JI, Kim J, Lee JY, Choi SY, Park J, Yoon Park , Ha KS, Kim PH, Park JB

  • KMID: 1116203
  • Exp Mol Med.
  • 2005 Dec;37(6):575-587.
Rac1 and Rac2 are essential for the control of oxidative burst catalyzed by NADPH oxidase. It was also documented that Rho is associated with the superoxide burst reaction during phagocytosis...
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