Exp Mol Med.
2010 Dec;42(12):805-810. 10.3858/emm.2010.42.12.083.
Nuclear factor of activated T cells negatively regulates expression of the tumor necrosis factor receptor-related 2 gene in T cells
- Affiliations
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- 1Department of Biological Science and the Immunomodulation Research Center, University of Ulsan, Ulsan 680-749, Korea. csjeong@ulsan.ac.kr
- 2Department of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599-7248, USA.
- 3Division of Cell and Immunobiology and R&D Center for Cancer Therapeutics, National Cancer Center, Ilsan 410-769, Korea.
- KMID: 1115264
- DOI: http://doi.org/10.3858/emm.2010.42.12.083
Abstract
- Tumor necrosis factor receptor-related 2 (TR2, HVEM or TNFRSF-14) plays an important role in immune responses, however, the mechanisms regulating its expression are unclear. To understand the control of TR2 gene expression, we studied the upstream region of the gene. Gel supershift assays revealed inducible binding of nuclear factor of activated T cells (NFAT) to a putative NFAT site within the TR2 promoter. Furthermore, cotransfection of a dominant negative NFAT construct, or siRNA for NFAT, resulted in increased expression of a TR2 reporter gene. Our findings demonstrate that NFAT negatively regulates TR2 expression in activated T cells.
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