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Evaluation of the Stabilization of Human Umbilical Cord Blood-Derived Mast Cells in Accordance with Ketotifen and Olopatadine Concentration

Chun JW, Koh JW

PURPOSE: To evaluate the effect of olopatadine and ketotifen to stabilize mast cells using human umbilical cord blood-derived mast cells (hCBMCs). METHODS: Using cultured hCBMCs, we divided the cells into the...
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Clincal Effect of Ketotifen in Allergic Rhinitis

Eun SJ, Kim YD, Park MH, Suh JS, Song KW

Ketotifen, a benzocycloheptathiophene, has an orally effective antiallergic as well as antihistaminic properties. In pervious studies, Ketotifen has shown encouraging results on patient with allergic rhinitis, either perennial or seasonal. 39 patients...
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Effects of Ketotifen on an Experimental Model of IgA Nephropathy

Do YS, Soon EJ, Namgoong M

  • KMID: 2322100
  • J Korean Soc Pediatr Nephrol.
  • 2009 Oct;13(2):153-160.
PURPOSE: The intestinal mucosal defect has been known as one of the pathogenicmechanisms of IgA nephropathy. Oral antigens usually induce the activation of Th2 cells and mast cells. These cells...
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Wheat-dependent, Exercise-induced Anaphylaxis: A Successful Case of Prevention with Ketotifen

Choi JH, Lee HB, Ahn IS, Park CW, Lee CH

Food-dependent, exercise-induced anaphylaxis (FDEIA) is the triggering of anaphylaxis after ingestion of certain foods when followed by physical exercise. Symptoms vary from the typical generalized urticaria to severe allergic reactions....
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Inhibitory Effect of Disosium Cromoglycate and Ketotifen on Human Seminal Plasma-Induced Mast Cell Activation

Chai OH

BACKGROUND: Human seminal plasma (HSP)-induced hypersensitivity is one of the serious complications with sexual intercourse. The clinical manifestations of HSP-induced hypersensitivity may be related to the release of vasoactive mediators...
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Novel Suppressive Effects of Ketotifen on Migration and Invasion of MDA-MB-231 and HT-1080 Cancer Cells

Kim HJ, Park MK, Kim SY, Lee CH

The high mortality rates associated with cancer reflect the metastatic spread of tumor cells from the site of their origin. Metastasis, in fact, is the cause of 90% of cancer...
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Periorbital Allergic Contact Dermatitis to Ketotifen Fumarate Eyedrops

Choi WJ, Jue MS, Ro YS

  • KMID: 2301810
  • Korean J Dermatol.
  • 2010 Nov;48(11):989-992.
Ketotifen fumarate (KF) is a widely used drug for prophylaxis and the treatment of allergic conditions. Adverse cutaneous reactions to KF are rare except for dryness of the skin and...
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A case of solar urticaria in a young child

Kim EH, Kang H, Cho SH, Park YM

  • KMID: 2286062
  • J Asthma Allergy Clin Immunol.
  • 1999 Jun;19(3):509-513.
Solar urticaria is a rare disorder in which immediate erythema and wheals are induced by ultraviolet or visible irradiation. This condition usually occurs in the third and fifth decades of...
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A Case of Pressure Urticaria Treated with a Leukotriene Inhibitor

Lee YW, Kang MH, Seung NR, Park EJ, Kim CW, Kim KH, Kim KJ

  • KMID: 2247901
  • Korean J Dermatol.
  • 2009 May;47(5):588-591.
Delayed pressure urticria is a type of physical urticaria, characterized by the appearance of painful swelling for a few hours after physical stimulus. A 27-year-old woman suffered from pressure urticaria...
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A case of idiopathic anaphylaxis

Lee JK, Kim SH, Lim YJ, Park JK, Kim C, Cho YS, Yoo B, Moon HB

  • KMID: 1543171
  • Korean J Allergy.
  • 1997 Jun;17(2):192-197.
Idiopathic anaphylaxis is a life-threatening systemic reaction of unknown cause. The pathophysiology has not been established, although it has been postulated that the clinical manifestations of idiopathic anaphylaxis may result...
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Endotoxin-induced acute lung injury is mediated by PAF produced via remodelling of lyso PAF in the lungs

