J Bacteriol Virol.  2011 Jun;41(2):83-90. 10.4167/jbv.2011.41.2.83.

Adhesion Activity of Lactobacillus plantarum PM 008 Isolated from Kimchi on the Intestine of Mice

Affiliations
  • 1Department of Food and Nutrition, Kyung Hee University, Seoul, Korea. mjhan@khu.ac.kr
  • 2Department of Life and Pharmaceutical Sciences, Kyung Hee University, Seoul, Korea. dhkim@khu.ac.kr
  • 3Pulmuone Co., Seoul, Korea.

Abstract

Lactic acid bacteria (LAB), including L. plantarum isolated from Kimchi, are beneficial and safe microorganisms that improve disturbances of the indigenous microflora and the host's immune system. The adhesion abilities of Kimchi-derived L. plantarum PM008 and yogurt-derived L. casei were measured in vitro and in vivo. When L. plantarum or L. casei was incubated with Caco-2 cells, these Lactobacillus strains were potently attached. When these strains were orally administered to mice, the LABs were attached on the large intestine of mice. The attachment of L. plantarum on murine intestine or Caco-2 intestinal epithelial cell lines was more potent than that of L. casei, although numbers of LAB between their feces were not different. Treatment with either L. plantarum or L. casei for 14 days suppressed fecal beta-glucuronidase activity, although treatment for one day did not affect it. L. plantarum showed more potent inhibition than L. casei. In addition, L. plantarum and L. casei were stable to artificial gastric and intestinal juice. L. plantarum was more stable than L. casei. Based on these findings, the survival and adhesion effects of orally administered LAB strains in the intestine may increase numbers of LAB in intestine and express their biological activities.

Keyword

Lactic acid bacteria; Lactobacillus plantarum; Lactobacillus casei; Adhesion activity

MeSH Terms

Animals
Bacteria
Caco-2 Cells
Epithelial Cells
Feces
Glucuronidase
Humans
Immune System
Intestine, Large
Intestines
Lactic Acid
Lactobacillus
Lactobacillus casei
Lactobacillus plantarum
Mice
Pyridines
Thiazoles
Glucuronidase
Lactic Acid
Pyridines
Thiazoles
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