- Massive Identification of Cancer-Specific Nucleic Acid Ligands
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Lee YJ, Lee SW
- KMID: 1572640
- Genomics Inform.
- 2005 Jun;3(2):77-80.
Targeting of complex system such as human cells rather than biochemically pure molecules will be a useful approach to massively identify ligands specific for the markers associated with human disease... -
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- Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes
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Lee JW, Nam H, Yu SW
- KMID: 2354879
- Exp Neurobiol.
- 2016 Oct;25(5):262-268.
- doi: 10.5607/en.2016.25.5.262
Translocator protein 18 kDa (TSPO) is a mitochondrial protein highly expressed on reactive microglia and astrocytes, and is considered as a biomarker for neurodegeneration and brain damage, especially neuroinflammation. Toll-like... -
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- Characteristics in Molecular Vibrational Frequency Patterns between Agonists and Antagonists of Histamine Receptors
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Oh SJ
- KMID: 2166496
- Genomics Inform.
- 2012 Jun;10(2):128-132.
- doi: 10.5808/GI.2012.10.2.128
To learn the differences between the structure-activity relationship and molecular vibration-activity relationship in the ligand-receptor interaction of the histamine receptor, 47 ligands of the histamine receptor were analyzed by structural... -
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- Receptor for Advanced Glycation Endproducts (RAGE), Its Ligands, and Soluble RAGE: Potential Biomarkers for Diagnosis and Therapeutic Targets for Human Renal Diseases
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Lee EJ, Park JH
- KMID: 2166506
- Genomics Inform.
- 2013 Dec;11(4):224-229.
- doi: 10.5808/GI.2013.11.4.224
Receptor for advanced glycation endproducts (RAGE) is a multi-ligand receptor that is able to bind several different ligands, including advanced glycation endproducts, high-mobility group protein (B)1 (HMGB1), S-100 calcium-binding protein,... -
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- Inflammatory Receptors/Ligands as a Novel Target Against Obesity-Induced Inflammation and Metabolic Diseases
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Yu R
- KMID: 2271088
- Korean J Obes.
- 2014 Jun;23(2):83-90.
Obesity-induced inflammation is considered to be a potential cause of metabolic disorders such as insulin resistance, type 2 diabetes, and cardiovascular diseases. Various inflammatory components involved in obesity-induced inflammation are... -
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- Antifungal Activities of Biorelevant Complexes of Copper(II) with Biosensitive Macrocyclic Ligands
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Raman N, Joseph J, Velan AS, Pothiraj C
- KMID: 2312499
- Mycobiology.
- 2006 Dec;34(4):214-218.
Four copper(II) complexes have been prepared using macrocyclic ligands. The macrocyclic ligands have been synthesized by the condensation reaction of diethyl phthalate with Schiff bases derived from o-phenylene diamine and... -
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- Toll-Like Receptor Ligands as Cancer Immunotherapeutics
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Lee SE, Rhee JH
- KMID: 1434755
- J Bacteriol Virol.
- 2012 Sep;42(3):255-262.
- doi: 10.4167/jbv.2012.42.3.255
Toll-like receptors (TLRs) are pattern recognition receptors (PRRs) expressed in a wide spectrum of cell types that recognize distinctive ligands and subsequently activate adaptive immune responses. TLR ligands are considered... -
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- Scintillation Proximity Assay
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Choi CW
- KMID: 2038073
- Korean J Nucl Med.
- 1999 Dec;33(6):461-465.
Scintillation proximity assay (SPA) is a unique type of radioimmunoassay and makes it possible to use radioisotopes for monitoring binding reactions continuously without separation procedure. Microbeads containing a fluorophor are... -
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- Expression of TGF -beta I and II Ligands and Receptors at Epiphyseal Plate and Fracture Callus
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Lee KH, Lee YI, Cho KC, Oh IS, Lee JY, Kim SJ
- KMID: 2105308
- J Korean Orthop Assoc.
- 1998 Apr;33(2):458-465.
To understand the expression of hoth TGF-beta l and II ligands and the receptors, artificial fracture was made on rat femur. Fracture callus and epiphyseul plate were stained immunohistochemically on... -
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- Chimeric Antigen Receptor T Cell Therapy: A Novel Modality for Immune Modulation
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Yoon S, Eom GH
- KMID: 2468140
- Chonnam Med J.
- 2020 Jan;56(1):6-11.