Lee YM, Kim T

  • KMID: 1580808
  • Korean J Physiol Pharmacol.
  • 2000 Jun;4(3):219-226.
In order to elucidate the role of platelet activating factor (PAF) in the acute lung injury induced by endotoxin (ETX), activities of phospholipase A2, lyso PAF acetyltransferase and oxidative stress by neutrophilic respiratory...
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Bepotastine-induced urticaria, cross-reactive with other antihistamines

Kang JW, Lee J

Second-generation antihistamines are widely prescribed for the control of symptoms of allergic inflammation such as itchy hives, coryza, and itchy eyes. In rare circumstances, these drugs might provoke allergic inflammation....
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A Case of Eosinophilic Gastroenteritis Diagnosed by Repeated Abdominal Pain with Eosinophilic Ascites and Cystitis

Lee SI, Park HS, Ha BK, Kim DH, Yoo JT, Choi SH

  • KMID: 1993600
  • Kosin Med J.
  • 2011 Dec;26(2):191-195.
Eosinophilic gastroenteritis is a relatively uncommondisease of unknown etiology and pathogensis. It is characterized by massive tissue eosinophilia, that can involve any layers of the gastrointestinal tract wall. The gastrointestinal...
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Aquagenic Urticaria: A Report of Two Cases

Park H, Kim HS, Yoo DS, Kim JW, Kim CW, Kim SS, Hwang JI, Lee JY, Choi YJ

Aquagenic urticaria is a rare form of physical urticaria, in which contact with water evokes wheals. A 19-year-old man and a 4-year-old boy complained of recurrent episodes of urticaria. Urticaria...
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Drug eruption by antihistamine mistaken for chronic urticaria in a child

Lee GM, Chu SY, Kang SY, Kim HB, Park JS, Kim JK

Although rare, antihistamines can cause adverse effects, including drug-induced eruptions or anaphylaxis. A 4-year-old child visited the pediatric department of a hospital for skin eruptions after administration of antihistamines, (e.g.,...
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Effect of the inhibition of PLA2 and PAF on the neutrophilic respiratory burst and apoptosis

Lee YM, Kim SG, Park YY

BACKGROUND: Since the exact pathogenesis of sepsis-induced ARDS has not been elucidated, the mechanisms of enhanced neutrophilic respiratory burst were probed in endotoxin primed neutrophils associated with the roles of...
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Protective Effect of the Inhibition of PAF Remodeling and Adhesion Molecule on the Oxidative Stress of the Lungs of Rats Given Endotoxin Intratracheally

Shin TR, Na BK, Lee YM

BACKGROUND: There have been many reports on the pathogenesis of sepsis-induced acute respiratory distress syndrome(ARDS) but, the precise mechanism has not been elucidated. This study examined the protective effect of...
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Successful Remission of Recurrent Anaphylaxis after Omalizumab Administration in a Patient with Systemic Mastocytosis

Moon H, Jang HJ, Lee CG, Kim YC, Yoo SH, Lee DS, Kang HR

Mastocytosis is a disorder characterized by abnormal mast cell proliferation and accumulation in one or more tissues. It presents in two major variants: cutaneous mastocytosis and systemic mastocytosis. Because the...
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A Case of Chronic Urticaria Presenting with Double Primary Malignancies in the Stomach and the Colon

  • KMID: 2299567
  • Korean J Asthma Allergy Clin Immunol.
  • 2009 Sep;29(3):208-211.
Chronic urticaria is a common disabling skin condition. Neoplasm has been case-reported as a comorbid disease with urticaria, although there is no reliable evidence suggesting a strong association between these...
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A Survey of Current Trend in the Management of Childhood Asthma in Practical Fields

Yoon HS, Cha JK, Lee HR

  • KMID: 2314175
  • Pediatr Allergy Respir Dis.
  • 1998 Sep;8(2):167-178.
PURPOSE: During the past two decades in Korea, the prevalence rate of childhood asthma has been increased, and also there has been a significant evolution in the management of asthma....
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