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Mechanisms of Alzheimer's Disease Pathogenesis and Prevention: The Brain, Neural Pathology, N-methyl-D-aspartate Receptors, Tau Protein and Other Risk Factors

Kocahan S, DoÄŸan Z

The characteristic features of Alzheimer's disease (AD) are the appearance of extracellular amyloid-beta (Aβ) plaques and neurofibrillary tangles in the intracellular environment, neuronal death and the loss of synapses, all...
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Safe Sedation and Hypnosis using Dexmedetomidine for Minimally Invasive Spine Surgery in a Prone Position

Kim KH

Dexmedetomidine, an imidazoline compound, is a highly selective alpha2-adrenoceptor agonist with sympatholytic, sedative, amnestic, and analgesic properties. In order to minimize the patients' pain and anxiety during minimally invasive spine...
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Alpha-Asarone, a Major Component of Acorus gramineus, Attenuates Corticosterone-Induced Anxiety-Like Behaviours via Modulating TrkB Signaling Process

Lee B, Sur B, Yeom M, Shim I, Lee H, Hahm DH

We investigated the anxiolytic-like activity of alpha-asarone (AAS) from Acorus gramineus in an experimental rat model of anxiety induced by repeated administration of the exogenous stress hormone corticosterone (CORT). The...
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Chronic Administration of Catechin Decreases Depression and Anxiety-Like Behaviors in a Rat Model Using Chronic Corticosterone Injections

Lee B, Sur B, Kwon S, Yeom M, Shim I, Lee H, Hahm DH

  • KMID: 2170678
  • Biomol Ther.
  • 2013 Jul;21(4):313-322.
Previous studies have demonstrated that repeated administration of the exogenous stress hormone corticosterone (CORT) induces dysregulation in the hypothalamic-pituitary-adrenal (HPA) axis and results in depression and anxiety. The current study...
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Alpha-Synuclein Expression in Patients with Parkinson's Disease: A Clinician's Perspective

Kim HJ

Although physiological function of alpha-synuclein is not yet clearly understood, accumulating evidence strongly suggests it plays a crucial role in the pathogenesis of Parkinson disease. Pathologically, alpha-synuclein is a major...
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Effect of Berberine on Depression- and Anxiety-Like Behaviors and Activation of the Noradrenergic System Induced by Development of Morphine Dependence in Rats

Lee B, Sur B, Yeom M, Shim I, Lee H, Hahm DH

The purpose of this study was to evaluate whether berberine (BER) administration could attenuate depression- and anxiety-like behaviors and increase corticotrophin-releasing factor (CRF) and tyrosine hydroxylase (TH) expression following chronic...
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Dexmedetomidine sedation in ICU

Yu SB

Dexmedetomidine (DEX), a highly selective alpha2-adrenergic receptor agonist, is the newest agent introduced for sedation in intensive care unit (ICU). The sedation strategy for critically ill patients has stressed light...
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Normal Sleep in Children and Adolescents

Nam SO

  • KMID: 1442105
  • J Korean Child Neurol Soc.
  • 2011 Aug;19(2):67-75.
Sleep is not just a rest for brain activity during daytime, but also has a vital function for memory consolidation after learning as well as restoration of both body and...
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Evaluation of recombinant adenovirus-mediated gene delivery for expression of tracer genes in catecholaminergic neurons

Kim ML, Han S, Lee SB, Kim JH, Ahn HK, Huh Y

Selective labeling of small populations of neurons of a given phenotype for conventional neuronal tracing is difficult because tracers can be taken up by all neurons at the injection site,...
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Is this Red Spot the Blue Spot (locus ceruleus)?

Choe W, Lee Y, Lee M, Hwang KH

  • KMID: 1709321
  • Nucl Med Mol Imaging.
  • 2010 Jun;44(2):157-158.
The authors report brain images of 18F-FDG-PET in a case of schizophrenia. The images showed strikingly increased bilateral uptake in the locus ceruleus. The locus ceruleus is called the blue...
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Neuroanatomy of Sleep-Wake Regulation and its Application to Pharmacotherapy

Kim HC

  • KMID: 2286720
  • Korean J Psychopharmacol.
  • 2007 May;18(3):133-142.
A current hypothesis of sleep-wake regulation proposes that the sleep process starts with the activation of sleep-promoting neurons located in the preoptic area of the anterior hypothalamus. This activation leads...
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Neuroimmunological Activation of Afferent Auditory Neural Circuit in LPS-Induced Otitis Media

