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Nucleic Acid Recognition and Signaling by Toll-like Receptor 9: Compartment-dependent Regulation

Koh YS

Toll-like receptor 9 binds to DNA from bacteria or viruses and activates a signaling pathway that leads to the induction of proinflammatory cytokines and type I interferon. Adaptor complex AP-3...
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Infectobesity: a New Area for Microbiological and Virological Research

Na HN, Nam JH

Obesity is connected with numerous diseases, such as type 2 diabetes, atherosclerosis, cancer, and nervous system dysfunctions. Obesity is affected by genetic, environmental, and cultural factors. However, numerous studies indicate...
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A Sequence in Coat Protein Open Reading Frame Is Required for Turnip Yellow Mosaic Virus Replication

Shin HI, Cho TJ

Turnip yellow mosaic virus (TYMV) is a spherical plant virus that has a single 6.3 kb positive strand RNA genome. Information for TYMV replication is limited, except that the 3'-terminal...
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Development of a Gene Therapy Method for Cervical Cancer Using Attenuated Coxsackievirus B3 as a Vector System

Shim SH, Kim YJ, Kim DS, Nam JH

We previously reported the development of an attenuated coxsackievirus B3, known as YYFF, which functioned as a viral vector system for foreign gene expression. In this study, we demonstrated the...
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Vibrio vulnificus Hemolysin Is Easily Inactivated in Spite of Being Produced at High Levels in Cirrhotic Ascites by a fur Mutation

Kim CM, Kim SC, Shin SH

Vibrio vulnificus produces Hemolysin/cytolysin (VvhA), which is one of the most potent exotoxins capable of killing mice at submicrogram levels. However, V. vulnificus growth and vvhA expression are severely repressed...
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Investigation of Murine Norovirus Replication in RAW264.7 Cells by Strand-specific RT-PCR

Ji GY, Jang SY, Paik SY, Ko GP, Jeong WH, Lee CH

Murine norovirus (MNV) is a non-enveloped virus with a positive-sense RNA genome and causes lethal infection in mice. MNV has been used as a model virus for human norovirus (NV)...
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Adhesion Activity of Lactobacillus plantarum PM 008 Isolated from Kimchi on the Intestine of Mice

Jang SE, Hyun YJ, Oh YJ, Choi KB, Kim T, Yeo IH, Han MJ, Kim DH

Lactic acid bacteria (LAB), including L. plantarum isolated from Kimchi, are beneficial and safe microorganisms that improve disturbances of the indigenous microflora and the host's immune system. The adhesion abilities...
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HMG CoA Reductase Inhibitors Inhibit HCV RNA Replication of HCV Genotype 1b but Not 2a

Chang KS, Jo HJ

Replication of hepatitis C virus (HCV) is regulated by statin, one of 3-hydroxy-3-methylglutaryl CoA reducatase (HMG CoA reductase) inhibitors that block mevalonate pathway and cholesterol biosyntheis, which has been used...
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The Present and Future of Molecular Epidemiology in Tuberculosis

Park YK

Molecular epidemiology has been initiated for the confirmation of transmission link among tuberculosis patients. IS6110 restriction fragment length polymorphisms (RFLP) technique has been used as an excellent tool to discriminate...
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