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Preface : Invited Issue Editor Professor Kyu-Chang Wang and Secondary Neurulation : The Current Central Topic in Spinal Dysraphism

Kim CY, Kim SK

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The Evolution of Journal of Korean Neurosurgical Society from 2017 to 2020 : The Beginning of a Great Development

Chung M, Kim BT

Every researcher wants their research to gain more recognition, and this desire is achieved by publishing their article in a journal with higher impact. It is very important to get...
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Tumor Treating Fields : Additional Mechanisms and Additional Applications

Kumaria A

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A Tale of the Tail : A Comprehensive Understanding of the “Human Tail”

Tojima S

Humans do not have tails; however, a congenital anomaly named “human tail” has been recognized since old times. In contrast with its impactful name, the anomaly itself is not fatal,...
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Gastrulation : Current Concepts and Implications for Spinal Malformations

Thompson DNP

It has been recognised for over a century that the events of gastrulation are fundamental in determining, not only the development of the neuraxis but the organisation of the entire...
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Junctional Neurulation : A Junction between Primary and Secondary Neural Tubes

Kim KH, Lee JY

Recent case reports of junctional neural tube defect (JNTD) which is a peculiar type of spinal anomaly showing the functional disconnection of the primary and secondary neural tubes has risen...
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Perspectives : The Role of Clinicians in Understanding Secondary Neurulation

Wang KC

During the last two decades, there have been remarkable advances in knowledge regarding secondary neurulation. An increased number of cases of occult spinal dysraphism and progress in basic embryology research...
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Caudal Agenesis : Understanding the Base of the Wide Clinical Spectrum

Lee JY, Shim Y, Wang KC

Caudal agenesis refers to the congenital malformation with the essential feature of the agenesis of the sacrococcygeal bone. It is associated with various types of spinal cord anomaly as well...
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Cell Lineage, Self-Renewal, and Epithelial-to-Mesenchymal Transition during Secondary Neurulation

Kawachi T, Tadokoro R, Takahashi Y

Secondary neurulation (SN) is a critical process to form the neural tube in the posterior region of the body including the tail. SN is distinct from the anteriorly occurring primary...
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Overview of Secondary Neurulation

Catala M

Secondary neurulation is a morphological process described since the second half of the 19th century; it accounts for the formation of the caudal spinal cord in mammals including humans. A...
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Embryonal Neuromesodermal Progenitors for Caudal Central Nervous System and Tissue Development

Shaker MR, Lee JH, Sun W

Neuromesodermal progenitors (NMPs) constitute a bipotent cell population that generates a wide variety of trunk cell and tissue types during embryonic development. Derivatives of NMPs include both mesodermal lineage cells...
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Sacrococcygeal Teratoma : A Tumor at the Center of Embryogenesis

Phi JH

Sacrococcygeal teratoma (SCT) is an extragonadal germ cell tumor (GCT) that develops in the fetal and neonatal periods. SCT is a type I GCT in which only teratoma and yolk...
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Extremely Low Serum Alanine Transaminase Level Is Associated with All-Cause Mortality in the Elderly after Intracranial Hemorrhage

Kim DY, Cho KC

Objective : Extremely low alanine transaminase (ALT) levels are associated with all-cause mortality in frail elderly individuals; the clinical significance of ALT as a reliable biomarker is now being considered....
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Learning Curve and Complications Experience of Oblique Lateral Interbody Fusion : A Single-Center 143 Consecutive Cases

Oh BK, Son DW, Lee SH, Lee JS, Sung SK, Lee SW, Song GS

Objective : Oblique lateral interbody fusion (OLIF) is becoming the preferred treatment for degenerative lumbar diseases. As beginners, we performed 143 surgeries over 19 months. In these consecutive cases, we...
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Diffusion-Weighted Magnetic Resonance Imaging in the Diagnosis of Cerebral Venous Thrombosis : A Meta-Analysis

Lv B, Jing F, Tian Cl, Liu Jc, Wang J, Cao Xy, Liu Xf, Yu Sy

Objective : A role of diffusion-weighted imaging (DWI) in the diagnosis of cerebral venous thrombosis (CVT) is not wellunderstood. This study evaluates the effectiveness of DWI in the diagnosis of...
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The Fate of Partially Thrombosed Intracranial Aneurysms Treated with Endovascular Intervention

Lee J, Cho WS, Yoo RE, Yoo DH, Cho YD, Kang HS, Kim JE

Objective : The fate of partially thrombosed intracranial aneurysms (PTIAs) is not well known after endovascular treatment. The authors aimed to analyze the treatment outcomes of PTIAs. Methods : We retrospectively...
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Disorders of Secondary Neurulation : Mainly Focused on Pathoembryogenesis

Yang J, Lee JY, Kim KH, Wang KC

Recent advancements in basic research on the process of secondary neurulation and increased clinical experience with caudal spinal anomalies with associated abnormalities in the surrounding and distal structures shed light...
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The Fate of Proximal Junctional Vertebral Fractures after Long-Segment Spinal Fixation : Are There Predictable Radiologic Characteristics for Revision surgery?

Jang HJ, Park JY, Kuh SU, Chin DK, Kim KS, Cho YE, Hahn BS, Kim KH

Objective : To investigate the radiographic characteristics of the uppermost instrumented vertebrae (UIV) and UIV+1 compression fractures that are predictive of revision surgery following long-segment spinal fixation. Methods : A total...
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