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Molecular Characterization of Norovirus and Rotavirus in Outbreak of Acute Gastroenteritis in Seoul

Oh SA, Park SH, Ham HJ, Seung HJ, Jang JI, Suh SW, Jo SJ, Choi SM, Jeong HS

Norovirus and rotavirus are important causes of acute nonbacterial gastroenteritis in communities worldwide. Genotypes of norovirus and rotavirus in stool samples, which were collected from patients, was determined by RT-PCR...
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Herpesvirus-encoded Deubiquitinating Proteases and Their Roles in Regulating Immune Signaling Pathways

Kwon KM, Ahn JH

Viruses interact with the host ubiquitination system in a variety of ways. Viral proteins are often a substrate for ubiquitination, which leads to proteasomal degradation. Viruses also have functions to...
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Strategy for Developing Medical Arsenals by Modulation of Membrane Fusion Activity of Influenza Virus Hemagglutinin

Lee S, Kim JI, Lee I, Park MS

Influenza virus is a serious pathogen that burdens society with health care costs, and can lead to fatality. The virus is dealt with currently by vaccination and anti-influenza drugs. However,...
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Cytoplasmic Translocation of p53 by Human Cytomegalovirus Infection

Kwon Y, Kim J, Kim JH, Hwang ES

p53 is a well-known multi-functional transcription regulator and is critical in the induction of apoptosis in response to various stresses. Human cytomegalovirus (HCMV) infection induced the accumulation of p53, which...
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A Metaviromic Analysis of Viral Communities in the Feces of Unexplained Acute Gastroenteritis

Baek IH, Kim SA, Kim JH, Park HK, Kim W

Although viruses are the most common cause of acute gastroenteritis (AGE) in humans, details about the causative viruses in AGE are largely unknown because many causative viruses are unable to...
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Codon Usage Bias of Human Cytomegalovirus Genes with Different Evolutionary Conservancy

Kim YY, Lee CH

Human cytomegalovirus (HCMV) is a member of beta-herpesvirus and contains a double-stranded genome with longer than 230 Kbp. HCMV infection of human is mostly asymptomatic, but often causes fatal diseases...
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Analysis of Oropharyngeal Microbiota between the Patients with Bronchial Asthma and the Non-Asthmatic Persons

Dang HT, Kim SA, Park HK, Shin JW, Park SG, Kim W

Bronchial asthma can be triggered by microbial agents in the oropharynx. This study was designed to identify the differences in microbiota of oropharynx of bronchial asthmatic patients in contrast to...
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Severe Fever with Thrombocytopenia Syndrome Virus, Crimean-Congo Haemorrhagic Fever Virus, and Migratory Birds

Lee KH, Medlock JM, Heo ST

Severe Fever with Thrombocytopenia Syndrome (SFTS) and Crimean-Congo Haemorrhagic Fever (CCHF) are tick-borne diseases belonging to the family Bunyaviridae. Since SFTS was first reported in China in 2009, the virus...
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Evaluation Methods for the Immunogenicity of Varicella and Zoster Vaccines

Park H

Varicella vaccine has been included in the national immunization program for children since 2005 and zoster vaccine has been released since 2012 in Korea. Even though both varicella and zoster...
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Analysis of the Expression Pattern of microRNA of KSHV in KSHV-infected Human Cells

Kim S, Jang J, Lee MS, Yoo SM

Kaposi's sarcoma associated herpesvirus (KSHV) is subdivided into gamma-herpesvirus and causes Kaposi's sarcoma in human immunodeficiency virus (HIV)-infected patients. A defining feature of herpesviral biology is the presence of two...
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Destructive Intestinal Translocation of Vibrio vulnificus Determines Successful Oral Infection

Hong SH, Jeong K, Park MJ, Lee YS, Nu TM, Kim SY, Rhee JH, Lee SE

Vibrio vulnificus causes primary septicemia as a result of the consumption of contaminated seafood. The intestinal epithelial layer is the first host barrier encountered by V. vulnificus upon oral intake;...
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Comparison of Gene Expression Patterns between Helicobacter pylor 26695 and its Superoxide Dismutase Isogenic Mutant

Cho MJ, Lee SG, Lee KH, Song JY, Lee WK, Baik SC, Rhee KH, Youn HS, Seo JH, Kang HL

Helicobacter pylori, a causative agent of gastroduodenal diseases, is a Gram-negative microaerophilic bacterium. Although H. pylori locates in the microaerophilic mucous layer, the bacteria would come into contact harmful reactive...
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