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Intra-renal slow cell-cycle cells contribute to the restoration of kidney tubules injured by ischemia/reperfusion

Kim J, Kim JI, Na YK, Park KM

Renal epithelial cells damaged by ischemia/reperfusion (I/R) can be restored by timely and appropriate treatment. Recent studies have reported that intra renal adult kidney stem cells contribute to the restoration...
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Ubiquitination of Aquaporin: in the kidney

Lee YJ, Kwon TH

Ubiquitination is known to be important for endocytosis and lysosomal degradation of aquaporin-2 (AQP2). Ubiquitin (Ub) is covalently attached to the lysine residue of the substrate proteins and activation and...
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Fluorescence Quenching to Measure dDAVP-induced Cell Volume Changes in Kidney Collecting Duct Cell

Choi HJ, Kwon TH

  • KMID: 2080003
  • Korean J Nephrol.
  • 2009 Jul;28(4):317-325.
PURPOSE: Cell volume regulation is critical in kidney collecting duct cells which are subjected to large transepithelial osmotic gradients and stimulation of vasopressin. The present study aimed at validating the...
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Biochemical Characteristics of The Na-alpha-Ketoglutarate Cotransport System in Proximal Convoluted and Straight Tubules of the Rabbit Kidney

Ahn DW, Kim KR, Park HS, Park YS

  • KMID: 2254125
  • Korean J Nephrol.
  • 2007 Jan;26(1):5-13.
PURPOSE: alpha-Ketoglutarate (alphaKG), a Krebs cycle intermediate, is extensively used in the kidney as a fuel substrate and as a counter anion for organic acid secretion. It is known to...
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Expression of Rh Glycoproteins in the Mammalian Kidney

Han KH, Kim HY, Weiner D

Ammonia metabolism is a fundamental process in the maintenance of life in all living organisms. Recent studies have identified ammonia transporter family proteins in yeast (Mep), plants (Amt), and mammals...
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TGF-beta Mediated Epithelial-Mesenchymal Transition in Autosomal Dominant Polycystic Kidney Disease

Chea SW, Lee KB

PURPOSE: Recent studies have showed that epithelial-mesenchymal transition (EMT) is a key process of glomerular and tubulointerstitial pathology in many chronic kidney diseases. However, there are no data of EMT...
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Mucinous Tubular and Spindle Cell Carcinoma of the Kidney: Touch Imprint Cytologic and Histologic Findings: A Case Report

Won KY, Kim GY, Lim SJ, Kim HC, Jeon SH

The recent WHO classification has recognized mucinous tubular and spindle cell carcinoma (MTSCC) as a distinct entity of renal cell carcinoma, exhibiting a mixed pattern of tubules and a surrounding...
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A Case of Low-Grade Tubular-Mucinous Renal Neoplasm (LGTMRN)

Cho KS, Han KS, Im YJ, Joo JM, Cho NH, Choi YD

  • KMID: 2293517
  • Korean J Urol.
  • 2004 Aug;45(8):837-840.
A low-grade tubular-mucinous renal neoplasm (LGTMRN) is a recently established renal tumor, which was thought to be of collecting duct origin. A 43-year-old man presented with acute abdominal pain and...
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Renal Handling of Ammonium and Acid Base Regulation

Kim HY

Renal ammonium metabolism is the primary component of net acid excretion and thereby is critical for acid - base homeostasis. Briefly, ammonium is produced from glutamine in the proximal tubule...
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New insights into the transcriptional regulation of aquaporin-2 and the treatment of X-linked hereditary nephrogenic diabetes insipidus

Jung HJ, Kwon TH

The kidney collecting duct (CD) is a tubular segment of the kidney where the osmolality and final flow rate of urine are established, enabling urine concentration and body water homeostasis....
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Drug-induced nephrotoxicity

Bae E, Lee TW, Park DJ

Drugs are a common cause of acute and chronic kidney disease and contribute to patient morbidity and increased healthcare utilization. Drug-induced nephrotoxicity is approximately 14% to 26% in adults and...
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Immunolocalization of anion exchanger 1 (Band 3) in the renal collecting duct of the common marmoset

