- Virulent Treponema pallidum 47 kDa antigen regulates the expression of cell adhesion molecules and binding of T-lymphocytes to cultured human dermal microvascular endothelial cells
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Lee KH, Choi HJ, Lee MG, Lee JB
- KMID: 1062242
- Yonsei Med J.
- 2000 Oct;41(5):623-633.
- doi: 10.3349/ymj.2000.41.5.623
Perivasculitis and endothelial cell abnormalities are prominent histopathologic features of syphilis. Various cutaneous lesions are the main clinical features of syphilis. We examined whether Treponema pallidum 47 kDa antigen regulates... -
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- Protective mechanism of glucose against alloxan-induced beta-cell damage: pivotal role of ATP
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Rho HW, Lee JN, Kim HR, Park BH, Park JW
- KMID: 927128
- Exp Mol Med.
- 2000 Mar;32(1):12-17.
Glucose prevents the development of diabetes induced by alloxan. In the present study, the protective mechanism of glucose against alloxan-induced beta-cell damage was investigated using HIT-T 15 cell, a Syrian... -
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- Suppression of NF-kappaB activation in normal T cells by supernatant fluid from human renal cell carcinomas
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Kim HJ, Park JK, Kim YG
- KMID: 646309
- J Korean Med Sci.
- 1999 Jun;14(3):299-303.
- doi: 10.3346/jkms.1999.14.3.299
T lymphocytes from patients with renal cell carcinoma (RCC) show reduced immune function and impaired activation of the transcription factor, NF-kappaB. We determined the mechanism of NF-kappaB suppression in T... -
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- Colocalization of Interferon Regulatory Factor 7 (IRF7) with Latent Membrane Protein 1 (LMP1) of Epstein-Barr Virus
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Kim IW, Park HS
- KMID: 1778415
- J Korean Med Sci.
- 2006 Jun;21(3):379-384.
- doi: 10.3346/jkms.2006.21.3.379
Interferon regulatory factor 7 (IRF7) is one of the transcriptional factors for the activation of type I Interferon (IFN) genes. It is known that IRF7 and the latent membrane protein... -
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- First Male Case of Lymphocytic Hypophysitis in Korea
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Chung HK, Kim DH, Kim SJ, Park BJ, Kim EJ, Myong NH, Choi SJ
- KMID: 2157639
- J Korean Med Sci.
- 2003 Apr;18(2):290-294.
- doi: 10.3346/jkms.2003.18.2.290
Lymphocytic hypophysitis is a rare inflammatory disorder which is caused by autoimmune destruction of the pituitary gland. Almost all reported cases have been in women and the disease is often... -
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- Activation of monocytes, T-lymphocytes and plasma inflammatory markers in angina patients
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Lee WH, Lee Y, Kim JR, Chu JA, Lee SY, Jung JO, Kim JS, Kim S, Seo JD, Rhee SS, Park JE
- KMID: 755045
- Exp Mol Med.
- 1999 Sep;31(3):159-164.
Inflammation and activation of immune cells have important roles in the pathogenesis of atherosclerosis. We analyzed the plasma levels of inflammatory markers and the degree of activation of peripheral blood monocytes and T-lymphocytes... -
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- Nuclear factor of activated T cells negatively regulates expression of the tumor necrosis factor receptor-related 2 gene in T cells
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Kim WK, Sul OJ, Kwak JS, Hur HY, Latour AM, Koller BH, Kwon BS, Jeong CS
- KMID: 1115264
- Exp Mol Med.
- 2010 Dec;42(12):805-810.
- doi: 10.3858/emm.2010.42.12.083
Tumor necrosis factor receptor-related 2 (TR2, HVEM or TNFRSF-14) plays an important role in immune responses, however, the mechanisms regulating its expression are unclear. To understand the control of TR2... -
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- HIV-Specific Cellular Immune Responses Are Stimulated by Structured Treatment Interruption in Chronically HIV-1 Infected Koreans
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Choi JY, Song YG, Park YS, Yoon HJ, Kim MS, Kim YK, Shin SY, Kim JM
- KMID: 1110757
- Yonsei Med J.
- 2006 Apr;47(2):282-286.
- doi: 10.3349/ymj.2006.47.2.282
We evaluated the enhancing effect of structured treatment interruptions (STIs) on HIV-specific immunity in chronically HIV-1 infected Korean patients. A prospective case-control study was done with a total of 10... -
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- Impaired phosphorylation and mis-localization of Bub1 and BubR1 are responsible for the defective mitotic checkpoint function in Brca2-mutant thymic lymphomas
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Lee H
- KMID: 1093618
- Exp Mol Med.
- 2003 Oct;35(5):448-453.
Breast cancer susceptibility gene, BRCA2, is a tumor suppressor and individuals who inherit one defected copy of BRCA2 allele experience early onset breast cancer or ovarian cancer accompanied by the... -
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- Severe Chronic Active EBV Infection in an Adult Patient: Case Report
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Ha SY, Chung CW, Ko YH
- KMID: 1786827
- J Korean Med Sci.
- 2004 Jun;19(3):453-457.
- doi: 10.3346/jkms.2004.19.3.453
Severe chronic active Epstein-Barr virus (EBV) infection is a rare and life-threatening illness. Although the criteria for diagnosis include chronic or recurrent infectious mononucleosis-like symptoms lasting more than 6 months... -
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- The Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein, a toll-like receptor 4 agonist, enhances dendritic cell-based cancer vaccine potency
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Noh KT, Shin SJ, Son KH, Jung ID, Kang HK, Lee SJ, Lee EK, Shin YK, You JC, Park YM
- KMID: 1383795
- Exp Mol Med.
