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Histamine-Releasing Factor and Immunoglobulins in Asthma and Allergy

Kawakami T, Kashiwakura JI, Kawakami Y

Factors that can induce the release of histamine from basophils have been studied for more than 30 years. A protein termed histamine-releasing factor (HRF) was purified and molecularly cloned in...
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Most Highly Cytokinergic IgEs Have Polyreactivity to Autoantigens

Kashiwakura Ji, Okayama Y, Furue M, Kabashima , Shimada S, Ra C, Siraganian RP, Kawakami Y, Kawakami T

PURPOSE: Monomeric IgE molecules, when bound to the high-affinity receptor, exhibit a vast heterogeneity in their ability to induce survival promotion and cytokine production in mast cells. At one end...
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Capability of Radial- and Convex-Arrayed Echoendoscopes for Visualization of the Pancreatobiliary Junction

Kanno Y, Ito K, Koshita S, Ogawa T, Kusunose H, Masu K, Sakai T, Murabayashi T, Hasegawa S, Kozakai F, Kawakami Y, Fujii Y, Noda Y

BACKGROUND/AIMS: Although both radial- and convex-arrayed endoscopic ultrasonography (EUS) scopes are widely used for observational EUS examinations, there have been few comparative studies on their power of visualization. The aim...
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Mapping Drug Terms via Integration of a Retrieval-Augmented Generation Algorithm with a Large Language Model

Kimura E, Kawakami Y, Inoue S, Okajima A

Objectives: This study evaluated the efficacy of integrating a retrieval-augmented generation (RAG) model and a large language model (LLM) to improve the accuracy of drug name mapping across international vocabularies. Methods:...
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Endoscopic Ultrasonography-Guided Gallbladder Drainage as a Treatment Option for Acute Cholecystitis after Metal Stent Placement in Malignant Biliary Strictures

Kozakai F, Kanno Y, Ito K, Koshita S, Ogawa T, Kusunose H, Masu K, Sakai T, Murabayashi T, Yonamine K, Kawakami Y, Fujii Y, Miyamoto K, Noda Y

BACKGROUND/AIMS: It is often difficult to manage acute cholecystitis after metal stent (MS) placement in unresectable malignant biliary strictures. The aim of this study was to evaluate the feasibility of...
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Predictive Value of Localized Stenosis of the Main Pancreatic Duct for Early Detection of Pancreatic Cancer

Kanno Y, Koshita S, Ogawa T, Kusunose H, Masu K, Sakai T, Yonamine K, Kawakami Y, Fujii Y, Miyamoto K, Murabayashi T, Kozakai F, Horaguchi , Noda Y, Oikawa M, Okada T, Ito K

BACKGROUND/AIMS: In this study, we aimed to evaluate the predictive value of localized stenosis of the main pancreatic duct (MPD) for early detection of pancreatic cancer. METHODS: Among 689 patients who...
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Predictive Factors for Inaccurate Diagnosis of Swollen Lymph Nodes in Endoscopic Ultrasound-Guided Fine Needle Aspiration

Fujii Y, Kanno Y, Koshita S, Ogawa T, Kusunose H, Masu K, Sakai T, Yonamine K, Kawakami Y, Murabayashi T, Kozakai F, Noda Y, Okada H, Ito K

BACKGROUND/AIMS: This study aimed to identify the predictive factors for inaccurate endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) diagnosis of swollen lymph nodes without rapid on-site cytopathological evaluation. METHODS: Eighty-three consecutive patients...
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