- Baicalein Treatment Promotes Osteoblast Proliferation and Osteogenic Differentiation through Activation of Immediate Early Response 3
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Lee SI
- KMID: 2469741
- J Dent Hyg Sci.
- 2019 Dec;19(4):254-260.
- doi: 10.17135/jdhs.2019.19.4.254
BACKGROUND: The primary aims of periodontal disease treatment is to remove dental plaque and calculus, the main causes of tooth loss, and restore periodontal tissue destroyed by inflammation. Periodontal disease... -
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- Cyclosporin A aggravates hydrogen peroxide-induced cell death in kidney proximal tubule epithelial cells
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Moon D, Kim J
- KMID: 2459547
- Anat Cell Biol.
- 2019 Sep;52(3):312-323.
- doi: 10.5115/acb.18.192
Cyclosporin A (CsA) does not only exert a toxic effect on kidney parenchymal cells, but also protects them against necrotic cell death by inhibiting opening of mitochondrial permeability transition pore.... -
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- 7,8,4′-Trihydroxyisoflavone, a Metabolized Product of Daidzein, Attenuates 6-Hydroxydopamine-Induced Neurotoxicity in SH-SY5Y Cells
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Ko YH, Kim SK, Kwon SH, Seo JY, Lee BR, Kim YJ, Hur KH, Kim SY, Lee SY, Jang CG
- KMID: 2455091
- Biomol Ther.
- 2019 Jul;27(4):363-372.
- doi: 10.4062/biomolther.2018.211
Daidzein isolated from soybean (Glycine max) has been widely studied for its antioxidant and anti-inflammatory activities. However, the protective effects of 7,8,4′-trihydroxyisoflavone (THIF), a major metabolite of daidzein, on 6-hydroxydopamine... -
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- Mannosylerythritol lipids ameliorate ultraviolet A-induced aquaporin-3 downregulation by suppressing c-Jun N-terminal kinase phosphorylation in cultured human keratinocytes
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Bae IH, Lee SH, Oh S, Choi H, Marinho PA, Yoo JW, Ko JY, Lee ES, Lee TR, Lee CS, Kim DY
- KMID: 2438085
- Korean J Physiol Pharmacol.
- 2019 Mar;23(2):113-120.
- doi: 10.4196/kjpp.2019.23.2.113
Mannosylerythritol lipids (MELs) are glycolipids and have several pharmacological efficacies. MELs also show skin-moisturizing efficacy through a yet-unknown underlying mechanism. Aquaporin-3 (AQP3) is a membrane protein that contributes to the... -
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- N-acetyl-l-cysteine controls osteoclastogenesis through regulating Th17 differentiation and RANKL in rheumatoid arthritis
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Kim HR, Kim KW, Kim BM, Lee KA, Lee SH
- KMID: 2452505
- Korean J Intern Med.
- 2019 Jan;34(1):210-219.
- doi: 10.3904/kjim.2016.329
BACKGROUND/AIMS: This study aimed to determine the regulatory role of N-acetyl-l-cysteine (NAC), an antioxidant, in interleukin 17 (IL-17)-induced osteoclast differentiation in rheumatoid arthritis (RA). METHODS: After RA synovial fibroblasts were stimulated... -
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- Beneficial Role of Hydrogen Sulfide in Renal Ischemia Reperfusion Injury in Rats
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Choi EK, Park SH, Lim JA, Hong SW, Kwak KH, Park SS, Lim DG, Jung H
- KMID: 2419730
- Yonsei Med J.
- 2018 Oct;59(8):960-967.
- doi: 10.3349/ymj.2018.59.8.960
PURPOSE: Hydrogen sulfide (H2S) is an endogenous gaseous molecule with important physiological roles. It is synthesized from cysteine by cystathionine γ-lyase (CGL) and cystathionine β-synthase (CBS). The present study examined... -
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- Expression of Fibroblast Growth Factor 21 and β-Klotho Regulates Hepatic Fibrosis through the Nuclear Factor-κB and c-Jun N-Terminal Kinase Pathways
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Lee KJ, Jang YO, Cha SK, Kim MY, Park KS, Eom YW, Baik SK
- KMID: 2417312
- Gut Liver.
