- Effect of Mild Hypothermia on the Mitogen Activated Protein Kinases in Experimental Stroke
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Han HS
- KMID: 1611345
- Korean J Physiol Pharmacol.
- 2004 Aug;8(4):187-194.
Middle cerebral artery occlusion (MCAO) results in cell death by activation of complex signal pathways for cell death and survival. Hypothermia is a robust neuroprotectant, and its effect has often... -
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- Mitogen-activated Protein Kinases in the Development of Normal and Diseased Kidneys
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Awazu M
- KMID: 2377561
- Child Kidney Dis.
- 2017 Apr;21(1):1-7.
- doi: 10.3339/jkspn.2017.21.1.1
Mitogen-activated protein kinases (MAPKs) play important roles in various cellular functions including proliferation, differentiation, and apoptosis. We showed that MAPKs are developmentally regulated in the rat kidney. p38 MAPK (p38)... -
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- Bacterial Endotoxin, Lipopolysaccaride, and Induced Activation of Stress-Activated Protein Kinase and Generation of Nitric Oxide
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Choi SJ, Lee YS, Park RK, Chung SY, Kim SK
- KMID: 2206461
- J Korean Surg Soc.
- 1999 Apr;56(4):468-478.
BACKGROUND: Previously, it has been suggested that lipopolysaccaride (LPS) stimulates the activation of the transcriptional factor activator protein (AP-1) which is in part regulated by activation of the c-Jun N-terminal... -
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- Immunohistochemical Study on MAPK Expression in Seborrheic Keratosis and Squamous Cell Carcinoma by Sun Exposure
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Cho KM, Lee SY, Park YL, Lee JS, Whang KU
- KMID: 2302609
- Korean J Dermatol.
- 2005 Jun;43(6):749-755.
BACKGROUND: Mitogen-activated protein kinase (MAPK) is a key molecule in intracellular signal transducing pathways that transport extracellular stimuli from cell surface to nuclei. The MAPK family, comprised of extracellular signal-regulated... -
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- Involvement of ERK1/2 and JNK Pathways in 17beta-estradiol Induced Kir6.2 and SK2 Upregulation in Rat Osteoblast-like Cells
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Kim JW, Yang EK
- KMID: 1587398
- Korean J Physiol Pharmacol.
- 2006 Aug;10(4):199-205.
The functional expression of potassium (K+) channels has electrophysiologically been studied in bone cells from several species, however, their identity and regulation of gene expressions in bone cells are not... -
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- Activation of Mitogen-Activated Protein Kinases in the Rat Dorsal Root Ganglia Following Peripheral Tissue Inflammation or Nerve Injuries
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Bae JC, Lee HL, Lee KM, Hwang SH, Sohn SJ, Kim DS, Cho HJ
- KMID: 1514946
- Korean J Anat.
- 2003 Jun;36(3):237-246.
The mitogen-activated protein kinase (MAPK) family has three members: the extracellular signal-regulated kinase (ERK), p38 MAPK and c-Jun N-terminal kinase (JNK). There is substantial evidence indicating that the MAPK cascade... -
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- Effects of Mycoplasma Pneumoniae on Activation of Human Eosinophilic Leukaemia EoL-1 Cells
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Kim ES, Lee KE, Yang HS, Kim KW, Park JY, Sohn MH, Kim KE
- KMID: 2314450
- Pediatr Allergy Respir Dis.
- 2007 Mar;17(1):8-16.
PURPOSE: Mycoplasma pneumoniae is a common cause of lower respiratory disease, especially in children and young adults. Several studies have suggested that respiratory infection by M. pneumoniae is associated with... -
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- Dexamethasone Inhibits Interleukin-1beta-Induced Matrix Metalloproteinase-9 Expression in Cochlear Cells
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Nam SI, Kwon TK
- KMID: 1973466
- Clin Exp Otorhinolaryngol.
- 2014 Sep;7(3):175-180.
- doi: 10.3342/ceo.2014.7.3.175
OBJECTIVES: To investigate the effect of interleukin (IL)-1beta on matrix metalloproteinase (MMP)-9 expression in cochlea and regulation of IL-1beta-mediated MMP-9 expression by dexamethasone and the molecular and signaling mechanisms involved. METHODS:... -
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- Activation of Mitogen-activated Protein Kinases in Hypoxia-induced Apoptosis of PC12 Cell
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Kim BC, Kim MK, Cho KH, Kim YS, Lee KY
- KMID: 2342903
- J Korean Neurol Assoc.
- 2001 Jul;19(4):384-392.
BACKGROUND: The Mitogen-activated Protein Kinase (MAPK) family is comprised of key regulatory proteins that control the cellular response to both proliferation and stress signals. Cell death is usually mediated through... -
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- Stimulus-dependent Differential Regulation of JNK1 and JNK3 by JIP1 Scaffold Protein in Human Neuroblastoma, SH-SY5Y
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Yu YM, Lee KW, Lee JK
- KMID: 2224481
- Korean J Anat.
- 2006 Feb;39(1):47-53.
Activation of c-Jun N-terminal kinase (JNK) is associated with a wide range of disparate cellular responses to extracellular stimuli. In mammals, three JNK isoforms are known, and their differential regulation... -
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- Involvement of JNK-initiated p53 accumulation and phosphorylation of p53 in pseudolaric acid B induced cell death
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Gong X, Wang M, Tashiro SI, Onodera S, Ikejima T
- KMID: 1110127
- Exp Mol Med.
- 2006 Aug;38(4):428-434.
A terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay was used to determine that apoptosis causes HeLa cell death induced by pseudolaric acid B. The c-Jun N-terminal kinase (JNK) inhibitor... -
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- Mechanism of Macrophage-Derived Chemokine/CCL22 Production by HaCaT Keratinocytes
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Yano C, Saeki H, Komine M, Kagami S, Tsunemi Y, Ohtsuki M, Nakagawa H
- KMID: 2264803
- Ann Dermatol.
- 2015 Apr;27(2):152-156.
- doi: 10.5021/ad.2015.27.2.152
BACKGROUND: CC chemokine ligand 17 (CCL17) and CCL22 are the functional ligands for CCR4. We previously reported that inhibitors of nuclear factor-kappa B and p38 mitogen-activated protein kinase (p38 MAPK),... -
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- Long-term Activation of c-Jun N-terminal Kinase through Receptor Interacting Protein is Associated with DNA Damage-induced Cell Death
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Seok JH, Park KA, Byun HS, Won M, Shin S, Choi BL, Lee H, Kim YR, Hong JH, Park J, Hur GM
- KMID: 1838357
- Korean J Physiol Pharmacol.
- 2008 Aug;12(4):185-191.
- doi: 10.4196/kjpp.2008.12.4.185
Activation of c-Jun N-terminal kinase (JNK), a member of the mitogen-activated protein kinase family, is an important cellular response that modulates the outcome of the cells which are exposed to... -
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- A New Neolignan Derivative, Balanophonin Isolated from Firmiana simplex Delays the Progress of Neuronal Cell Death by Inhibiting Microglial Activation
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Lim SY, Subedi L, Shin D, Kim CS, Lee KR, Kim SY
- KMID: 2389384
- Biomol Ther.
- 2017 Sep;25(5):519-527.
- doi: 10.4062/biomolther.2016.224
Excessive activation of microglia causes the continuous production of neurotoxic mediators, which further causes neuron degeneration. Therefore, inhibition of microglial activation is a possible target for the treatment of neurodegenerative... -
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- Protective Effect of Sauchinone Against Regional Myocardial Ischemia/Reperfusion Injury: Inhibition of p38 MAPK and JNK Death Signaling Pathways
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Kim SJ, Jeong CW, Bae HB, Kwak SH, Son JK, Seo CS, Lee HJ, Lee J, Yoo KY
- KMID: 1372805
- J Korean Med Sci.
- 2012 May;27(5):572-575.
- doi: 10.3346/jkms.2012.27.5.572
Sauchinone has been known to have anti-inflammatory and antioxidant effects. We determined whether sauchinone is beneficial in regional myocardial ischemia/reperfusion (I/R) injury. Rats were subjected to 20 min occlusion of... -
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- Ceramides and Cell Signaling Molecules in Psoriatic Epidermis: Reduced Levels of Ceramides, PKC-alpha, and JNK
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Lew BL, Cho Y, Kim J, Sim WY, Kim NI
- KMID: 2157790
- J Korean Med Sci.
- 2006 Feb;21(1):95-99.
- doi: 10.3346/jkms.2006.21.1.95
Ceramides are the main lipids in the stratum corneum and are generated during cellular stress and apoptosis by de novo synthesis or by the action of sphingomyelinase. In addition, they... -
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- Constitutive Expression of MAP Kinase Phosphatase-1 Confers Multi-drug Resistance in Human Glioblastoma Cells
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Yu H, Park J, Lee J, Choi K, Choi C
- KMID: 1972728
- Cancer Res Treat.
- 2012 Sep;44(3):195-201.
PURPOSE: Current treatment of glioblastoma after surgery consists of a combination of fractionated radiotherapy and temozolomide. However, it is difficult to completely remove glioblastoma because it has uncertain boundaries with... -
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- Angiotensin III increases monocyte chemoattractant protein-1 expression in cultured human proximal tubular epithelial cells
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Kim HW, Kim YO, Yoon SA, Han JS, Chun HB, Kim YS
- KMID: 2373780
- Korean J Intern Med.
- 2016 Jan;31(1):116-124.
- doi: 10.3904/kjim.2016.31.1.116
BACKGROUND/AIMS: We investigated whether angiotensin III (Ang III) is involved in monocyte recruitment through regulation of the chemokine monocyte chemoattractant protein-1 (MCP-1) in cultured human proximal tubular epithelial cells (HK-2... -
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- Anti-Proliferative Effects of Rutin on OLETF Rat Vascular Smooth Muscle Cells Stimulated by Glucose Variability
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Yu SH, Yu JM, Yoo HJ, Lee SJ, Kang DH, Cho YJ, Kim DM
- KMID: 2374042
- Yonsei Med J.
- 2016 Mar;57(2):373-381.
- doi: 10.3349/ymj.2016.57.2.373
PURPOSE: Proliferation of vascular smooth muscle cells (VSMCs) plays a crucial role in atherosclerosis. Rutin is a major representative of the flavonol subclass of flavonoids and has various pharmacological activities.... -
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- Wnt5a stimulates chemotactic migration and chemokine production in human neutrophils
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Jung YS, Lee HY, Kim SD, Park JS, Kim JK, Suh PG, Bae YS
- KMID: 2154246
- Exp Mol Med.
- 2013 Jun;45(6):e27.
Wnt5a is a ligand that activates the noncanonical Wnt signaling pathways (beta-catenin-independent pathways). Human neutrophils expressed several Wnt5a receptors, such as Frizzled 2, 5 and 8. Stimulation of human neutrophils... -
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