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Heat Shock Protein 90 (HSP90) and Immune Regulation

Kim BK, Woo SY

Heat shock protein 90 (HSP90) is involved in conformational and structural maturation of signalling molecules and transcription factors in immune reaction. HSP90 inhibitors induce immune modulation via anti-inflammatory effect, regulating...
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Development and Verification of Nested PCR Assay for Detection of Tobacco rattle virus in Plant Quarantine

Lee S, Lee JY, Shin YG, Lee SH, Ahn TY

Tobacco rattle virus (TRV) is a plant pathogen belonging to the Group IV positive-sense single-stranded RNA viruses. TRV causes disease in various plants (e.g., potato, tomato and tobacco), for which...
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ISAba15 Inserted into Outer Membrane Protein Gene carO in Acinetobacter baumannii

Kim DH, Ko KS

We identified ISAba15 inserted into the carO gene in an Acinetobacter baumannii isolate. The insert disrupted the lpxD gene, resulting in colistin resistance in A. baumannii. Persistence in carbapenem resistance...
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Intranasal Administration Model for Evaluating Protection Against Influenza Virus in Mice

Choi SW, Youn HN, Hong W, Park JK, Yuk SS, Kwon JH, Noh JY, Kang JS, Cho KJ, Ryu JJ, Lee JB, Park SY, Choi IS, Lee SW, Song CS

Antiviral activity against Influenza virus of 14 Lactobacillus species isolated from food was monitored. Lactobacillus species were isolated from traditional Korean fermented food. Each live Lactobacillus was administered into the...
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Prediction of Nuclear Targeting Proteins with Nuclear Localization Signals in Staphylococcus aureus and Nuclear Targeting of beta-lactamase in Host Cells

Ahn SH, Lee JH, Lee JC

Nuclear targeting of bacterial proteins in host cells and subsequent interaction with nuclear molecules are an emerging pathogenic mechanism of bacteria. In this study, we predicted the nuclear targeting proteins...
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Cyclic AMP and Cyclic AMP-Receptor Protein are Required for Optimal Capsular Polysaccharide Expression

Cho HK, Shin SH

Vibrio vulnificus causes fatal infections in susceptible individuals. Group 1 capsular polysaccharide (CPS) operon is responsible for CPS expression, which plays an essential role in the pathogenesis of this pathogen....
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Prevalence and Characterization of Actinobacillus pleuropneumoniae Isolated from Korean Pigs

Lee KE, Choi HW, Kim HH, Song JY, Yang DK

Actinobacillus pleuropneumoniae causes porcine pleuropneumoniae which is one of severe threats to the swine industry. In total, 54 strains of Actinobacillus pleuropneumoniae were isolated from 443 pigs between 2012 and...
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Human Cytomegalovirus Infection in Solid-Organ Transplantation

Kim YH

Human cytomegalovirus (CMV) continues to be a major threat against solid-organ transplant recipients despite significant advancements in its prophylaxis and therapy. Primary CMV infection or reactivation of latent CMV in...
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Roles of Outer Membrane Vesicles (OMVs) in Bacterial Virulence

Lim S, Yoon H

Outer membrane vesicles (OMVs) are ubiquitous membranous structures in all Gram-negative bacteria, including pathogens and non-pathogens. Gram-positive bacteria also release membrane-derived vesicles (MV). Originating from the cell envelope, OMVs are...
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