- doi: 10.4068/cmj.2020.56.1.6
Cancer remains a leading cause of death, despite multimodal treatment approaches. Even in patients with a healthy immune response, cancer cells can escape the immune system during tumorigenesis. Cancer cells... -
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- Over-expression of EphrinA2 in the Anterior Region of the Developing Mouse Midbrain and Diencephalon
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Kim J, Park S
- KMID: 2224468
- Korean J Anat.
- 2006 Jun;39(3):177-186.
The Eph family is thought to exert its function through the complementary expression of receptors and ligands. The dorsal mesencephalon appears to be segmented into two broad regions demarcated by the... -
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- Brain-Region Specific Apoptosis Triggered by Eph/ephrin Signaling
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Park S
- KMID: 2165477
- Exp Neurobiol.
- 2013 Sep;22(3):143-148.
- doi: 10.5607/en.2013.22.3.143
Eph receptors and their ligands, ephrins, are abundantly expressed in neuroepithelial cells of the early embryonic brain. Overstimulation of Eph signaling in vivo increases apoptotic cell death of neuroepithelial cells,... -
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- Molecular Vibration-Activity Relationship in the Agonism of Adenosine Receptors
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Chee HK, Oh SJ
- KMID: 2166514
- Genomics Inform.
- 2013 Dec;11(4):282-288.
- doi: 10.5808/GI.2013.11.4.282
The molecular vibration-activity relationship in the receptor-ligand interaction of adenosine receptors was investigated by structure similarity, molecular vibration, and hierarchical clustering in a dataset of 46 ligands of adenosine receptors.... -
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- Glycobiology of Selectin
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Kim YS, Ko JH
- KMID: 2174908
- J Breast Cancer.
- 2005 Mar;8(1):4-16.
- doi: 10.4048/jbc.2005.8.1.4
Selectins, carbohydrate-binding molecules, bind to fucosylated and sialylated glycoprotein ligands, and are found on endothelial cells, leukocytes and platelets. They can be classified into E-, L- and P-selectins, and are... -
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- Innate Immunity and Organ Transplantation
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Yang CW
- KMID: 1512740
- Hanyang Med Rev.
- 2006 Aug;26(3):48-53.
The immune response of transplanted grafts has been considered to be within the realm of the adaptive immune system. Recently, with the discovery of the Toll-like receptors (TLRs), the role... -
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- Extracellular vesicles in renal physiology and clinical applications for renal disease
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Kwon SH
- KMID: 2448338
- Korean J Intern Med.
- 2019 May;34(3):470-479.
- doi: 10.3904/kjim.2019.108
Many cells in the nephron release extracellular vesicles (EVs). EVs envelop nucleic acids, proteins, and lipids. The surfaces of EVs express donor cell-specific markers, ligands, and major histocompatibility complex molecules.... -
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- The Serotonin-6 Receptor as a Novel Therapeutic Target
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Yun HM, Rhim H
- KMID: 1495345
- Exp Neurobiol.
- 2011 Dec;20(4):159-168.
- doi: 10.5607/en.2011.20.4.159
Serotonin (5-hydroxytryptamine, 5-HT) is an important neurotransmitter that is found in both the central and peripheral nervous systems. 5-HT mediates its diverse physiological responses through 7 different 5-HT receptor families:... -
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- Growth Factor-mediated Tumor Progression and Metastasis in Cholangiocarcinoma
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Kim DG
- KMID: 2448495
- Korean J Pancreas Biliary Tract.
- 2015 Oct;20(4):175-189.
- doi: 10.15279/kpba.2015.20.4.175
Different ligands can lead to the activation of epidermal growth factor receptor, and the subsequent signal transduction leads to an increase in cellular motility, proliferation, invasion, and blocking of apoptosis,... -
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- Evaluation of Advanced Structure-Based Virtual Screening Methods for Computer-Aided Drug Discovery
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Lee HS, Choi JW, Yoon SJ
- KMID: 2166251
- Genomics Inform.
- 2007 Mar;5(1):24-29.
Computational virtual screening has become an essential platform of drug discovery for the efficient identification of active candidates. Moleculardocking, a key technology of receptor-centric virtual screening, is commonly used to... -
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- Expression of Bombesin Family Ligands and Receptors in Human Gastric Cancer Tissues and Cell Lines
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Kim YH, Yang HK, Oh SK
- KMID: 2095963
- J Korean Surg Soc.
- 2002 Mar;62(3):198-204.
PURPOSE: Bombesin-like peptides are known to be important in the autocrine growth of a number of small cell lung cancer cell lines. The aim of this study was to investigate... -
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