- A Benzylideneacetophenone Derivative Induces Apoptosis of Radiation-Resistant Human Breast Cancer Cells via Oxidative Stress
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Park JE, Piao MJ, Kang KA, Shilnikova K, Hyun YJ, Oh SK, Jeong YJ, Chae S, Hyun JW
- KMID: 2386907
- Biomol Ther.
- 2017 Jul;25(4):404-410.
- doi: 10.4062/biomolther.2017.010
Benzylideneacetophenone derivative (1E)-1-(4-hydroxy-3-methoxyphenyl) hept-1-en-3-one (JC3) elicited cytotoxic effects on MDA-MB 231 human breast cancer cells-radiation resistant cells (MDA-MB 231-RR), in a dose-dependent manner, with an IC₅₀ value of 6 μM... -
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- Shikonin Exerts Cytotoxic Effects in Human Colon Cancers by Inducing Apoptotic Cell Death via the Endoplasmic Reticulum and Mitochondria-Mediated Pathways
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Han X, Kang KA, Piao MJ, Zhen AX, Hyun YJ, Kim HM, Ryu YS, Hyun JW
- KMID: 2432065
- Biomol Ther.
- 2019 Jan;27(1):41-47.
- doi: 10.4062/biomolther.2018.047
The apoptotic effects of shikonin (5,8-dihydroxy-2-[(1R)-1-hydroxy-4-methylpent-3-enyl]naphthalene-1,4-dione) on the human colon cancer cell line SNU-407 were investigated in this study. Shikonin showed dose-dependent cytotoxic activity against SNU-407 cells, with an estimated... -
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- 7,8-Dihydroxyflavone Protects High Glucose-Damaged Neuronal Cells against Oxidative Stress
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Cho SJ, Kang KA, Piao MJ, Ryu YS, Fernando P, Zhen AX, Hyun YJ, Ahn MJ, Kang HK, Hyun JW
- KMID: 2432071
- Biomol Ther.
- 2019 Jan;27(1):85-91.
- doi: 10.4062/biomolther.2018.202
Oxidative stress is considered a major contributor in the pathogenesis of diabetic neuropathy and in diabetes complications, such as nephropathy and cardiovascular diseases. Diabetic neuropathy, which is the most frequent... -
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- Purpurogallin Protects Keratinocytes from Damage and Apoptosis Induced by Ultraviolet B Radiation and Particulate Matter 2.5
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Zhen AX, Piao MJ, Hyun YJ, Kang KA, Ryu YS, Cho SJ, Kang HK, Koh YS, Ahn MJ, Kim TH, Hyun JW
- KMID: 2455095
- Biomol Ther.
- 2019 Jul;27(4):395-403.
- doi: 10.4062/biomolther.2018.151
Purpurogallin, a natural phenol obtained from oak nutgalls, has been shown to possess antioxidant, anticancer, and anti-inflammatory effects. Recently, in addition to ultraviolet B (UVB) radiation that induces cell apoptosis... -
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- Adhesion Activity of Lactobacillus plantarum PM 008 Isolated from Kimchi on the Intestine of Mice
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Jang SE, Hyun YJ, Oh YJ, Choi KB, Kim T, Yeo IH, Han MJ, Kim DH
- KMID: 2168625
- J Bacteriol Virol.
- 2011 Jun;41(2):83-90.
- doi: 10.4167/jbv.2011.41.2.83
Lactic acid bacteria (LAB), including L. plantarum isolated from Kimchi, are beneficial and safe microorganisms that improve disturbances of the indigenous microflora and the host's immune system. The adhesion abilities... -
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- Large Deletion in KCNQ1 Identified in a Family with Jervell and Lange-Nielsen Syndrome
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Sung JY, Bae EJ, Park S, Kim SY, Hyun YJ, Park SS, Seong MW
- KMID: 1791957
- Ann Lab Med.
- 2014 Sep;34(5):395-398.
- doi: 10.3343/alm.2014.34.5.395
Long QT syndrome (LQTS) is a genetically heterogeneous disorder associated with sequence variations in more than 10 genes; in some cases, it is caused by large deletions or duplications among... -
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- Oncogenic osteomalacia caused by a phosphaturic mesenchymal tumor of the oral cavity: a case report
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Yang IM, Park YK, Hyun YJ, Kim DY, Woo JT, Kim SW, Kim JW, Kim YS, Choi YK
- KMID: 1038862
- Korean J Intern Med.
- 1997 Jan;12(1):89-95.
We report a case of oncogenic osteomalacia associated with a phosphaturic mesenchymal tumor in a 31-year-old woman. She was presented with severe generalized bone and muscle pain and was restricted... -
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- Clinical and psychological characteristics of propofol abusers in Korea: a survey of propofol abuse in 38, non-healthcare professionals
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Kim EJ, Kim SH, Hyun YJ, Noh YK, Jung HS, Han SY, Park CH, Choi BM, Noh GJ
- KMID: 2237310
- Korean J Anesthesiol.
- 2015 Dec;68(6):586-593.
- doi: 10.4097/kjae.2015.68.6.586
BACKGROUND: The aim of this study is to investigate the characteristics of propofol abuse based on the results of a survey analysis of abusers among non-healthcare professionals in Korea. METHODS: Thirty-eight... -
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- Effects of CYP2C19 Genetic Polymorphisms on PK/PD Responses of Omeprazole in Korean Healthy Volunteers
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Park S, Hyun YJ, Kim YR, Lee JH, Ryu S, Kim JM, Oh WY, Na HS, Lee JG, Seo DW, Hwang IY, Park Z, Jang IJ, Oh J, Choi SE
- KMID: 2375071
- J Korean Med Sci.
- 2017 May;32(5):729-736.
- doi: 10.3346/jkms.2017.32.5.729
The aim of this study was to examine the effects of CYP2C19*2 and *3 genetic polymorphisms on omeprazole pharmacokinetic (PK) and pharmacodynamic (PD) responses. Twenty-four healthy Korean volunteers were enrolled... -
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- The Effect of L-Carnitine and Isoflavone Supplementation on Weight Reduction and Visceral Fat Accumulation in Overweight Women
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Gwak JH, Lee JH, Lee SJ, Park HW, Kim Y, Hyun YJ
- KMID: 2260574
- Korean J Nutr.
- 2007 Oct;40(7):630-638.
This study was performed to examine the combined effects of L-carnitine and isoflavone supplementation on weight reduction and body fat distribution in overweight women. Overweight/obese women (body mass index >... -
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- The Effect of Red-Yeast-Rice Supplement on Serum Lipid Profile and Glucose Control in Subjects with Impaired Fasting Glucose or Impaired Glucose Tolerance
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Kang MR, Kim JY, Hyun YJ, Kim HJ, Yeo HY, Song YD, Lee JH
- KMID: 2261193
- Korean J Nutr.
- 2008 Jan;41(1):31-40.
This study was aimed at evaluating the effect of red-yeast-rice supplementation on cholesterol-lowering and glucose control in subjects with impaired fasting glucose (IFT) or impaired glucose tolerance (IGT). We conducted... -
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