- 2012 May;44(5):340-349.
In this study, we showed the direct interaction between Mycobacterium avium subsp. paratuberculosis fibronectin attachment protein (FAP) and toll-like receptor4 (TLR4) via co-localization and binding by using confocal microscopy and... -
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- Bystander-Mediated Regression of Murine Neuroblastoma via Retroviral Transfer of the HSV-TK Gene
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Cho HS, Lee HR, Kim MK
- KMID: 1785703
- J Korean Med Sci.
- 2004 Feb;19(1):107-112.
- doi: 10.3346/jkms.2004.19.1.107
Selective introduction of genes conferring chemosensitivity into proliferating tumor cells may be used to treat cancer. We investigated the bystander effect of retrovirusmediated gene transfer of herpes simplex virus thymidine... -
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- Immunosuppression of xenograft rejection in porcine kidney PK15 cells by porcine IL-18
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Choi YS, Kim YK, Shim JH, Kim EM, Kang HS, Yoon DY, Muneta Y, Myung PK
- KMID: 1098092
- Exp Mol Med.
- 2006 Oct;38(5):574-582.
Xenotransplantation, the transplantation of cells, tissues or organs between individuals of different species, would resolve the current shortage of organs, but rejection remains the major hurdle to successful xenotransplantation. In... -
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- MRP8 promotes Th17 differentiation via upregulation of IL-6 production by fibroblast-like synoviocytes in rheumatoid arthritis
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Lee DG, Woo JW, Kwok SK, Cho ML, Park SH
- KMID: 2154239
- Exp Mol Med.
- 2013 Apr;45(4):e20.
Myeloid-related protein (MRP)8/MRP14 is an endogenous Toll-like receptor 4 (TLR4) ligand and is abundant in synovial fluid (SF) of rheumatoid arthritis (RA) patients. Belonging to damage-associated molecular patterns, it amplifies... -
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- The role of promoter methylation in Epstein-Barr virus (EBV) microRNA expression in EBV-infected B cell lines
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Kim DN, Song YJ, Lee SK
- KMID: 1015459
- Exp Mol Med.
- 2011 Jul;43(7):401-410.
- doi: 10.3858/emm.2011.43.7.044
Epstein-Barr virus (EBV) microRNAs (miRNAs) are expressed in EBV-associated tumors and cell lines, but the regulation mechanism of their expression is unclear yet. We investigated whether the expression of EBV... -
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- IL-17-deficient allogeneic bone marrow transplantation prevents the induction of collagen-induced arthritis in DBA/1J mice
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Park MJ, Park HS, Oh HJ, Lim JY, Yoon BY, Kim HY, Cho ML, Cho SG
- KMID: 1401761
- Exp Mol Med.
- 2012 Nov;44(11):694-705.
IL-17-producing CD4+ T cells (Th17) play important functions in autoimmune diseases and allograft rejection of solid organs. We examined the effects of IL 17 and its mechanism of action on... -
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- Primary Extranodal Marginal Zone B-cell Lymphoma of Mucosa-Associated Lymphoid Tissue-type in the Thymus of a Patient with Sjogren's Syndrome and Rheumatoid Arthritis
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Kim JM
- KMID: 1086752
- J Korean Med Sci.
- 2003 Dec;18(6):897-900.
- doi: 10.3346/jkms.2003.18.6.897
Primary thymic marginal zone B-cell lymphoma (MZBL) of mucosa-associated lymphoid tissue (MALT)-type is a very rare disease with distinct clinicopathologic features. I herein report a rare case of primary thymic... -
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- Decreased expression of DNA repair proteins Ku70 and Mre11 is associated with aging and may contribute to the cellular senescence
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Ju YJ, Lee KH, Park JE, Yi YS, Yun MY, Ham YH, Kim TJ, Choi HM, Han GJ, Lee JH, Lee J, Han JS, Lee KM, Park GH
- KMID: 1115947
- Exp Mol Med.
- 2006 Dec;38(6):686-693.
The gradual loss of telomeric DNA can contribute to replicative senescence and thus, having longer telomeric DNA is generally considered to provide a longer lifespan. Maintenance and stabilization of telomeric... -
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- Effects of anti-IgE mAb on serum IgE, Fc epsilon RII/CD23 expression on splenic B cells and worm burden in mice infected with Paragonimus westermani
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Shin MH, Min HK
- KMID: 1715336
- Korean J Parasitol.
- 1997 Mar;35(1):47-54.
- doi: 10.3347/kjp.1997.35.1.47
It is generally accepted that parasite-specific IgE plays a crucial role in host defense against helminthic parasites. However, the role of high levels of nonspecific IgE in helminthic infections is... -
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- Successful Renal Transplantation with Desensitization in Highly Sensitized Patients: A Single Center Experience
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Yoon HE, Hyoung BJ, Hwang HS, Lee SY, Jeon YJ, Song JC, Oh EJ, Park SC, Choi BS, Moon IS, Kim YS, Yang CW
- KMID: 1778155
- J Korean Med Sci.
- 2009 Jan;24(Suppl 1):S148-S155.
- doi: 10.3346/jkms.2009.24.S1.S148
Intravenous immunoglobulin (IVIG) and/or plasmapheresis (PP) are effective in preventing antibody-mediated rejection (AMR) of kidney allografts, but AMR is still a problem. This study reports our experience in living donor... -
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