- HIF-1alpha Upregulation due to Depletion of the Free Ubiquitin Pool
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Kim J, So D, Shin HW, Chun YS, Park JW
- KMID: 2344170
- J Korean Med Sci.
- 2015 Oct;30(10):1388-1395.
- doi: 10.3346/jkms.2015.30.10.1388
Hypoxia-inducible factor 1alpha (HIF-1alpha), which transactivates a variety of hypoxia-induced genes, is rapidly degraded under nomoxia through the hydroxylation-ubiquitination-proteasome pathway. In this study, we addressed how HIF-1alpha is stabilized by... -
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- The Macrophage-Specific Transcription Factor Can Be Modified Posttranslationally by Ubiquitination in the Lipopolysaccharide-Treated Macrophages
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Jung JW, Choi JC, Kim JY, Park IW, Choi BW, Shin JW, Christman
- KMID: 1442860
- Tuberc Respir Dis.
- 2011 Feb;70(2):113-124.
- doi: 10.4046/trd.2011.70.2.113
BACKGROUND: Macrophages are one of the most important inflammatory cells in innate immunity. PU.1 is a macrophage-specific transcription factor. Ubiquitins are the ultimate regulator of eukaryotic transcription. The ubiquitination process... -
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- Up-regulation of the DR5 Expression by Proteasome Inhibitor MG132 Augments TRAIL-Induced Apoptosis in Soft Tissue Sarcoma Cell Lines
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Cheong HJ, Lee KS, Woo IS, Won JH, Byun JH
- KMID: 2167538
- Cancer Res Treat.
- 2011 Jun;43(2):124-130.
PURPOSE: Current chemotherapeutics for treating locally advanced or metastatic soft tissue sarcomas (STS) are limited. Accordingly, the present in vitro study was conducted to evaluate the effects of treatment of... -
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- TNF-alpha-induced Increase of Human beta-defensin-2 Expression in HaCaT Cell Lines
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Park YD, Lee KS
- KMID: 2248097
- Korean J Dermatol.
- 2008 Jul;46(7):867-873.
BACKGROUND: Several kinds of epithelial cells and focal lymph nodes are known to be involved in the skin's immune reaction. Especially, internal antimicrobial peptide play an important role in protecting... -
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- The Proteasome Inhibitor MG132 Sensitizes Lung Cancer Cells to TRAIL-induced Apoptosis by Inhibiting NF-kappaB Activation
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Seo PW, Lee KY
- KMID: 2319129
- Tuberc Respir Dis.
- 2008 Dec;65(6):476-486.
BACKGROUND: TRAIL (TNF-related apoptosis inducing ligand) is a newly identified member of the TNF gene family which appears to have tumor-selective cytotoxicity due to the distinct decoy receptor system. TRAIL... -
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- Knockdown of Bcl-xL Enhances Growth-Inhibiting and Apoptosis-Inducing Effects of Resveratrol and Clofarabine in Malignant Mesothelioma H-2452 Cells
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Lee YJ, Hwang IS, Lee YJ, Lee CH, Kim SH, Nam HS, Choi YJ, Lee SH
- KMID: 2069926
- J Korean Med Sci.
- 2014 Nov;29(11):1464-1472.
- doi: 10.3346/jkms.2014.29.11.1464
Mcl-1 and Bcl-xL, key anti-apoptotic proteins of the Bcl-2 family, have attracted attention as important molecules in the cell survival and drug resistance. In this study, we investigated whether inhibition... -
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- The Comparison of Parathyroid Hormone Degradation Effect by Various Protease Inhibitors in Blood Specimen
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Kim YS, Kwon HJ, Lee HK
- KMID: 854965
- Korean J Lab Med.
- 2009 Apr;29(2):104-109.
- doi: 10.3343/kjlm.2009.29.2.104
BACKGROUND: The objective of this study was to evaluate the role of proteases on the degradation of parathyroid hormone (PTH) in blood samples. METHODS: Protease inhibitors with specificity against serine... -
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- House Dust Mite Induces Expression of Intercellular Adhesion Molecule-1 in EoL-1 Human Eosinophilic Leukemic Cells
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Kwon BC, Sohn MH, Kim KW, Kim ES, Kim KE, Shin MH
- KMID: 1713286
- J Korean Med Sci.
- 2007 Oct;22(5):815-819.
- doi: 10.3346/jkms.2007.22.5.815
The house dust mite (HDM) is considered to be the most common indoor allergen associated with bronchial asthma. In this study, we investigated whether crude extract of the HDM Dermatophagoides... -
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- Inhibition of NF-kappaB prevents high glucose-induced proliferation and plasminogen activator inhibitor-1 expression in vascular smooth muscle cells
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Jeong IK, Oh DH, Park SJ, Kang JH, Kim S, Lee MS, Kim MJ, Hwang YC, Ahn KJ, Chung HY, Chae MK, Yoo HJ
- KMID: 1058706
- Exp Mol Med.
- 2011 Dec;43(12):684-692.
- doi: 10.3858/emm.2011.43.12.079
Recent epidemiologic studies clearly showed that early intensive glucose control has a legacy effect for preventing diabetic macrovascular complications. However, the cellular and molecular processes by which high glucose leads... -
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