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Resistance to Chemotherapy on Tumor Through Cathepsin B-dependent Activation of the NLRP3 Inflammasome

Kwon EJ, Koh YS

Anticancer drugs kill tumor cells and increase host anti-tumor immunity. Interestingly, gemcitabin (Gem) and 5-fluorouracil (5-FU), widely used anticancer drugs, lead to IL-1beta secretion releasing cathepsin B which activates Nlrp3...
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Novel Role of Invariant Natural Killer T-cell in Glycemic Control: Regulation by human Adenovirus 36

Park S, Nam JH

Obesity is associated with a state of chronic low-grade inflammation. This abnormal inflammation state may cause metabolic dysfunction. Many studies have supported the claim that immune cells such as adipose...
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A Survey on Laboratory Biosafety Status of Public Healthcare Centers in Korea

Lee KM, Nam HY, Shin SH, Choi MK, Choi YJ, Kwon SH, Park KH, Jang WJ

The purpose of this study was to explore the laboratory biosafety status of Public Health Centers (PHCs) in Korea during Oct.7~26, 2012. We surveyed the environment of biosafety management, especially...
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Cardiac-specific Coxsackievirus and Adenovirus Receptor (CAR) Deletion Inhibit Enterovirus Infection in Murine Heart

Kim JH, Seok H, Lim BK

The structure of coxsackievirus and adenovirus receptor's CAR is similar to adhesion molecules. In the adult heart, the majority of CAR localizes at the intercalated disc. Germ line CAR deletion...
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Serologic Survey of Rabies Virus, Canine Distemper Virus and Parvovirus in Wild Raccoon Dogs (Nyctereutes procyonoides koreensis) in Korea

Yang DK, Kim HH, Nah JJ, Choi SS, Kim JT, Jeong WH, Song JY

Oral rabies vaccination (ORV) program for the wild animals in rabies risk regions of Korea has been conducted since 2000. Evaluation of ORV program under field condition and information concerning...
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Variation and Characterization of Bacterial Communities Contaminating Two Saunas Operated at 64degrees C and 76degrees C

Kim BS, Seo JR, Park DH

This study was performed to analyze 6 day-term variations in bacterial communities contaminating the floor of two dry saunas that were operated at 64degrees C (low temp) and 76degrees C...
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A Virulent Salmonella enterica Serovar Enteritidis Phage SE2 with a Strong Bacteriolytic Activity of Planktonic and Biofilmed Cells

Tiwari BR, Kim S, Kim J

Salmonella enterica serovar Enteritidis is one of the major food borne pathogens. Utilizing lytic bacteriophages against this pathogen can be a new and effective approach for the prevention of food-contamination...
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Development and Application of Cell-penetrating Peptides

Yi H

Intracellular transduction of hydrophilic macromolecules has been problematic owing to the biochemical restriction imposed by lipid bilayer of the cytoplasmic membrane. Several technologies have been developed to improve the intracellular...
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Multiple High-affinity Iron-uptake Systems of Vibrio vulnificus

Shin SH

Vibrio vulnificus is a Gram-negative halophilic bacterium that causes necrotizing wound infections and fatal septicemia, which mainly occur in patients with elevated serum or tissue iron levels. Accumulated experimental data...
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Peptidylarginine Deiminase and Citrullination: Potential Therapeutic Targets for Inflammatory Diseases

Jang B, Shin SJ

The multiple post-translational modifications of proteins display specific gain- or loss-of-function under normal and abnormal conditions. These modifications are precisely regulated by post-translational modification enzymes. The altered molecular status perturbs...
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