- 2018 Jul;12(4):449-456.
- doi: 10.5009/gnl17443
BACKGROUND/AIMS: Fibroblast growth factor (FGF) 21 is associated with hepatic inflammation and fibrosis. However, little is known regarding the effects of inflammation and fibrosis on the β-Klotho and FGF21 pathway... -
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- Compound K Inhibits Interleukin-1β-induced Expression of Inflammatory Mediators and Matrix Metalloproteinases by Inhibiting Mitogen-activated Protein Kinase Activation in Chondrocytes
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Park EH, Kim JS, Lee JS, Lee YJ, Song YW, Lee EY
- KMID: 2415607
- J Rheum Dis.
- 2018 Jul;25(3):188-196.
- doi: 10.4078/jrd.2018.25.3.188
OBJECTIVE: This study examined the anti-inflammatory and chondroprotective effects of compound K (CK), a ginsenoside metabolite, on chondrocytes from osteoarthritis (OA) patients following stimulation with interleukin (IL)-1β. METHODS: Articular cartilage samples... -
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- Atorvastatin inhibits osteoclast differentiation by suppressing NF-κB and MAPK signaling during IL-1β-induced osteoclastogenesis
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Lee WS, Lee EG, Sung MS, Choi YJ, Yoo WH
- KMID: 2411552
- Korean J Intern Med.
- 2018 Mar;33(2):397-406.
- doi: 10.3904/kjim.2015.244
BACKGROUND/AIMS: To define the effect of statins on interleukin 1β (IL-1β)-induced osteoclastogenesis and elucidate the underlying mechanisms. METHODS: Bone marrow cells were obtained from 5-week-old male ICR (Institute for Cancer Research)... -
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- The Effects of Flecainide Acetate on Inflammatory-Immune Response in Lipopolysaccharide-Stimulated Neutrophils and on Mortality in Septic Rats
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Chung SY, Kim J, Bae HB, Tin TD, Ju W, Kwak SH
- KMID: 2436305
- Acute Crit Care.
- 2018 Feb;33(1):34-41.
- doi: 10.4266/acc.2017.00577
BACKGROUND: Flecainide acetate is a drug used primarily for cardiac arrhythmia. Some studies also imply that flecainide acetate has the potential to regulate inflammatory-immune responses; however, its mechanism of action... -
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- Static magnetic fields promote osteoblastic/cementoblastic differentiation in osteoblasts, cementoblasts, and periodontal ligament cells
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Kim EC, Park J, Kwon IK, Lee SW, Park SJ, Ahn SJ
- KMID: 2392716
- J Periodontal Implant Sci.
- 2017 Oct;47(5):273-291.
- doi: 10.5051/jpis.2017.47.5.273
PURPOSE: Although static magnetic fields (SMFs) have been used in dental prostheses and osseointegrated implants, their biological effects on osteoblastic and cementoblastic differentiation in cells involved in periodontal regeneration remain... -
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- Black soybean anthocyanins attenuate inflammatory responses by suppressing reactive oxygen species production and mitogen activated protein kinases signaling in lipopolysaccharide-stimulated macrophages
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Kim JN, Han SN, Ha TJ, Kim HK
- KMID: 2390127
- Nutr Res Pract.
- 2017 Oct;11(5):357-364.
- doi: 10.4162/nrp.2017.11.5.357
BACKGROUND/OBJECTIVES: Oxidative stress is closely related with inflammation and development of many diseases. Black soybean seed coat contains high amount of anthocyanins, which are well-known for free radical scavenging activities.... -
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- Melatonin Rescues Human Dental Pulp Cells from Premature Senescence Induced by Hâ‚‚Oâ‚‚
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Park S, Bak KJ, Ok CY, Park HJ, Jang HO, Bae MK, Bae SK
- KMID: 2394577
- Int J Oral Biol.
- 2017 Sep;42(3):91-97.