Song JH, Kim YH, Kang TC, Won MH, Suh JG, Hyun BH, Oh YS, Ryu SY, Jung JY

The purpose of this study was to determine the expression and distribution of band 3 in the collecting duct and connecting tubules of the kidney of the marmoset monkey (Callithrix...
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A Case of Tenofovir-associated Fanconi Syndrome in Patient with Chronic Hepatitis B

Kim D, Lee J, Kim DH, Kang K, Suh SJ, Jung YK, Yim HJ

Tenofovir disoproxil fumarate (TDF) is one of the most widely used treatment options for human immunodeficiency virus (HIV) and HBV infections. Despite its efficacy and safety, some cases of nephrotoxicity...
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Dexamethasone enhances phospholipase D activity in M-1 cells

Kim WJ, Lee MJ, Park MA, Jung JS, Uhlinger D, Kwak JY

  • KMID: 755082
  • Exp Mol Med.
  • 2000 Sep;32(3):170-177.
Phospholipase D (PLD) is an enzyme involved in signal transduction and widely distributed in mammalian cells. The signal transduction pathways and role for phospholipid metabolism during hormonal response in...
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A squamous cell carcinoma of the renal pelvis with special reference to pathogenesis

Oh DB, Han CH, Lee JM, Wang CS, Park CI, Bae BS, Lee YW

  • KMID: 1677347
  • Korean J Urol.
  • 1970 Dec;11(4):245-250.
A case of squamous cell carcinoma arising in the renal pelvis is reported in view of its rarity. The patient was 57 year old male who bad complained of epigastric...
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Adefovir-induced Fanconi syndrome associated with osteomalacia

Park S, Kim WI, Cho DH, Kim YJ, Kim HS, Kim JH, Cha SK, Park KS, Lee JH, Lee SM, Lee EY

Fanconi syndrome is a dysfunction of the proximal renal tubules that results in impaired reabsorption and increased urinary loss of phosphate and other solutes. The pathophysiology of drug-induced Fanconi syndrome...
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Effects of Human Adipose-Derived Stem Cells in Regenerating the Damaged Renal Tubular Epithelial Cells in an Animal Model of Cisplatin-Induced Acute Kidney Injury

Kim S, Lee EB, Song IH, Kim YJ, Park H, Kim YW, Han GD, Kim KG, Park YH

BACKGROUND: We conducted this experimental study to examine whether human adipose-derived stem cells (ADSCs) are effective in achieving a recovery of damaged renal tubular epithelial cells in an animal model...
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Increased Expression of Heat Shock Protein 72 Protects Renal Proximal Tubular Cells from Gentamicin-induced Injury

Wang Z, Liu L, Mei Q, Liu L, Ran Y, Zhang R

The nephrotoxicity of gentamicin (GM) has been widely recognized. Heat shock protein 72 (HSP72) has been reported to be a cytoprotectant. However, its cytoprotective effect against GM induced kidney injury...
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Tenofovir-associated nephrotoxicity in patients with chronic hepatitis B: two cases

Cho H, Cho Y, Cho EJ, Lee JH, Yu SJ, Oh KH, Lee K, Mustika S, Yoon JH, Kim YJ

Tenofovir disoproxil fumarate (TDF) is effective against chronic hepatitis B (CHB) infection and its use is increasing rapidly worldwide. However, it has been established that TDF is associated with renal...
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Gentamicin Induced Apoptosis of Renal Tubular Epithelial (LLC-PK1) Cells

Choi KH, Kim TI, Chong DL, Lee HY, Han DS

  • KMID: 759521
  • Korean J Intern Med.
  • 2000 Dec;15(3):218-223.
Nephrotoxicity is a major limiting factor in the use of aminoglycoside antibiotics, the mechanisms for which are still speculative. To clarify the mechanisms of renal tubular cell death induced by...
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