Ann Dermatol.  2009 May;21(2):203-205. 10.5021/ad.2009.21.2.203.

Wheat-dependent, Exercise-induced Anaphylaxis: A Successful Case of Prevention with Ketotifen

• Choi JH
• Lee HB
• Ahn IS
• Park CW
• Lee CH

• KMID: 2219398
• DOI: http://doi.org/10.5021/ad.2009.21.2.203

Abstract

Food-dependent, exercise-induced anaphylaxis (FDEIA) is the triggering of anaphylaxis after ingestion of certain foods when followed by physical exercise. Symptoms vary from the typical generalized urticaria to severe allergic reactions. We report the case of a 20-year-old woman who had a 7-year history of recurrent wheals and dyspnea after ingesting several kinds of food (wheat, pork, and beef) along with physical exercise. Based on a provocation test, she was diagnosed with wheat-dependent, exercise-induced anaphylaxis. She was instructed to take 2 mg of ketotifen 2 hours before ingestion of wheat to prevent the symptoms, and subsequently the provocation test did not elicit wheals. We therefore prescribed ketotifen (1 mg twice a day). She has not had recurrent wheals or dyspnea for 6 months. We herein report an interesting case of wheat-dependent, exercise-induced anaphylaxis with successful prevention by ketotifen.

Keyword

Food-dependent; exercise-induced anaphylaxis (FDEIA); Ketotifen; Wheat

MeSH Terms

Anaphylaxis
Dyspnea
Eating
Exercise
Female
Humans
Hypersensitivity
Ketotifen
Triticum
Urticaria
Young Adult
Ketotifen