- Retro- and Ante-grade Amnesia after Conscious Sedation Using Midazolam
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Kim YW, Keum YS, Mo DY, Lee JY, Kim HC, Lee SC
- KMID: 2425213
- J Korean Dent Soc Anesthesiol.
- 2011 Dec;11(2):153-158.
- doi: 10.17245/jkdsa.2011.11.2.153
Midazolam is known to produce sedation as well as amnesia. Many articles reported about anterograde amnesia, but it is rare that articles about retrograde amnesia. The 61-year-old female patient (64... -
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- Ethanol Extract of Chaenomeles sinensis Inhibits the Development of Benign Prostatic Hyperplasia by Exhibiting Anti-oxidant and Anti-inflammatory Effects
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Kang JS, Zhao XY, Lee JH, Lee JS, Keum YS
- KMID: 2528088
- J Cancer Prev.
- 2022 Mar;27(1):42-49.
- doi: 10.15430/JCP.2022.27.1.42
Chaenomeles sinensis is known to inhibit the development and progression of many age-related diseases, but the underlying molecular mechanisms are largely unclear. In the present study, we observed that the... -
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- Sensitization of 5-Fluorouracil-Resistant SNUC5 Colon Cancer Cells to Apoptosis by α-Mangostin
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Lee J, Kang JS, Choi BY, Keum YS
- KMID: 2374614
- Biomol Ther.
- 2016 Nov;24(6):604-609.
- doi: 10.4062/biomolther.2016.028
5-fluorouracil (5-FU) is a chemotherapeutic agent commonly used for treatment of solid tumors, including colorectal cancer. However, chemoresistance against 5-fluorouracil (5-FU) often limits its success for chemotherapy and, therefore, finding... -
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- Identification of a New Selective Chemical Inhibitor of Mutant Isocitrate Dehydrogenase-1
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Kim HJ, Choi BY, Keum YS
- KMID: 2171321
- J Cancer Prev.
- 2015 Mar;20(1):78-83.
- doi: 10.15430/JCP.2015.20.1.78
BACKGROUND: Recent genome-wide sequencing studies have identified unexpected genetic alterations in cancer. In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed... -
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- 4′-O-β-D-Glucosyl-5-O-Methylvisamminol Attenuates Pro-Inflammatory Responses and Protects against Oxidative Damages
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Yoo OK, Keum YS
- KMID: 2455093
- Biomol Ther.
- 2019 Jul;27(4):381-385.
- doi: 10.4062/biomolther.2018.232
We attempted to examine anti-inflammatory and anti-oxidant effects of 4′-O-β-D-glucosyl-5-O-methylvisamminol (GOMV), the first epigenetic inhibitor of histone phosphorylation at Ser10. While GOMV did not affect the viability of murine macrophage... -
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- Protective Effect of Fisetin (3,7,3',4'-Tetrahydroxyflavone) against gamma-Irradiation-Induced Oxidative Stress and Cell Damage
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Piao MJ, Kim KC, Chae S, Keum YS, Kim HS, Hyun JW
- KMID: 1502489
- Biomol Ther.
- 2013 May;21(3):210-215.
Ionizing radiation can induce cellular oxidative stress through the generation of reactive oxygen species, resulting in cell damage and cell death. The aim of this study was to determine whether... -
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- Oral Bisphosphonates Induced Osteonecrosis of the Mandible : a Case Report
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Son HJ, Jang HY, Keum YS, Lee JY, Kim HC, Lee SC
- KMID: 2328434
- J Korean Assoc Oral Maxillofac Surg.
- 2009 Apr;35(2):106-111.
Bisphosphonates have been approved for Paget's disease, cancer - related hypercalcemia, bone involvement in multiple myeloma or solid tumors and osteoporosis. Although, underlying pathophysiological mechanisms remain unclear, it seems that bisphosphonates... -
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- Effect of Thymol and Linalool Fumigation on Postharvest Diseases of Table Grapes
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Shin MH, Kim JH, Choi HW, Keum YS, Chun SC
- KMID: 2312756
- Mycobiology.
- 2014 Sep;42(3):262-268.
- doi: 10.5941/MYCO.2014.42.3.262
Several postharvest diseases of table grapes (Vitis vinifera) occur during storage, and gray mold rot is a particularly severe disease because the causal agent, Botrytis cinerea, grows at temperatures as... -
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- The Major Postharvest Disease of Onion and Its Control with Thymol Fumigation During Low-Temperature Storage
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Ji SH, Kim TK, Keum YS, Chun SC
- KMID: 2427105
- Mycobiology.