- doi: 10.11620/IJOB.2017.42.3.091
Although anti-aging activities of melatonin, a hormone secreted by the pineal gland, have been reported in senescence-accelerated mouse models and several types of cells, its impact and mechanism on the... -
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- A New Neolignan Derivative, Balanophonin Isolated from Firmiana simplex Delays the Progress of Neuronal Cell Death by Inhibiting Microglial Activation
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Lim SY, Subedi L, Shin D, Kim CS, Lee KR, Kim SY
- KMID: 2389384
- Biomol Ther.
- 2017 Sep;25(5):519-527.
- doi: 10.4062/biomolther.2016.224
Excessive activation of microglia causes the continuous production of neurotoxic mediators, which further causes neuron degeneration. Therefore, inhibition of microglial activation is a possible target for the treatment of neurodegenerative... -
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- Substrate roughness induces the development of defective E-cadherin junctions in human gingival keratinocytes
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Jin C, Lee G, Oh C, Kim HJ, Kim HM
- KMID: 2377746
- J Periodontal Implant Sci.
- 2017 Apr;47(2):116-131.
- doi: 10.5051/jpis.2017.47.2.116
PURPOSE: The entry of bacteria or harmful substances through the epithelial seal of human gingival keratinocytes (HGKs) in the junctional epithelium (JE) is blocked by specialized intercellular junctions such as... -
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- Mitogen-activated Protein Kinases in the Development of Normal and Diseased Kidneys
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Awazu M
- KMID: 2377561
- Child Kidney Dis.
- 2017 Apr;21(1):1-7.
- doi: 10.3339/jkspn.2017.21.1.1
Mitogen-activated protein kinases (MAPKs) play important roles in various cellular functions including proliferation, differentiation, and apoptosis. We showed that MAPKs are developmentally regulated in the rat kidney. p38 MAPK (p38)... -
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- A High-fat Diet Induces a Loss of Midbrain Dopaminergic Neuronal Function That Underlies Motor Abnormalities
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Jang Y, Lee MJ, Han J, Kim SJ, Ryu I, Ju X, Ryu MJ, Chung W, Oh E, Kweon GR, Heo JY
- KMID: 2376578
- Exp Neurobiol.
- 2017 Apr;26(2):104-112.
- doi: 10.5607/en.2017.26.2.104
Movement defects in obesity are associated with peripheral muscle defects, arthritis, and dysfunction of motor control by the brain. Although movement functionality is negatively correlated with obesity, the brain regions... -
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- Immunostimulatory Activity of Apios Tuber Extract on RAW264.7 Macrophage Cells
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Cui J, Kim Y, Lee EB, Kim JK, Kang TH, Jang HH
- KMID: 2366870
- J Bacteriol Virol.
- 2016 Dec;46(4):248-257.
- doi: 10.4167/jbv.2016.46.4.248
Apios americana Medik tubers are medicinal foods with anti-cancer and anti-inflammatory activities. However, mechanisms of immunostimulatory action of the Apios tuber extract (ATE) on macrophages have not been elucidated. In... -
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- Aristolochia manshuriensis Kom ethyl acetate extract protects against high-fat diet-induced non-alcoholic steatohepatitis by regulating kinase phosphorylation in mouse
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Kwak DH, Kim JS, Chang KT, Choo YK
- KMID: 2413126
- J Vet Sci.
- 2016 Sep;17(3):279-287.
- doi: 10.4142/jvs.2016.17.3.279
Aristolochia manshuriensis Kom (AMK) is an herb used as a traditional medicine; however, it causes side effects such as nephrotoxicity and carcinogenicity. Nevertheless, AMK can be applied in specific ways... -
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- Aloe-Emodin Induces Chondrogenic Differentiation of ATDC5 Cells via MAP Kinases and BMP-2 Signaling Pathways
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Yang M, Li L, Heo SM, Soh Y
- KMID: 2351688
- Biomol Ther.
- 2016 Jul;24(4):395-401.
- doi: 10.4062/biomolther.2016.020
Endochondral bone formation is the process by which mesenchymal cells condense into chondrocytes, which are ultimately responsible for new bone formation. The processes of chondrogenic differentiation and hypertrophy are critical... -
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