Jun BC, Kim HT, Song CE, Lee DH, Yeo SW

  • KMID: 1977287
  • Korean J Otolaryngol-Head Neck Surg.
  • 2006 Oct;49(10):978-985.
BACKGROUND AND OBJECTIVES : The goal of this study was to identify the central modulation of the auditory pathway by peripheral inflammation and loud sound exposure, which is associated with...
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Effects of Phenylephrine on the Excitability of Medial Vestibular Nuclear Neurons in Rats

Jeong HS, Huh HR, Jang MJ, Hong SH, Jang S, Park J, Lee SH, Kim JH, Park JS

  • KMID: 2285323
  • Korean J Physiol Pharmacol.
  • 2006 Jun;10(3):131-135.
Coeruleo-vestibular pathway which connects locus coeruleus and vestibular nuclei is noradrenergic. This study was designed to elucidate the effects of phenylephrine on the spontaneous activity of acutely isolated medial vestibular...
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Analysis of Electrophysiological Change in the Rat LC Nucleus after Salicylic Acid Treatment

Kim SC, Kim SB, Park SY, Jun BH

  • KMID: 2276565
  • Korean J Otolaryngol-Head Neck Surg.
  • 2006 Feb;49(2):148-152.
BACKGROUND AND OBJECTIVES: The precise mechanism of salicylic acid induced tinnitus has not been clearly identified as yet in spite of wide range of studies undertaken. We looked for the...
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Effects of Chronic Alcohol Exposure on Dopaminergic and Serotonergic Neurotransmission System in Rat

Park SW, Lee YC, Ha EK, Kim YK, Lee YK, Chung DO, Ryu JW, Kong BG, Kim YH

  • KMID: 2287358
  • Korean J Psychopharmacol.
  • 2005 Jan;16(1):81-90.
OBJECTIVE: This study investigates the effects of chronic alcohol exposure on rat brain THmRNA expression, TH (tyrosine hydroxylase) acitivity, and TPH (tryptophan hydroxylase) activity which are important in synthesis of...
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In Vivo Microdialysis Measures of Extracellular Norepinephrine in the Rat Amygdala during Sleep-wakefulness

Park SP

Norepinephrine (NE)-containing locus ceruleus (LC) has been known to participate in the regulation of the sleep-wake cycle according to the differential firing rate. The aim of this study was to...
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C-fos Expression in Brain Stem of Rats after Salicylic Acid Treatment

Kim SC, Jun BH, Choi IS, Jung BJ, Kim DS

  • KMID: 2275882
  • Korean J Otolaryngol-Head Neck Surg.
  • 2002 Mar;45(3):214-218.
BACKGROUND AND OBJECTIVES: Subjective tinnitus, a distracting internal noise, is experienced by humans. Tinnitus is evoked by salicylic acid treatment in rats as confirmed by Jastreboff in 1994 in an...
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Neural Pathway Innervating Epididymis of Rats by Pseudorabies virus (PRV-Ba-Gal) and WGA-HRP

Lee CH, Ko BM, Lee BH, Chung OB

  • KMID: 1558429
  • Korean J Anat.
  • 2001 Apr;34(2):141-154.
This experimental studies was to investigate the location of PNS and CNS labeled neurons following injection of 2% WGA-HRP and pseudorabies virus (PRV), beta-galactosidase inserted Bartha strain, into the epididymis...
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The effects of chronic lead exposure on norepinephrinergic neurons of the nucleus locus ceruleus of the rat

Lee WT, Yoon H, Lee DJ, Lee JE, Koo CH, Park KA

  • KMID: 2224553
  • Korean J Anat.
  • 2000 Aug;33(4):423-432.
The neurotoxic effects of inorganic lead, a common environmental toxic substance, include peripheral neuropathy in adults and encephalopathy in children. Behavioral changes including hyperactivity, short attention span, easy distractibility and...
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Immunocytochemical Studies of Calbindin D-28k and Parvalbumin-Containing GABAergic Neurons in the Midbrain of the Cat

Kim JJ, Jeong SB, Kim NH, Ahn GH, Chung YY, Moon JS, Chang IY, Kim HS

  • KMID: 2071859
  • Korean J Phys Anthropol.
  • 2000 Jun;13(2):201-211.
This study was carried out to investigate the morphology, distribution and co-localization of calbindin D-28k and parvalbumin-containing GABAergic cells in the midbrain of the cat. The results obtain by immunocytochemical...
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