- 2018 Sep;46(3):242-253.
- doi: 10.1080/12298093.2018.1505245
Onion (Allium cepa L.) is one of the major vegetable crops in Korea that are damaged and lost by pathogenic fungal infection during storage due to a lack of proper... -
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- Finasteride Increases the Expression of Hemoxygenase-1 (HO-1) and NF-E2-Related Factor-2 (Nrf2) Proteins in PC-3 Cells: Implication of Finasteride-Mediated High-Grade Prostate Tumor Occurrence
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Yun DK, Lee J, Keum YS
- KMID: 2170685
- Biomol Ther.
- 2013 Jan;21(1):49-53.
A number of naturally-occurring or synthetic chemicals have been reported to exhibit prostate chemopreventive effects. Synthetic 5alpha-reductase (5-AR) inhibitors, e.g. finasteride and durasteride, gained special interests as possible prostate chemopreventive... -
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- Transcriptional Regulation of Hepatic Stellate Cell Activation by siRNA for TGF-beta1
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Oh HK, Kim KH, Keum YS, Cho CH, Park JB, Park KK
- KMID: 1472634
- Korean J Pathol.
- 2009 Dec;43(6):503-508.
- doi: 10.4132/KoreanJPathol.2009.43.6.503
BACKGROUND: The cytokine-induced activation of hepatic stellate cells (HSC) plays a major role in liver fibrosis. Quiescent HSCs undergo phenotypic transformation called "transdifferentiation" in response to viral, chemical or immune... -
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- Resveratrol Inhibits IL-6-Induced Transcriptional Activity of AR and STAT3 in Human Prostate Cancer LNCaP-FGC Cells
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Lee MH, Kundu JK, Keum YS, Cho YY, Surh YJ, Choi BY
- KMID: 2380320
- Biomol Ther.
- 2014 Sep;22(5):426-430.
- doi: 10.4062/biomolther.2014.061
Prostate cancer is the most frequently diagnosed cancer. Although prostate tumors respond to androgen ablation therapy at an early stage, they often acquire the potential of androgen-independent growth. Elevated transcriptional... -
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- Molecular Mechanisms Underlying Anti-Tumor Promoting Activities of Heat-Processed Panax ginseng C.A. Meyer
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Surh YJ, Na HK, Lee JY, Keum YS
- KMID: 1721173
- J Korean Med Sci.
- 2001 Dec;16(Suppl):S38-S41.
- doi: 10.3346/jkms.2001.16.S.S38
Recently, there have been considerable efforts to search for naturally occurring substances that can inhibit, reverse, or retard the multi-stage carcinogenesis. A wide array of phenolic substances derived from edible... -
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- The Effect of Ring-type NF-kappa B(NF-kB) Decoy Oligodeoxynucleotide on the Kidney for an Experimental Unilateral Ureteral Obstruction in Mice
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Kwon YG, Lee YG, Kang I, Lee ES, Park KK, Keum YS, Kim KH, Park JS
- KMID: 2061275
- Korean J Urol.
- 2007 Aug;48(8):815-825.
- doi: 10.4111/kju.2007.48.8.815
PURPOSE: The transcription factor, NF-kB, is important in the coordinated expressions of various pro-inflammatory and adhesion molecules. Our hypothesis is that inhibiting the action of NF-kB using a synthetic decoy... -
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- Fucoxanthin Protects Cultured Human Keratinocytes against Oxidative Stress by Blocking Free Radicals and Inhibiting Apoptosis
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Zheng J, Piao MJ, Keum YS, Kim HS, Hyun JW
- KMID: 2170672
- Biomol Ther.
- 2013 Jul;21(4):270-276.
Fucoxanthin is an important carotenoid derived from edible brown seaweeds and is used in indigenous herbal medicines. The aim of the present study was to examine the cytoprotective effects of... -
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- Ethanol Extract of Cirsium japonicum var. ussuriense Kitamura Exhibits the Activation of Nuclear Factor Erythroid 2-Related Factor 2-dependent Antioxidant Response Element and Protects Human Keratinocyte HaCaT Cells Against Oxidative DNA Damage
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Yoo OK, Choi BY, Park JO, Lee JW, Park BK, Joo CG, Heo HJ, Keum YS
- KMID: 2161526
- J Cancer Prev.
- 2016 Mar;21(1):66-72.
- doi: 10.15430/JCP.2016.21.1.66
Keratinocytes are constantly exposed to extracellular insults, such as ultraviolet B, toxic chemicals and mechanical stress, all of which can facilitate the aging of keratinocytes via the generation of intracellular... -
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